Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA
Abstract
The administration of chelation therapy to treat significant intakes of actinides, such as plutonium, affects the actinide’s normal biokinetics. In particular, it enhances the actinide’s rate of excretion, such that the standard biokinetic models cannot be applied directly to the chelation-affected bioassay data in order to estimate the intake and assess the radiation dose. Here we propose a new chelation model that can be applied to the chelation-affected bioassay data after plutonium intake via wound and treatment with DTPA. In the proposed model, chelation is assumed to occur in the blood, liver, and parts of the skeleton. Ten datasets, consisting of measurements of 14C-DTPA, 238Pu, and 239Pu involving humans given radiolabeled DTPA and humans occupationally exposed to plutonium via wound and treated with chelation therapy, were used for model development. The combined dataset consisted of daily and cumulative excretion (urine and feces), wound counts, measurements of excised tissue, blood, and post-mortem tissue analyses of liver and skeleton. The combined data were simultaneously fit using the chelation model linked with a plutonium systemic model, which was linked to an ad hoc wound model. The proposed chelation model was used for dose assessment of the wound cases used in this study.
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1739974
- Report Number(s):
- LA-UR-19-28424
Journal ID: ISSN 0017-9078
- Grant/Contract Number:
- 89233218CNA000001
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Health Physics
- Additional Journal Information:
- Journal Volume: 119; Journal Issue: 6; Journal ID: ISSN 0017-9078
- Publisher:
- Health Physics Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; chelation; dosimetry, internal; DTPA; wound; radiation protection; chelation modeling; plutonium decorporation; humans, internal dose
Citation Formats
de Souza Zanotta Dumit, Sara, Miller, Guthrie, Klumpp, John Allan, Poudel, Deepesh, Bertelli, Luiz, and Waters, Tom L. Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA. United States: N. p., 2020.
Web. doi:10.1097/hp.0000000000001282.
de Souza Zanotta Dumit, Sara, Miller, Guthrie, Klumpp, John Allan, Poudel, Deepesh, Bertelli, Luiz, & Waters, Tom L. Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA. United States. https://doi.org/10.1097/hp.0000000000001282
de Souza Zanotta Dumit, Sara, Miller, Guthrie, Klumpp, John Allan, Poudel, Deepesh, Bertelli, Luiz, and Waters, Tom L. Tue .
"Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA". United States. https://doi.org/10.1097/hp.0000000000001282. https://www.osti.gov/servlets/purl/1739974.
@article{osti_1739974,
title = {Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA},
author = {de Souza Zanotta Dumit, Sara and Miller, Guthrie and Klumpp, John Allan and Poudel, Deepesh and Bertelli, Luiz and Waters, Tom L.},
abstractNote = {The administration of chelation therapy to treat significant intakes of actinides, such as plutonium, affects the actinide’s normal biokinetics. In particular, it enhances the actinide’s rate of excretion, such that the standard biokinetic models cannot be applied directly to the chelation-affected bioassay data in order to estimate the intake and assess the radiation dose. Here we propose a new chelation model that can be applied to the chelation-affected bioassay data after plutonium intake via wound and treatment with DTPA. In the proposed model, chelation is assumed to occur in the blood, liver, and parts of the skeleton. Ten datasets, consisting of measurements of 14C-DTPA, 238Pu, and 239Pu involving humans given radiolabeled DTPA and humans occupationally exposed to plutonium via wound and treated with chelation therapy, were used for model development. The combined dataset consisted of daily and cumulative excretion (urine and feces), wound counts, measurements of excised tissue, blood, and post-mortem tissue analyses of liver and skeleton. The combined data were simultaneously fit using the chelation model linked with a plutonium systemic model, which was linked to an ad hoc wound model. The proposed chelation model was used for dose assessment of the wound cases used in this study.},
doi = {10.1097/hp.0000000000001282},
journal = {Health Physics},
number = 6,
volume = 119,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 2020},
month = {Tue Dec 01 00:00:00 EST 2020}
}
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