A biokinetic model for systemic nickel

Melo, Dunstana; Leggett, Richard Wayne

doi:10.1097/HP.0000000000000579

Title: A biokinetic model for systemic nickel

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Abstract

The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.

Authors:

Melo, Dunstana ^[1]; Leggett, Richard Wayne ^[2]

Melohill Technology LLC, Rockville, MD (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Publication Date:: Sun Jan 01 00:00:00 EST 2017

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: Work for Others (WFO)

OSTI Identifier:: 1336598

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: Health Physics

Additional Journal Information:: Journal Volume: 112; Journal Issue: 1; Journal ID: ISSN 0017-9078

Publisher:: Health Physics Society

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; biokinetics nickel occupational exposure radionuclides

Citation Formats


                    Melo, Dunstana, and Leggett, Richard Wayne. A biokinetic model for systemic nickel.  United States: N. p., 2017. 
Web.  doi:10.1097/HP.0000000000000579.

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                    Melo, Dunstana, & Leggett, Richard Wayne. A biokinetic model for systemic nickel.  United States.  https://doi.org/10.1097/HP.0000000000000579

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                    Melo, Dunstana, and Leggett, Richard Wayne. Sun .  
"A biokinetic model for systemic nickel".  United States.  https://doi.org/10.1097/HP.0000000000000579.  https://www.osti.gov/servlets/purl/1336598.

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@article{osti_1336598,

  title        = {A biokinetic model for systemic nickel},

  author       = {Melo, Dunstana and Leggett, Richard Wayne},

  abstractNote = {The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.},

  doi          = {10.1097/HP.0000000000000579},

  journal      = {Health Physics},

  number       = 1,

  volume       = 112,

  place        = {United States},

  year         = {Sun Jan 01 00:00:00 EST 2017},

  month        = {Sun Jan 01 00:00:00 EST 2017}

}

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