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Title: The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database

Abstract

Background: High birth weight (BW), 4000 g or larger, is an established risk factor for childhood leukemia. However, its association with central nervous system (CNS) tumor risk is yet unclear. The present study examined it, analyzing data obtained from a case-control study conducted among three states from the US. The association with childhood leukemia risk was also further examined. Methods: In this study, a data set provided by the Comprehensive Epidemiologic Data Resource was analyzed with an official permission. The original case-control study was conducted to examine the association between paternal preconception exposure to ionizing radiation and childhood cancer risk. Cases with childhood cancer were mainly ascertained from local hospitals, and controls were selected, matched with birth year (1-year category), county of residence, sex, ethnicity and maternal age (+/-2 years). Since the ID numbers were unavailable, conventional logistic analyses were conducted adjusting for those matching variables except for the county of residence. In addition to those variables, gestational age, age at diagnosis and study sites as covariables were included in the logistic models. Results: Analyzed subjects were 72 CNS tumor cases, 124 leukemia cases and 822 controls born from 1945 to 1989. The odds ratios (ORs) of CNS tumor riskmore » for children with low BWs (<2500 g) and high BWs (>4000 g) were 2.0 (95% confidence interval [CI]) = 0.7, 5.9) and 2.5 (95%CI = 1.2, 5.2)], respectively. When high-BW children were restricted to those who were large for gestational age (LGA), the OR for high-BW children remained similar (OR = 2.7; 95%CI = 1.1, 6.2). On the other hand, the ORs of leukemia risk for children with low and high BWs were 0.8 (95%CI = 0.2, 3.0) and 1.4 (95%CI = 0.7, 2.6), respectively. In the normal range of BW (2500–4000 g), higher BW was positively associated with CNS tumor risk (beta = 0.0011, p for trend = 0.012). However, the association with leukemia risk was not significant (beta = -0.0002, p for trend = 0.475). Conclusion: High-BW and LGA children had an elevated childhood CNS tumor risk. In the normal BW range, the BW itself was positively related to CNS tumor risk. No significant association between BW and childhood leukemia risk was observed in this study.« less

Authors:
 [1];  [1];  [1];  [1];  [1]
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  1. Kagoshima Univ., Kagoshima (Japan). Dept. of Epidemiology and Preventive Medicine
Publication Date:
Research Org.:
Kagoshima Univ., Kagoshima (Japan)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1626863
Grant/Contract Number:  
FG02-00ER41132
Resource Type:
Accepted Manuscript
Journal Name:
BMC Cancer
Additional Journal Information:
Journal Volume: 17; Journal Issue: 1; Journal ID: ISSN 1471-2407
Publisher:
BioMed Central
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Oncology; Childhood cancer; Leukemia; CNS tumors; Birth weight

Citation Formats

Tran, Long Thanh, Lai, Hang Thi Minh, Koriyama, Chihaya, Uwatoko, Futoshi, and Akiba, Suminori. The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database. United States: N. p., 2017. Web. doi:10.1186/s12885-017-3681-y.
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Tran, Long Thanh, Lai, Hang Thi Minh, Koriyama, Chihaya, Uwatoko, Futoshi, & Akiba, Suminori. The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database. United States. https://doi.org/10.1186/s12885-017-3681-y
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Tran, Long Thanh, Lai, Hang Thi Minh, Koriyama, Chihaya, Uwatoko, Futoshi, and Akiba, Suminori. Mon . "The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database". United States. https://doi.org/10.1186/s12885-017-3681-y. https://www.osti.gov/servlets/purl/1626863.
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@article{osti_1626863,
title = {The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database},
author = {Tran, Long Thanh and Lai, Hang Thi Minh and Koriyama, Chihaya and Uwatoko, Futoshi and Akiba, Suminori},
abstractNote = {Background: High birth weight (BW), 4000 g or larger, is an established risk factor for childhood leukemia. However, its association with central nervous system (CNS) tumor risk is yet unclear. The present study examined it, analyzing data obtained from a case-control study conducted among three states from the US. The association with childhood leukemia risk was also further examined. Methods: In this study, a data set provided by the Comprehensive Epidemiologic Data Resource was analyzed with an official permission. The original case-control study was conducted to examine the association between paternal preconception exposure to ionizing radiation and childhood cancer risk. Cases with childhood cancer were mainly ascertained from local hospitals, and controls were selected, matched with birth year (1-year category), county of residence, sex, ethnicity and maternal age (+/-2 years). Since the ID numbers were unavailable, conventional logistic analyses were conducted adjusting for those matching variables except for the county of residence. In addition to those variables, gestational age, age at diagnosis and study sites as covariables were included in the logistic models. Results: Analyzed subjects were 72 CNS tumor cases, 124 leukemia cases and 822 controls born from 1945 to 1989. The odds ratios (ORs) of CNS tumor risk for children with low BWs (<2500 g) and high BWs (>4000 g) were 2.0 (95% confidence interval [CI]) = 0.7, 5.9) and 2.5 (95%CI = 1.2, 5.2)], respectively. When high-BW children were restricted to those who were large for gestational age (LGA), the OR for high-BW children remained similar (OR = 2.7; 95%CI = 1.1, 6.2). On the other hand, the ORs of leukemia risk for children with low and high BWs were 0.8 (95%CI = 0.2, 3.0) and 1.4 (95%CI = 0.7, 2.6), respectively. In the normal range of BW (2500–4000 g), higher BW was positively associated with CNS tumor risk (beta = 0.0011, p for trend = 0.012). However, the association with leukemia risk was not significant (beta = -0.0002, p for trend = 0.475). Conclusion: High-BW and LGA children had an elevated childhood CNS tumor risk. In the normal BW range, the BW itself was positively related to CNS tumor risk. No significant association between BW and childhood leukemia risk was observed in this study.},
doi = {10.1186/s12885-017-3681-y},
journal = {BMC Cancer},
number = 1,
volume = 17,
place = {United States},
year = {Mon Oct 16 00:00:00 EDT 2017},
month = {Mon Oct 16 00:00:00 EDT 2017}
}
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Publisher's Version of Record
https://doi.org/10.1186/s12885-017-3681-y
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Figures / Tables:

Table 1 Table 1: Characteristics of cases and controls by factors matched (or surrogate factors) in the original study
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journal, April 2003

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  • International Journal of Epidemiology, Vol. 32, Issue 2
  • DOI: 10.1093/ije/dyg057

Socioeconomic status and childhood leukaemia: a review
journal, November 2005

  • Poole, Charles; Greenland, Sander; Luetters, Crystal
  • International Journal of Epidemiology, Vol. 35, Issue 2
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Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases
journal, January 2015

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Birth Weight and Risk for Childhood Leukemia in Denmark, Sweden, Norway, and Iceland
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Risk factors for central nervous system tumors in children: New findings from a case-control study
journal, February 2017

Fetal Growth and Childhood Cancer: A Population-Based Study
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  • Bjørge, Tone; Sørensen, Henrik Toft; Grotmol, Tom
  • Pediatrics, Vol. 132, Issue 5
  • DOI: 10.1542/peds.2013-1317
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