Analysis of hematopoiesis in mice irradiated with 500 mGy of X rays at different stages of development
- U. de Biologia Molecular y Celular, Madrid (Spain)
We have investigated whether a relatively low dose of 500 mGy of X rays given as a single acute irradiation at different stages of pre-and postnatal development induces significant changes in the content of femoral hematopoietic progenitores during a 1-year period after irradiation. Data obtained show that, in the case of 4-day-old embryos as well as in 2-day, 8-day and 12-week-old mice, this dose is below the threshold capable of inducing a long-term impairment of hematopoiesis in the mouse. Nevertheless, in mice irradiated at the 13th or the 17th day postconception, a hematopoietic dysfunction consisting of a significant reduction in the proportion of femoral granulocyte-macrophage colony-forming units (CFU-GM) was manifested 1 year after irradiation. Our study confirms that, for most stages of development in the mouse, a single acute X irradiation of 500 mGy is below the threshold dose capable of inducing deterministic effects in the mouse hematopoietic system, although it reveals the induction of a significant impairment in the CFU-GM population when irradiation is given at the late stages of embryonic development. 24 refs., 4 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 146892
- Journal Information:
- Radiation Research, Vol. 143, Issue 3; Other Information: PBD: Sep 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chronic inflammation impairs hematopoiesis and survival after irradiation
Dose rate effects on the survival of normal hematopoietic stem cells cells of BALB/c mice