A biokinetic model for systemic technetium in adult humans
Abstract
The International Commission on Radiological Protection (ICRP) currently is updating its biokinetic and dosimetric models for internally deposited radionuclides. Technetium (Tc), the lightest element that exists only in radioactive form, has two important isotopes from the standpoint of potential risk to humans: the long-lived isotope 99Tm(T1/2=2.1x105 y) is present in high concentration in nuclear waste, and the short-lived isotope 99mTc (T1/2=6.02 h) is the most commonly used radionuclide in diagnostic nuclear medicine. This paper reviews data on the biological behavior of technetium and proposes a biokinetic model for systemic technetium in the adult human body for use in radiation protection. Compared with the ICRP s current occupational model for systemic technetium, the proposed model provides a more realistic description of the paths of movement of technetium in the body; provides greater consistency with experimental and medical data; and, for most radiosensitive organs, yields substantially different estimates of cumulative activity (total radioactive decays within the organ) following uptake of 99Tm or 99mTc to blood.
- Authors:
-
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Federal Office for Radiation Protection, Oberschleisheim (Germany)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1213986
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Radiological Protection
- Additional Journal Information:
- Journal Volume: 35; Journal Issue: 2; Journal ID: ISSN 0952-4746
- Publisher:
- IOP Publishing
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; technetium; biokinetics; radionuclide; nuclear; waste; medicine
Citation Formats
Leggett, Richard Wayne, and Giussani, Augusto. A biokinetic model for systemic technetium in adult humans. United States: N. p., 2015.
Web. doi:10.1088/0952-4746/35/2/297.
Leggett, Richard Wayne, & Giussani, Augusto. A biokinetic model for systemic technetium in adult humans. United States. https://doi.org/10.1088/0952-4746/35/2/297
Leggett, Richard Wayne, and Giussani, Augusto. Fri .
"A biokinetic model for systemic technetium in adult humans". United States. https://doi.org/10.1088/0952-4746/35/2/297. https://www.osti.gov/servlets/purl/1213986.
@article{osti_1213986,
title = {A biokinetic model for systemic technetium in adult humans},
author = {Leggett, Richard Wayne and Giussani, Augusto},
abstractNote = {The International Commission on Radiological Protection (ICRP) currently is updating its biokinetic and dosimetric models for internally deposited radionuclides. Technetium (Tc), the lightest element that exists only in radioactive form, has two important isotopes from the standpoint of potential risk to humans: the long-lived isotope 99Tm(T1/2=2.1x105 y) is present in high concentration in nuclear waste, and the short-lived isotope 99mTc (T1/2=6.02 h) is the most commonly used radionuclide in diagnostic nuclear medicine. This paper reviews data on the biological behavior of technetium and proposes a biokinetic model for systemic technetium in the adult human body for use in radiation protection. Compared with the ICRP s current occupational model for systemic technetium, the proposed model provides a more realistic description of the paths of movement of technetium in the body; provides greater consistency with experimental and medical data; and, for most radiosensitive organs, yields substantially different estimates of cumulative activity (total radioactive decays within the organ) following uptake of 99Tm or 99mTc to blood.},
doi = {10.1088/0952-4746/35/2/297},
journal = {Journal of Radiological Protection},
number = 2,
volume = 35,
place = {United States},
year = {Fri Apr 10 00:00:00 EDT 2015},
month = {Fri Apr 10 00:00:00 EDT 2015}
}
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Dose-response relationships between internally-deposited uranium and select health outcomes in gaseous diffusion plant workers, 1948-2011
journal, May 2018
- Yiin, James H.; Anderson, Jeri L.; Bertke, Stephen J.
- American Journal of Industrial Medicine, Vol. 61, Issue 7
IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms
journal, November 2017
- Andersson, Martin; Johansson, Lennart; Eckerman, Keith
- EJNMMI Research, Vol. 7, Issue 1