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Title: The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study

Abstract

Background Selenium (Se) is an essential trace element for the human body. Serum Se and urinary Se are also biomarkers to assess Se exposure status. However, studies focusing on the association between urinary Se and the risk of gestational diabetes mellitus (GDM) are rare. Objective To investigate the association between urinary Se and the risk of GDM. Methods A nested case–control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children’s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed. Results Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interactionmore » with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses. Discussion Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.« less

Authors:
; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI Identifier:
1963361
Resource Type:
Published Article
Journal Name:
Frontiers in Public Health
Additional Journal Information:
Journal Name: Frontiers in Public Health Journal Volume: 11; Journal ID: ISSN 2296-2565
Publisher:
Frontiers Media SA
Country of Publication:
Switzerland
Language:
English

Citation Formats

Liu, Yuanxia, Chen, Hongmei, Zhang, Mengtian, Zhu, Gangjiao, Yang, Yan, Li, Yuanyuan, Lu, Wei, and Zhang, Hongling. The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study. Switzerland: N. p., 2023. Web. doi:10.3389/fpubh.2023.1145113.
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Liu, Yuanxia, Chen, Hongmei, Zhang, Mengtian, Zhu, Gangjiao, Yang, Yan, Li, Yuanyuan, Lu, Wei, & Zhang, Hongling. The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study. Switzerland. https://doi.org/10.3389/fpubh.2023.1145113
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Liu, Yuanxia, Chen, Hongmei, Zhang, Mengtian, Zhu, Gangjiao, Yang, Yan, Li, Yuanyuan, Lu, Wei, and Zhang, Hongling. Mon . "The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study". Switzerland. https://doi.org/10.3389/fpubh.2023.1145113.
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@article{osti_1963361,
title = {The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study},
author = {Liu, Yuanxia and Chen, Hongmei and Zhang, Mengtian and Zhu, Gangjiao and Yang, Yan and Li, Yuanyuan and Lu, Wei and Zhang, Hongling},
abstractNote = {Background Selenium (Se) is an essential trace element for the human body. Serum Se and urinary Se are also biomarkers to assess Se exposure status. However, studies focusing on the association between urinary Se and the risk of gestational diabetes mellitus (GDM) are rare. Objective To investigate the association between urinary Se and the risk of GDM. Methods A nested case–control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children’s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed. Results Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interaction with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses. Discussion Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.},
doi = {10.3389/fpubh.2023.1145113},
journal = {Frontiers in Public Health},
number = ,
volume = 11,
place = {Switzerland},
year = {Mon Mar 27 00:00:00 EDT 2023},
month = {Mon Mar 27 00:00:00 EDT 2023}
}
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https://doi.org/10.3389/fpubh.2023.1145113
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