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Title: Peptoid-based membrane-mimetic two dimensional nanomaterials

Abstract

This paper presents a review of membrane-mimetic two dimensional (2D) nanomaterials assembled from sequence-defined, diblock-like peptoids through an evaporation-induced crystallization method. Similar to those associated with cell membranes, these peptoid-based nanomembranes exhibit thicknesses in the 3.5 - 5.6 nm range, spontaneous assembly at interfaces, thickness variations in response to changes in Na+ concentrations, and the ability to self-repair. Moreover, they are highly stable, free-standing, and atomically ordered. Both experimental and simulations studies showed that these nanomembranes were formed through an anisotropic formation process. We further demonstrated the incorporation and patterning of a broad range of functional groups within peptoid membranes through large side-chain diversity and/or co-crystallization approaches. By tuning the peptoid hydrophobic domains which determine the stability of nanomembranes, we demonstrated the assembly of single-walled crystalline nanotubes through folding peptoid-based 2D nanomaterials. Given peptoids are biocompatible and easy to synthesize, we anticipate this new class of peptoid-based 2D nanomaterials will provide a robust platform for development of biomimetic materials tailored to specific applications.

Authors:
 [1]
  1. BATTELLE (PACIFIC NW LAB)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1481921
Report Number(s):
PNNL-SA-133246
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Conference
Resource Relation:
Conference: Micro- and Nanotechnology Sensors, Systems, and Applications X, April 15-19, 2018,Orlando, Florida. Proceedings of the SPIE
Country of Publication:
United States
Language:
English

Citation Formats

Chen, Chunlong. Peptoid-based membrane-mimetic two dimensional nanomaterials. United States: N. p., 2018. Web. doi:10.1117/12.2303685.
Chen, Chunlong. Peptoid-based membrane-mimetic two dimensional nanomaterials. United States. doi:10.1117/12.2303685.
Chen, Chunlong. Tue . "Peptoid-based membrane-mimetic two dimensional nanomaterials". United States. doi:10.1117/12.2303685.
@article{osti_1481921,
title = {Peptoid-based membrane-mimetic two dimensional nanomaterials},
author = {Chen, Chunlong},
abstractNote = {This paper presents a review of membrane-mimetic two dimensional (2D) nanomaterials assembled from sequence-defined, diblock-like peptoids through an evaporation-induced crystallization method. Similar to those associated with cell membranes, these peptoid-based nanomembranes exhibit thicknesses in the 3.5 - 5.6 nm range, spontaneous assembly at interfaces, thickness variations in response to changes in Na+ concentrations, and the ability to self-repair. Moreover, they are highly stable, free-standing, and atomically ordered. Both experimental and simulations studies showed that these nanomembranes were formed through an anisotropic formation process. We further demonstrated the incorporation and patterning of a broad range of functional groups within peptoid membranes through large side-chain diversity and/or co-crystallization approaches. By tuning the peptoid hydrophobic domains which determine the stability of nanomembranes, we demonstrated the assembly of single-walled crystalline nanotubes through folding peptoid-based 2D nanomaterials. Given peptoids are biocompatible and easy to synthesize, we anticipate this new class of peptoid-based 2D nanomaterials will provide a robust platform for development of biomimetic materials tailored to specific applications.},
doi = {10.1117/12.2303685},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {5}
}

Conference:
Other availability
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