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Title: Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.

Abstract

Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.

Authors:
; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
European Research Council (ERC); University Hospital of Basel; Swiss National Science Foundation (SNSF); USDOE Office of Science - Office of Basic Energy Sciences - Materials Sciences and Engineering Division
OSTI Identifier:
1238795
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article
Journal Name:
Frontiers in Bioengineering and Biotechnology
Additional Journal Information:
Journal Volume: 4; Journal ID: ISSN 2296-4185
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English

Citation Formats

Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., and Banfi, Andrea. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.. United States: N. p., 2015. Web. doi:10.3389/fbioe.2015.00045.
Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., & Banfi, Andrea. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.. United States. doi:10.3389/fbioe.2015.00045.
Martino, Mikael M., Brkic, Sime, Bovo, Emmanuela, Burger, Maximilian, Schaefer, Dirk J., Wolff, Thomas, Gurke, Lorenz, Briquez, Priscilla S., Larsson, Hans M., Gianni-Barrera, Roberto, Hubbell, Jeffrey A., and Banfi, Andrea. Wed . "Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.". United States. doi:10.3389/fbioe.2015.00045.
@article{osti_1238795,
title = {Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.},
author = {Martino, Mikael M. and Brkic, Sime and Bovo, Emmanuela and Burger, Maximilian and Schaefer, Dirk J. and Wolff, Thomas and Gurke, Lorenz and Briquez, Priscilla S. and Larsson, Hans M. and Gianni-Barrera, Roberto and Hubbell, Jeffrey A. and Banfi, Andrea},
abstractNote = {Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.},
doi = {10.3389/fbioe.2015.00045},
journal = {Frontiers in Bioengineering and Biotechnology},
issn = {2296-4185},
number = ,
volume = 4,
place = {United States},
year = {2015},
month = {4}
}

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