Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine
Abstract
In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.
- Authors:
-
- Osaka Univ., Osaka (Japan)
- Basel Univ., Basel (Switzerland); Basel Univ. Hospital, Basel (Switzerland)
- Basel Univ. Hospital, Basel (Switzerland)
- Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland)
- Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland); Univ. of Chicago, Chicago, IL (United States); Argonne National Lab., Argonne, IL (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1225190
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Bioengineering and Biotechnology
- Additional Journal Information:
- Journal Volume: 3; Journal Issue: 3; Journal ID: ISSN 2296-4185
- Publisher:
- Frontiers Research Foundation
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; angiogenesis; growth factors; extracellular matrix; fibrin; protein engineering
Citation Formats
Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., and Banfi, Andrea. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. United States: N. p., 2015.
Web. doi:10.3389/fbioe.2015.00045.
Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., & Banfi, Andrea. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. United States. https://doi.org/10.3389/fbioe.2015.00045
Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., and Banfi, Andrea. Wed .
"Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine". United States. https://doi.org/10.3389/fbioe.2015.00045. https://www.osti.gov/servlets/purl/1225190.
@article{osti_1225190,
title = {Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine},
author = {Martino, Mikael M. and Brkic, Sime and Bovo, Emmanuela and Burger, Maximilian and Schaefer, Dirk J. and Wolff, Thomas and Gurke, Lorenz and Briquez, Priscilla S. and Larsson, Hans M. and Gianni-Barrera, Roberto and Hubbell, Jeffrey A. and Banfi, Andrea},
abstractNote = {In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.},
doi = {10.3389/fbioe.2015.00045},
journal = {Frontiers in Bioengineering and Biotechnology},
number = 3,
volume = 3,
place = {United States},
year = {Wed Apr 01 00:00:00 EDT 2015},
month = {Wed Apr 01 00:00:00 EDT 2015}
}
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VEGF gene therapy: stimulating angiogenesis or angioma-genesis?
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The well-tempered vessel
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Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
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VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond
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Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor
journal, January 2000
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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
journal, January 2007
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Integrin regulation of growth factor receptors
journal, April 2002
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The shunt problem: control of functional shunting in normal and tumour vasculature
journal, July 2010
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Therapeutic angiogenesis for critical limb ischaemia
journal, May 2013
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Vitronectin: Growth Factor Complexes Hold Potential as a Wound Therapy Approach
journal, June 2008
- Upton, Zee; Cuttle, Leila; Noble, Anthony
- Journal of Investigative Dermatology, Vol. 128, Issue 6
Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors
journal, December 2009
- Borselli, Cristina; Storrie, Hannah; Benesch-Lee, Frank
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 8
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix
journal, March 2013
- Martino, M. M.; Briquez, P. S.; Ranga, A.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 12
Induction of Aberrant Vascular Growth, But Not of Normal Angiogenesis, by Cell-Based Expression of Different Doses of Human and Mouse VEGF Is Species-Dependent
journal, February 2013
- Mujagic, Edin; Gianni-Barrera, Roberto; Trani, Marianna
- Human Gene Therapy Methods, Vol. 24, Issue 1
Strategic Directions in Tissue Engineering
journal, December 2007
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