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Title: Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

Abstract

Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

Authors:
;  [1];  [2]
  1. Department of Applied Chemistry, University of Johannesburg, Doornforntein, 2028, Johannesburg (South Africa)
  2. (South Africa)
Publication Date:
OSTI Identifier:
22391859
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1664; Journal Issue: 1; Conference: PPS-30: 30. International Conference of the Polymer Processing Society, Cleveland, OH (United States), 6-12 Jun 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ABSORPTION SPECTROSCOPY; ACETATES; COMPOSITE MATERIALS; DIFFUSION; DOXORUBICIN; EVAPORATION; FOURIER TRANSFORMATION; IRON OXIDES; MAGNETIC FIELDS; MANGANESE PHOSPHIDES; NANOPARTICLES; PH VALUE; PHOSPHATES; SCANNING ELECTRON MICROSCOPY; SYNTHESIS; THERMAL GRAVIMETRIC ANALYSIS

Citation Formats

Mhlanga, Nikiwe, Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001. Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery. United States: N. p., 2015. Web. doi:10.1063/1.4918443.
Mhlanga, Nikiwe, Ray, Suprakas Sinha, & DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001. Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery. United States. doi:10.1063/1.4918443.
Mhlanga, Nikiwe, Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001. Fri . "Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery". United States. doi:10.1063/1.4918443.
@article{osti_22391859,
title = {Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery},
author = {Mhlanga, Nikiwe and Ray, Suprakas Sinha and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001},
abstractNote = {Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.},
doi = {10.1063/1.4918443},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1664,
place = {United States},
year = {2015},
month = {5}
}