Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids
Abstract
Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited the high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. Furthermore, by programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.
- Authors:
-
[1];
[2];
[2];
[2];
[5];
[5];
[6]
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Washington State Univ., Pullman, WA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); State Univ. of New York, Binghamton, NY (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Linyi Univ. Shandong (China)
- Washington State Univ., Pullman, WA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division
- OSTI Identifier:
- 1784559
- Report Number(s):
- PNNL-SA-160450
Journal ID: ISSN 2639-4979
- Grant/Contract Number:
- AC05-76RL01830; AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Materials Letters
- Additional Journal Information:
- Journal Volume: 3; Journal Issue: 4; Journal ID: ISSN 2639-4979
- Publisher:
- ACS Publications
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 2D nanomaterials; Aqueous self-assembly; Photostability; Peptoid-based materials; Dyes and pigments; Fluorescence; Molecules; Two dimensional materials
Citation Formats
Song, Yang, Wang, Mingming, Akkineni, Susrut, Yang, Wenchao, Hettige, Jeevapani J., Jin, Haibao, Liao, Zhihao, Mu, Peng, Yan, Feng, Baer, Marcel, De Yoreo, James J., Du, Dan, Lin, Yuehe, and Chen, Chun-Long. Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids. United States: N. p., 2021.
Web. doi:10.1021/acsmaterialslett.1c00110.
Song, Yang, Wang, Mingming, Akkineni, Susrut, Yang, Wenchao, Hettige, Jeevapani J., Jin, Haibao, Liao, Zhihao, Mu, Peng, Yan, Feng, Baer, Marcel, De Yoreo, James J., Du, Dan, Lin, Yuehe, & Chen, Chun-Long. Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids. United States. https://doi.org/10.1021/acsmaterialslett.1c00110
Song, Yang, Wang, Mingming, Akkineni, Susrut, Yang, Wenchao, Hettige, Jeevapani J., Jin, Haibao, Liao, Zhihao, Mu, Peng, Yan, Feng, Baer, Marcel, De Yoreo, James J., Du, Dan, Lin, Yuehe, and Chen, Chun-Long. Mon .
"Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids". United States. https://doi.org/10.1021/acsmaterialslett.1c00110. https://www.osti.gov/servlets/purl/1784559.
@article{osti_1784559,
title = {Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids},
author = {Song, Yang and Wang, Mingming and Akkineni, Susrut and Yang, Wenchao and Hettige, Jeevapani J. and Jin, Haibao and Liao, Zhihao and Mu, Peng and Yan, Feng and Baer, Marcel and De Yoreo, James J. and Du, Dan and Lin, Yuehe and Chen, Chun-Long},
abstractNote = {Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited the high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. Furthermore, by programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.},
doi = {10.1021/acsmaterialslett.1c00110},
journal = {ACS Materials Letters},
number = 4,
volume = 3,
place = {United States},
year = {Mon Mar 22 00:00:00 EDT 2021},
month = {Mon Mar 22 00:00:00 EDT 2021}
}
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