Development of the Plutonium-DTPA biokinetic model

Konzen, Kevin; Brey, Richard

doi:10.1097/HP.0000000000000283

Title: Development of the Plutonium-DTPA biokinetic model

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Abstract

Estimating radionuclide intakes from bioassays following chelation treatment presents a challenge to the dosimetrist due to the observed excretion enhancement of the particular radionuclide of concern, where no standard biokinetic model exists. This document provides a Pu-DTPA biokinetic model that may be used for making such determination for plutonium intakes. The Pu-DTPA biokinetic model is intended to supplement the standard recommended biokinetic models. The model was used to evaluate several chelation strategies that resulted in providing recommendations for effective treatment. These recommendations supported early treatment for soluble particle inhalations and an initial 3-day treatment series of DTPA treatments for wounds. Several late chelation strategies were also compared where reduced treatment frequencies proved to be as effective as multiple treatments. Furthermore, the Pu-DTPA biokinetic model can be used to assist in estimating initial intakes of transuranic radionuclides, and for studying the effects of different treatment strategies.

Authors:

Konzen, Kevin ^[1]; Brey, Richard ^[2]

CH2-WG Idaho, LLC, Idaho Falls, ID (United States)
Idaho State Univ., Pocatello, ID (United States)

Publication Date:: Mon Jun 01 00:00:00 EDT 2015

Research Org.:: CH2-WG Idaho, LLC, Idaho Falls, ID (United States)

Sponsoring Org.:: USDOE Office of Environmental Management (EM)

Contributing Org.:: Enter names of organizations that provided significant assistance but not direct funding

OSTI Identifier:: 1256081

Grant/Contract Number:: AC07-05ID14516

Resource Type:: Accepted Manuscript

Journal Name:: Health Physics

Additional Journal Information:: Journal Volume: 108; Journal Issue: 6; Related Information: (Provide citations for supplementary items published with journal articles, or any other citation directly supporting the document you are submitting. Or, see the Related DOIs field below.); Journal ID: ISSN 0017-9078

Publisher:: Health Physics Society

Country of Publication:: United States

Language:: English

Subject:: 61 RADIATION PROTECTION AND DOSIMETRY; DTPA; Plutonium; Chelation; Biokinetics

Citation Formats


                    Konzen, Kevin, and Brey, Richard. Development of the Plutonium-DTPA biokinetic model.  United States: N. p., 2015. 
Web.  doi:10.1097/HP.0000000000000283.

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                    Konzen, Kevin, & Brey, Richard. Development of the Plutonium-DTPA biokinetic model.  United States.  https://doi.org/10.1097/HP.0000000000000283

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                    Konzen, Kevin, and Brey, Richard. Mon .  
"Development of the Plutonium-DTPA biokinetic model".  United States.  https://doi.org/10.1097/HP.0000000000000283.  https://www.osti.gov/servlets/purl/1256081.

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@article{osti_1256081,

  title        = {Development of the Plutonium-DTPA biokinetic model},

  author       = {Konzen, Kevin and Brey, Richard},

  abstractNote = {Estimating radionuclide intakes from bioassays following chelation treatment presents a challenge to the dosimetrist due to the observed excretion enhancement of the particular radionuclide of concern, where no standard biokinetic model exists. This document provides a Pu-DTPA biokinetic model that may be used for making such determination for plutonium intakes. The Pu-DTPA biokinetic model is intended to supplement the standard recommended biokinetic models. The model was used to evaluate several chelation strategies that resulted in providing recommendations for effective treatment. These recommendations supported early treatment for soluble particle inhalations and an initial 3-day treatment series of DTPA treatments for wounds. Several late chelation strategies were also compared where reduced treatment frequencies proved to be as effective as multiple treatments. Furthermore, the Pu-DTPA biokinetic model can be used to assist in estimating initial intakes of transuranic radionuclides, and for studying the effects of different treatment strategies.},

  doi          = {10.1097/HP.0000000000000283},

  journal      = {Health Physics},

  number       = 6,

  volume       = 108,

  place        = {United States},

  year         = {Mon Jun 01 00:00:00 EDT 2015},

  month        = {Mon Jun 01 00:00:00 EDT 2015}

}

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