Matter-wave interference of a native polypeptide
Abstract
The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.
- Authors:
-
[1];
[1]
- Univ. of Vienna (Austria)
- Imperial College, London (United Kingdom)
- Stanford Univ., CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)
- Publication Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE; Austrian Science Fund (FWF); European Research Council (ERC); National Science Foundation (NSF)
- OSTI Identifier:
- 1616995
- Grant/Contract Number:
- AC02-76SF00515; 320694; TG-MCB090110
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Atomic and molecular interactions with photons; Mass spectrometry; Matter waves and particle beams
Citation Formats
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Matter-wave interference of a native polypeptide. United States: N. p., 2020.
Web. doi:10.1038/s41467-020-15280-2.
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., & Arndt, M. Matter-wave interference of a native polypeptide. United States. https://doi.org/10.1038/s41467-020-15280-2
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Thu .
"Matter-wave interference of a native polypeptide". United States. https://doi.org/10.1038/s41467-020-15280-2. https://www.osti.gov/servlets/purl/1616995.
@article{osti_1616995,
title = {Matter-wave interference of a native polypeptide},
author = {Shayeghi, A. and Rieser, P. and Richter, G. and Sezer, U. and Rodewald, J. H. and Geyer, P. and Martinez, T. J. and Arndt, M.},
abstractNote = {The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.},
doi = {10.1038/s41467-020-15280-2},
journal = {Nature Communications},
number = 1,
volume = 11,
place = {United States},
year = {Thu Mar 19 00:00:00 EDT 2020},
month = {Thu Mar 19 00:00:00 EDT 2020}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 15 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Influence of conformational molecular dynamics on matter wave interferometry
journal, March 2010
- Gring, Michael; Gerlich, Stefan; Eibenberger, Sandra
- Physical Review A, Vol. 81, Issue 3
Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
journal, December 2018
- Schätti, Jonas; Rieser, Philipp; Sezer, Ugur
- Communications Chemistry, Vol. 1, Issue 1
Generating Efficient Quantum Chemistry Codes for Novel Architectures
journal, November 2012
- Titov, Alexey V.; Ufimtsev, Ivan S.; Luehr, Nathan
- Journal of Chemical Theory and Computation, Vol. 9, Issue 1
Quantum Test of the Universality of Free Fall
journal, May 2014
- Schlippert, D.; Hartwig, J.; Albers, H.
- Physical Review Letters, Vol. 112, Issue 20
Density-functional exchange-energy approximation with correct asymptotic behavior
journal, September 1988
- Becke, A. D.
- Physical Review A, Vol. 38, Issue 6
A universal matter-wave interferometer with optical ionization gratings in the time domain
journal, February 2013
- Haslinger, Philipp; Dörre, Nadine; Geyer, Philipp
- Nature Physics, Vol. 9, Issue 3
Interleaved atom interferometry for high-sensitivity inertial measurements
journal, December 2018
- Savoie, D.; Altorio, M.; Fang, B.
- Science Advances, Vol. 4, Issue 12
Laser Desorption/Ionization Mass Spectrometry of Proteins of Mass 100 000 to 250 000 Dalton
journal, June 1989
- Karas, Michael; Bahr, Ute; Ingendoh, Arndt
- Angewandte Chemie International Edition in English, Vol. 28, Issue 6
On the Quantum Correction For Thermodynamic Equilibrium
journal, June 1932
- Wigner, E.
- Physical Review, Vol. 40, Issue 5
Measurement of the fine-structure constant as a test of the Standard Model
journal, April 2018
- Parker, Richard H.; Yu, Chenghui; Zhong, Weicheng
- Science, Vol. 360, Issue 6385
Quantum-Assisted Metrology of Neutral Vitamins in the Gas Phase
journal, July 2017
- Mairhofer, Lukas; Eibenberger, Sandra; Cotter, Joseph P.
- Angewandte Chemie International Edition, Vol. 56, Issue 36
Testing spontaneous localization theories with matter-wave interferometry
journal, April 2011
- Nimmrichter, Stefan; Hornberger, Klaus; Haslinger, Philipp
- Physical Review A, Vol. 83, Issue 4
Isotope-selective high-order interferometry with large organic molecules in free fall
journal, March 2018
- Rodewald, Jonas; Dörre, Nadine; Grimaldi, Andrea
- New Journal of Physics, Vol. 20, Issue 3
De Broglie’s meter stick: Making measurements with matter waves
journal, May 2014
- Arndt, Markus
- Physics Today, Vol. 67, Issue 5
Choosing a density functional for static molecular polarizabilities
journal, August 2015
- Wu, Taozhe; Kalugina, Yulia N.; Thakkar, Ajit J.
- Chemical Physics Letters, Vol. 635
Ion formation mechanisms in UV-MALDI
journal, January 2006
- Knochenmuss, Richard
- The Analyst, Vol. 131, Issue 9
New avenues for matter-wave-enhanced spectroscopy
journal, December 2016
- Rodewald, Jonas; Haslinger, Philipp; Dörre, Nadine
- Applied Physics B, Vol. 123, Issue 1
Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density
journal, January 1988
- Lee, Chengteh; Yang, Weitao; Parr, Robert G.
- Physical Review B, Vol. 37, Issue 2
A long-range-corrected density functional that performs well for both ground-state properties and time-dependent density functional theory excitation energies, including charge-transfer excited states
journal, February 2009
- Rohrdanz, Mary A.; Martins, Katie M.; Herbert, John M.
- The Journal of Chemical Physics, Vol. 130, Issue 5
Tailoring the volatility and stability of oligopeptides: Fluorous tags
journal, July 2017
- Schätti, J.; Sezer, U.; Pedalino, S.
- Journal of Mass Spectrometry, Vol. 52, Issue 8
A density matrix-based method for the linear-scaling calculation of dynamic second- and third-order properties at the Hartree-Fock and Kohn-Sham density functional theory levels
journal, November 2007
- Kussmann, Jörg; Ochsenfeld, Christian
- The Journal of Chemical Physics, Vol. 127, Issue 20
Quantum test of the equivalence principle for atoms in coherent superposition of internal energy states
journal, June 2017
- Rosi, G.; D’Amico, G.; Cacciapuoti, L.
- Nature Communications, Vol. 8, Issue 1
Detecting inertial effects with airborne matter-wave interferometry
journal, September 2011
- Geiger, R.; Ménoret, V.; Stern, G.
- Nature Communications, Vol. 2, Issue 1
Quantum superposition of molecules beyond 25 kDa
journal, September 2019
- Fein, Yaakov Y.; Geyer, Philipp; Zwick, Patrick
- Nature Physics, Vol. 15, Issue 12
Atom-interferometry constraints on dark energy
journal, August 2015
- Hamilton, P.; Jaffe, M.; Haslinger, P.
- Science, Vol. 349, Issue 6250
Quantum Chemistry on Graphical Processing Units. 3. Analytical Energy Gradients, Geometry Optimization, and First Principles Molecular Dynamics
journal, August 2009
- Ufimtsev, Ivan S.; Martinez, Todd J.
- Journal of Chemical Theory and Computation, Vol. 5, Issue 10
Concept of an ionizing time-domain matter-wave interferometer
journal, July 2011
- Nimmrichter, Stefan; Haslinger, Philipp; Hornberger, Klaus
- New Journal of Physics, Vol. 13, Issue 7
Q-Chem: an engine for innovation: Q-Chem: an engine for innovation
journal, November 2012
- Krylov, Anna I.; Gill, Peter M. W.
- Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 3, Issue 3
Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989
- Fenn, J.; Mann, M.; Meng, C.
- Science, Vol. 246, Issue 4926, p. 64-71
Quantum superposition at the half-metre scale
journal, December 2015
- Kovachy, T.; Asenbaum, P.; Overstreet, C.
- Nature, Vol. 528, Issue 7583
Theory of near-field matter-wave interference beyond the eikonal approximation
journal, August 2008
- Nimmrichter, Stefan; Hornberger, Klaus
- Physical Review A, Vol. 78, Issue 2
Wave–particle duality of C60 molecules
journal, October 1999
- Arndt, Markus; Nairz, Olaf; Vos-Andreae, Julian
- Nature, Vol. 401, Issue 6754
Absolute Absorption Cross Sections from Photon Recoil in a Matter-Wave Interferometer
journal, June 2014
- Eibenberger, Sandra; Cheng, Xiaxi; Cotter, J. P.
- Physical Review Letters, Vol. 112, Issue 25
Structure of Isolated Biomolecules by Electron Diffraction−Laser Desorption: Uracil and Guanine
journal, March 2009
- Gahlmann, Andreas; Park, Sang Tae; Zewail, Ahmed H.
- Journal of the American Chemical Society, Vol. 131, Issue 8
P EPTIDES AND P ROTEINS IN THE V APOR P HASE
journal, October 2000
- Jarrold, Martin F.
- Annual Review of Physical Chemistry, Vol. 51, Issue 1
Theory of decoherence in a matter wave Talbot-Lau interferometer
journal, November 2004
- Hornberger, Klaus; Sipe, John E.; Arndt, Markus
- Physical Review A, Vol. 70, Issue 5
UV and VUV Ionization of Organic Molecules, Clusters, and Complexes
journal, September 2009
- Marksteiner, Markus; Haslinger, Philipp; Sclafani, Michele
- The Journal of Physical Chemistry A, Vol. 113, Issue 37
Laser Desorption/Ionization Mass Spectrometry of Proteins of Mass 100 000 to 250 000 Dalton
journal, June 1989
- Karas, Michael; Bahr, Ute; Ingendoh, Arndt
- Angewandte Chemie International Edition in English, Vol. 28, Issue 6
Q-Chem: an engine for innovation: Q-Chem: an engine for innovation
journal, November 2012
- Krylov, Anna I.; Gill, Peter M. W.
- Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 3, Issue 3
Choosing a density functional for static molecular polarizabilities
journal, August 2015
- Wu, Taozhe; Kalugina, Yulia N.; Thakkar, Ajit J.
- Chemical Physics Letters, Vol. 635
Structure and function of a novel antioxidant peptide from the skin of tropical frogs
journal, February 2018
- Barbosa, Eder Alves; Oliveira, Ana; Plácido, Alexandra
- Free Radical Biology and Medicine, Vol. 115
Quantum Chemistry on Graphical Processing Units. 3. Analytical Energy Gradients, Geometry Optimization, and First Principles Molecular Dynamics
journal, August 2009
- Ufimtsev, Ivan S.; Martinez, Todd J.
- Journal of Chemical Theory and Computation, Vol. 5, Issue 10
Structure of Isolated Biomolecules by Electron Diffraction−Laser Desorption: Uracil and Guanine
journal, March 2009
- Gahlmann, Andreas; Park, Sang Tae; Zewail, Ahmed H.
- Journal of the American Chemical Society, Vol. 131, Issue 8
Quantum superposition at the half-metre scale
journal, December 2015
- Kovachy, T.; Asenbaum, P.; Overstreet, C.
- Nature, Vol. 528, Issue 7583
Detecting inertial effects with airborne matter-wave interferometry
journal, September 2011
- Geiger, R.; Ménoret, V.; Stern, G.
- Nature Communications, Vol. 2, Issue 1
Quantum test of the equivalence principle for atoms in coherent superposition of internal energy states
journal, June 2017
- Rosi, G.; D’Amico, G.; Cacciapuoti, L.
- Nature Communications, Vol. 8, Issue 1
A universal matter-wave interferometer with optical ionization gratings in the time domain
journal, February 2013
- Haslinger, Philipp; Dörre, Nadine; Geyer, Philipp
- Nature Physics, Vol. 9, Issue 3
Quantum superposition of molecules beyond 25 kDa
journal, September 2019
- Fein, Yaakov Y.; Geyer, Philipp; Zwick, Patrick
- Nature Physics, Vol. 15, Issue 12
Ion formation mechanisms in UV-MALDI
journal, January 2006
- Knochenmuss, Richard
- The Analyst, Vol. 131, Issue 9
A density matrix-based method for the linear-scaling calculation of dynamic second- and third-order properties at the Hartree-Fock and Kohn-Sham density functional theory levels
journal, November 2007
- Kussmann, Jörg; Ochsenfeld, Christian
- The Journal of Chemical Physics, Vol. 127, Issue 20
A long-range-corrected density functional that performs well for both ground-state properties and time-dependent density functional theory excitation energies, including charge-transfer excited states
journal, February 2009
- Rohrdanz, Mary A.; Martins, Katie M.; Herbert, John M.
- The Journal of Chemical Physics, Vol. 130, Issue 5
Macroscopicity of Mechanical Quantum Superposition States
journal, April 2013
- Nimmrichter, Stefan; Hornberger, Klaus
- Physical Review Letters, Vol. 110, Issue 16
Phase Shift in an Atom Interferometer due to Spacetime Curvature across its Wave Function
journal, May 2017
- Asenbaum, Peter; Overstreet, Chris; Kovachy, Tim
- Physical Review Letters, Vol. 118, Issue 18
Optics and interferometry with atoms and molecules
journal, July 2009
- Cronin, Alexander D.; Schmiedmayer, Jörg; Pritchard, David E.
- Reviews of Modern Physics, Vol. 81, Issue 3
Interleaved Atom Interferometry for High Sensitivity Inertial Measurements
conference, April 2019
- Savoie, D.; Altorio, M.; Fang, B.
- 2019 Joint Conference of the IEEE International Frequency Control Symposium anEuropean Frequency and Time Forum (EFTF/IFC), 2019 Joint Conference of the IEEE International Frequency Control Symposium and European Frequency and Time Forum (EFTF/IFC)
Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989
- Fenn, J.; Mann, M.; Meng, C.
- Science, Vol. 246, Issue 4926, p. 64-71
P EPTIDES AND P ROTEINS IN THE V APOR P HASE
journal, October 2000
- Jarrold, Martin F.
- Annual Review of Physical Chemistry, Vol. 51, Issue 1
Quantum tests of the universality of free fall
text, January 2014
- Schlippert, Dennis
- Hannover : Gottfried Wilhelm Leibniz Universität Hannover
Theory of near-field matter wave interference beyond the eikonal approximation
text, January 2008
- Nimmrichter, Stefan; Hornberger, Klaus
- arXiv
Testing spontaneous localization theories with matter-wave interferometry
text, January 2011
- Nimmrichter, Stefan; Hornberger, Klaus; Haslinger, Philipp
- arXiv
Isotope-selective high-order interferometry with large organic molecules in free fall
text, January 2018
- Rodewald, Jonas; Dörre, Nadine; Grimaldi, Andrea
- Karlsruhe
Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
text, January 2018
- Schätti, J.; Rieser, P.; Sezer, U.
- Karlsruhe
Works referencing / citing this record:
Quantum superposition of massive objects and collapse models
journal, November 2011
- Romero-Isart, Oriol
- Physical Review A, Vol. 84, Issue 5
A universal matter-wave interferometer with optical ionization gratings in the time domain
journal, February 2013
- Haslinger, Philipp; Dörre, Nadine; Geyer, Philipp
- Nature Physics, Vol. 9, Issue 3
Testing the limits of quantum mechanical superpositions
journal, April 2014
- Arndt, Markus; Hornberger, Klaus
- Nature Physics, Vol. 10, Issue 4
Near-field interferometry of a free-falling nanoparticle from a point-like source
journal, September 2014
- Bateman, James; Nimmrichter, Stefan; Hornberger, Klaus
- Nature Communications, Vol. 5, Issue 1
The Schrödinger–Newton equations beyond Newton
journal, January 2015
- Manfredi, Giovanni
- General Relativity and Gravitation, Vol. 47, Issue 2
Upper Bounds on Spontaneous Wave-Function Collapse Models Using Millikelvin-Cooled Nanocantilevers
journal, March 2016
- Vinante, A.; Bahrami, M.; Bassi, A.
- Physical Review Letters, Vol. 116, Issue 9
Isotope-selective high-order interferometry with large organic molecules in free fall
text, January 2018
- Rodewald, Jonas; Dörre, Nadine; Grimaldi, Andrea
- IOP Publishing
Stochastic extensions of the regularized Schrödinger-Newton equation
journal, January 2015
- Nimmrichter, Stefan; Hornberger, Klaus
- Physical Review D, Vol. 91, Issue 2
Macroscopic quantum states: Measures, fragility, and implementations
journal, May 2018
- Fröwis, Florian; Sekatski, Pavel; Dür, Wolfgang
- Reviews of Modern Physics, Vol. 90, Issue 2
Experimental methods of molecular matter-wave optics
journal, August 2013
- Juffmann, Thomas; Ulbricht, Hendrik; Arndt, Markus
- Reports on Progress in Physics, Vol. 76, Issue 8
Macroscopic quantum resonators (MAQRO): Testing quantum and gravitational physics with massive mechanical resonators
journal, March 2012
- Kaltenbaek, Rainer; Hechenblaikner, Gerald; Kiesel, Nikolai
- Experimental Astronomy, Vol. 34, Issue 2
Optomechanical Sensing of Spontaneous Wave-Function Collapse
journal, July 2014
- Nimmrichter, Stefan; Hornberger, Klaus; Hammerer, Klemens
- Physical Review Letters, Vol. 113, Issue 2
Displacemon Electromechanics: How to Detect Quantum Interference in a Nanomechanical Resonator
journal, May 2018
- Khosla, K. E.; Vanner, M. R.; Ares, N.
- Physical Review X, Vol. 8, Issue 2
Observation of Generalized Optomechanical Coupling and Cooling on Cavity Resonance
journal, January 2015
- Sawadsky, Andreas; Kaufer, Henning; Nia, Ramon Moghadas
- Physical Review Letters, Vol. 114, Issue 4
Testing the quantum superposition principle in the frequency domain
journal, March 2014
- Bahrami, M.; Bassi, A.; Ulbricht, H.
- Physical Review A, Vol. 89, Issue 3
Cavity cooling of free silicon nanoparticles in high vacuum
journal, November 2013
- Asenbaum, Peter; Kuhn, Stefan; Nimmrichter, Stefan
- Nature Communications, Vol. 4, Issue 1
Refined model for Talbot–Lau matter-wave optics with pulsed photodepletion gratings
journal, December 2014
- Dörre, Nadine; Haslinger, Philipp; Rodewald, Jonas
- Journal of the Optical Society of America B, Vol. 32, Issue 1
Quantum superposition of molecules beyond 25 kDa
journal, September 2019
- Fein, Yaakov Y.; Geyer, Philipp; Zwick, Patrick
- Nature Physics, Vol. 15, Issue 12
Cooling and manipulation of nanoparticles in high vacuum
conference, September 2016
- Millen, J.; Kuhn, S.; Patolsky, F.
- SPIE Nanoscience + Engineering, SPIE Proceedings
Models of wave-function collapse, underlying theories, and experimental tests
journal, April 2013
- Bassi, Angelo; Lochan, Kinjalk; Satin, Seema
- Reviews of Modern Physics, Vol. 85, Issue 2
Dissipative Continuous Spontaneous Localization (CSL) model
journal, August 2015
- Smirne, Andrea; Bassi, Angelo
- Scientific Reports, Vol. 5, Issue 1
Dissipative extension of the Ghirardi-Rimini-Weber model
journal, December 2014
- Smirne, Andrea; Vacchini, Bassano; Bassi, Angelo
- Physical Review A, Vol. 90, Issue 6
Large Quantum Superpositions and Interference of Massive Nanometer-Sized Objects
journal, July 2011
- Romero-Isart, O.; Pflanzer, A. C.; Blaser, F.
- Physical Review Letters, Vol. 107, Issue 2
Decoherence as a way to measure extremely soft collisions with dark matter
journal, July 2017
- Riedel, C. Jess; Yavin, Itay
- Physical Review D, Vol. 96, Issue 2
Bounds on quantum collapse models from matter-wave interferometry: calculational details
journal, February 2018
- Toroš, Marko; Bassi, Angelo
- Journal of Physics A: Mathematical and Theoretical, Vol. 51, Issue 11
Colloquium : Quantum interference of clusters and molecules
journal, February 2012
- Hornberger, Klaus; Gerlich, Stefan; Haslinger, Philipp
- Reviews of Modern Physics, Vol. 84, Issue 1
Selective Linear or Quadratic Optomechanical Coupling via Measurement
journal, November 2011
- Vanner, Michael R.
- Physical Review X, Vol. 1, Issue 2
Possible role of gravity in collapse of the wave-function: a brief survey of some ideas
journal, July 2015
- Singh, Tejinder P.
- Journal of Physics: Conference Series, Vol. 626