Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties

Dong, Fuping; Firkowska-Boden, Izabela; Arras, Matthias M. L.; Jandt, Klaus. D.

doi:10.1039/c6ra25353a

Title: Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties

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Abstract

Here, the ability to integrate both high encapsulation efficiency and controlled release in a drug delivery system (DDS) is a highly sought solution to cure major diseases. However, creation of such a system is challenging. This study was aimed at constructing a new delivery system based on thermoresponsive poly(N-isopropylacrylamide-co-styrene) (PNIPAAm-co-PS) hollow microspheres prepared via two-step precipitation polymerization. To control the diffusion-driven drug release, the PNIPAAm-co-PS spheres were electrostatically coated with graphene oxide (GO) nanosheets. As a result of the coating the permeability of such copolymer-GO hybrid microspheres was reduced to the extent that suppressed the initial burst release and enabled sustained drug release in in vitro testing. The hybrid microspheres showed improved drug encapsulation by 46.4% which was attributed to the diffusion barrier properties and -conjugated structure of GO. The system presented here is promising to advance, e.g., the anticancer drug delivery technologies by enabling sustained drug release and thus minimizing local and systemic side effects.

Authors:

Dong, Fuping ^[1]; Firkowska-Boden, Izabela ^[2]; Arras, Matthias M. L. ^[3]; Jandt, Klaus. D. ^[2]

Friedrich Schiller Univ. Jena, Jena (Germany); Guizhou Univ., Guiyang (China)
Friedrich Schiller Univ. Jena, Jena (Germany)
Friedrich Schiller Univ. Jena, Jena (Germany); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Publication Date:: Fri Jan 13 00:00:00 EST 2017

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)

Sponsoring Org.:: USDOE Laboratory Directed Research and Development (LDRD) Program

OSTI Identifier:: 1342684

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: RSC Advances

Additional Journal Information:: Journal Volume: 7; Journal Issue: 7; Journal ID: ISSN 2046-2069

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; Drug-Delivery Graphene Responsive Hollowsphere carrier Drug

Citation Formats


                    Dong, Fuping, Firkowska-Boden, Izabela, Arras, Matthias M. L., and Jandt, Klaus. D. Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties.  United States: N. p., 2017. 
Web.  doi:10.1039/c6ra25353a.

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                    Dong, Fuping, Firkowska-Boden, Izabela, Arras, Matthias M. L., & Jandt, Klaus. D. Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties.  United States.  https://doi.org/10.1039/c6ra25353a

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                    Dong, Fuping, Firkowska-Boden, Izabela, Arras, Matthias M. L., and Jandt, Klaus. D. Fri .  
"Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties".  United States.  https://doi.org/10.1039/c6ra25353a.  https://www.osti.gov/servlets/purl/1342684.

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@article{osti_1342684,

  title        = {Responsive copolymer–graphene oxide hybrid microspheres with enhanced drug release properties},

  author       = {Dong, Fuping and Firkowska-Boden, Izabela and Arras, Matthias M. L. and Jandt, Klaus. D.},

  abstractNote = {Here, the ability to integrate both high encapsulation efficiency and controlled release in a drug delivery system (DDS) is a highly sought solution to cure major diseases. However, creation of such a system is challenging. This study was aimed at constructing a new delivery system based on thermoresponsive poly(N-isopropylacrylamide-co-styrene) (PNIPAAm-co-PS) hollow microspheres prepared via two-step precipitation polymerization. To control the diffusion-driven drug release, the PNIPAAm-co-PS spheres were electrostatically coated with graphene oxide (GO) nanosheets. As a result of the coating the permeability of such copolymer-GO hybrid microspheres was reduced to the extent that suppressed the initial burst release and enabled sustained drug release in in vitro testing. The hybrid microspheres showed improved drug encapsulation by 46.4% which was attributed to the diffusion barrier properties and -conjugated structure of GO. The system presented here is promising to advance, e.g., the anticancer drug delivery technologies by enabling sustained drug release and thus minimizing local and systemic side effects.},

  doi          = {10.1039/c6ra25353a},

  journal      = {RSC Advances},

  number       = 7,

  volume       = 7,

  place        = {United States},

  year         = {Fri Jan 13 00:00:00 EST 2017},

  month        = {Fri Jan 13 00:00:00 EST 2017}

}

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