Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces
Abstract
The ability to control and manipulate semiconductor/bio interfaces is essential to enable biological nanofabrication pathways and bioelectronic devices. Traditional surface functionalization methods, such as self-assembled monolayers (SAMs), provide limited customization for these interfaces. Polymer brushes offer a wider range of chemistries, but choices that maintain compatibility with both lithographic patterning and biological systems are scarce. Here, we developed a class of bioinspired, sequence-defined polymers, i.e., polypeptoids, as tailored polymer brushes for surface modification of semiconductor substrates. Polypeptoids featuring a terminal hydroxyl (–OH) group are designed and synthesized for efficient melt grafting onto the native oxide layer of Si substrates, forming ultrathin (~1 nm) monolayers. By programming monomer chemistry, our polypeptoid brush platform offers versatile surface modification, including adjustments to surface energy, passivation, preferential biomolecule attachment, and specific biomolecule binding. Importantly, the polypeptoid brush monolayers remain compatible with electron-beam lithographic patterning and retain their chemical characteristics even under harsh lithographic conditions. Electron-beam lithography is used over polypeptoid brushes to generate highly precise, binary nanoscale patterns with localized functionality for the selective immobilization (or passivation) of biomacromolecules, such as DNA origami or streptavidin, onto addressable arrays. This surface modification strategy with bioinspired, sequence-defined polypeptoid brushes enables monomer-level control over surface properties withmore »
- Authors:
-
[1];
[1];
[2];
[1];
[1];
[4];
[1];
[1]
- The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
- The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Prizker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States
- Molecular Vista Inc., San Jose, California 95119, United States
- Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, California 94709, United States
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 2315050
- Alternate Identifier(s):
- OSTI ID: 2323240
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Published Article
- Journal Name:
- ACS Nano
- Additional Journal Information:
- Journal Name: ACS Nano Journal Volume: 18 Journal Issue: 10; Journal ID: ISSN 1936-0851
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; nanopatterned polymer brushes; sequence-defined polymers; semiconductor/bio interfaces; surface modification; selective immobilization of biomolecules
Citation Formats
Yu, Beihang, Chang, Boyce S., Loo, Whitney S., Dhuey, Scott, O’Reilly, Padraic, Ashby, Paul D., Connolly, Michael D., Tikhomirov, Grigory, Zuckermann, Ronald N., and Ruiz, Ricardo. Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces. United States: N. p., 2024.
Web. doi:10.1021/acsnano.3c10204.
Yu, Beihang, Chang, Boyce S., Loo, Whitney S., Dhuey, Scott, O’Reilly, Padraic, Ashby, Paul D., Connolly, Michael D., Tikhomirov, Grigory, Zuckermann, Ronald N., & Ruiz, Ricardo. Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces. United States. https://doi.org/10.1021/acsnano.3c10204
Yu, Beihang, Chang, Boyce S., Loo, Whitney S., Dhuey, Scott, O’Reilly, Padraic, Ashby, Paul D., Connolly, Michael D., Tikhomirov, Grigory, Zuckermann, Ronald N., and Ruiz, Ricardo. Tue .
"Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces". United States. https://doi.org/10.1021/acsnano.3c10204.
@article{osti_2315050,
title = {Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces},
author = {Yu, Beihang and Chang, Boyce S. and Loo, Whitney S. and Dhuey, Scott and O’Reilly, Padraic and Ashby, Paul D. and Connolly, Michael D. and Tikhomirov, Grigory and Zuckermann, Ronald N. and Ruiz, Ricardo},
abstractNote = {The ability to control and manipulate semiconductor/bio interfaces is essential to enable biological nanofabrication pathways and bioelectronic devices. Traditional surface functionalization methods, such as self-assembled monolayers (SAMs), provide limited customization for these interfaces. Polymer brushes offer a wider range of chemistries, but choices that maintain compatibility with both lithographic patterning and biological systems are scarce. Here, we developed a class of bioinspired, sequence-defined polymers, i.e., polypeptoids, as tailored polymer brushes for surface modification of semiconductor substrates. Polypeptoids featuring a terminal hydroxyl (–OH) group are designed and synthesized for efficient melt grafting onto the native oxide layer of Si substrates, forming ultrathin (~1 nm) monolayers. By programming monomer chemistry, our polypeptoid brush platform offers versatile surface modification, including adjustments to surface energy, passivation, preferential biomolecule attachment, and specific biomolecule binding. Importantly, the polypeptoid brush monolayers remain compatible with electron-beam lithographic patterning and retain their chemical characteristics even under harsh lithographic conditions. Electron-beam lithography is used over polypeptoid brushes to generate highly precise, binary nanoscale patterns with localized functionality for the selective immobilization (or passivation) of biomacromolecules, such as DNA origami or streptavidin, onto addressable arrays. This surface modification strategy with bioinspired, sequence-defined polypeptoid brushes enables monomer-level control over surface properties with a large parameter space of monomer chemistry and sequence and therefore is a highly versatile platform to precisely engineer semiconductor/bio interfaces for bioelectronics applications.},
doi = {10.1021/acsnano.3c10204},
journal = {ACS Nano},
number = 10,
volume = 18,
place = {United States},
year = {Tue Feb 27 00:00:00 EST 2024},
month = {Tue Feb 27 00:00:00 EST 2024}
}
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acsnano.3c10204
https://doi.org/10.1021/acsnano.3c10204
Other availability
Search WorldCat to find libraries that may hold this journal
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Fabrication of Lithographically Defined Chemically Patterned Polymer Brushes and Mats
journal, April 2011
- Liu, Chi-Chun; Han, Eungnak; Onses, M. Serdar
- Macromolecules, Vol. 44, Issue 7
Polymer brushes: surface-immobilized macromolecules
journal, June 2000
- Zhao, B.; Brittain, W. J.
- Progress in Polymer Science, Vol. 25, Issue 5
Self-Assembled Monolayers and Polymer Brushes in Biotechnology: Current Applications and Future Perspectives
journal, September 2005
- Senaratne, Wageesha; Andruzzi, Luisa; Ober, Christopher K.
- Biomacromolecules, Vol. 6, Issue 5
New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling
journal, February 2021
- Zhang, Wei; Yang, Yang; Cui, Bianxiao
- Current Opinion in Solid State and Materials Science, Vol. 25, Issue 1
Single-molecule mechanical fingerprinting with DNA nanoswitch calipers
journal, October 2021
- Shrestha, Prakash; Yang, Darren; Tomov, Toma E.
- Nature Nanotechnology, Vol. 16, Issue 12
Patterning self-assembled monolayers
journal, June 2004
- Smith, Rachel K.; Lewis, Penelope A.; Weiss, Paul S.
- Progress in Surface Science, Vol. 75, Issue 1-2
Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers
journal, November 1994
- Miller, Susan M.; Simon, Reyna J.; Ng, Simon
- Bioorganic & Medicinal Chemistry Letters, Vol. 4, Issue 22
Surface chemical reactions on self-assembled silane based monolayers
journal, January 2021
- Wang, Limin; Schubert, Ulrich S.; Hoeppener, Stephanie
- Chemical Society Reviews, Vol. 50, Issue 11
Comparison of the proteolytic susceptibilities of homologous L-amino acid, D-amino acid, and N-substituted glycine peptide and peptoid oligomers
journal, May 1995
- Miller, Susan M.; Simon, Reyna J.; Ng, Simon
- Drug Development Research, Vol. 35, Issue 1
A Reinterpretation of Organic Liquid-Polytetrafluoroethylene Surface Interactions
journal, January 1970
- Kaelble, D. H.; Uy, K. C.
- The Journal of Adhesion, Vol. 2, Issue 1
Controlling Polymer-Surface Interactions with Random Copolymer Brushes
journal, March 1997
- Mansky, P.; Liu, Y.; Huang, E.
- Science, Vol. 275, Issue 5305, p. 1458-1460
Formation and Properties of Anchored Polymers with a Gradual Variation of Grafting Densities on Flat Substrates
journal, April 2003
- Wu, Tao; Efimenko, Kirill; Vlček, Petr
- Macromolecules, Vol. 36, Issue 7
Crystallization in Sequence-Defined Peptoid Diblock Copolymers Induced by Microphase Separation
journal, January 2014
- Sun, Jing; Teran, Alexander A.; Liao, Xunxun
- Journal of the American Chemical Society, Vol. 136, Issue 5
Placement and orientation of individual DNA shapes on lithographically patterned surfaces
journal, August 2009
- Kershner, Ryan J.; Bozano, Luisa D.; Micheel, Christine M.
- Nature Nanotechnology, Vol. 4, Issue 9
Dispersion-Polar Surface Tension Properties of Organic Solids
journal, April 1970
- Kaelble, D. H.
- The Journal of Adhesion, Vol. 2, Issue 2
Patterning Self-Assembled Monolayers: Applications in Materials Science
journal, May 1994
- Kumar, Amit; Biebuyck, Hans A.; Whitesides, George M.
- Langmuir, Vol. 10, Issue 5, p. 1498-1511
Nanoscale chemical imaging by photoinduced force microscopy
journal, March 2016
- Nowak, Derek; Morrison, William; Wickramasinghe, H. Kumar
- Science Advances, Vol. 2, Issue 3
Diels-Alder “Clickable” Polymer Brushes: A Versatile Catalyst-Free Conjugation Platform
journal, March 2017
- Yuksekdag, Yasemin Nursel; Gevrek, Tugce Nihal; Sanyal, Amitav
- ACS Macro Letters, Vol. 6, Issue 4
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
journal, May 2014
- Dalby, Matthew J.; Gadegaard, Nikolaj; Oreffo, Richard O. C.
- Nature Materials, Vol. 13, Issue 6
Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”
journal, January 2022
- Wang, Yu-Min; Kálosi, Anna; Halahovets, Yuriy
- Polymer Chemistry, Vol. 13, Issue 25
Observation of nanoscale opto-mechanical molecular damping as the origin of spectroscopic contrast in photo induced force microscopy
journal, November 2020
- Almajhadi, Mohammad A.; Uddin, Syed Mohammad Ashab; Wickramasinghe, H. Kumar
- Nature Communications, Vol. 11, Issue 1
Simple Coupling Chemistry Linking Carboxyl-Containing Organic Molecules to Silicon Oxide Surfaces under Acidic Conditions
journal, September 2010
- Schmidt, Sebastian W.; Christ, Timo; Glockner, Christian
- Langmuir, Vol. 26, Issue 19
Patterned polymer brushes
journal, January 2012
- Chen, Tao; Amin, Ihsan; Jordan, Rainer
- Chemical Society Reviews, Vol. 41, Issue 8
Density Multiplication and Improved Lithography by Directed Block Copolymer Assembly
journal, August 2008
- Ruiz, R.; Kang, H.; Detcheverry, F. A.
- Science, Vol. 321, Issue 5891
Tunable Hydrophilic or Amphiphilic Coatings: A “Reactive Layer Stack” Approach
journal, January 2015
- Frenzel, Ralf; Höhne, Susanne; Hanzelmann, Christian
- ACS Applied Materials & Interfaces, Vol. 7, Issue 23
Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations
journal, January 2003
- Levene, M. J.
- Science, Vol. 299, Issue 5607
Sequential Brush Grafting for Chemically and Dimensionally Tolerant Directed Self-Assembly of Block Copolymers
journal, December 2022
- Chang, Boyce S.; Loo, Whitney S.; Yu, Beihang
- ACS Applied Materials & Interfaces, Vol. 15, Issue 1
Control of Crystallization and Melting Behavior in Sequence Specific Polypeptoids
journal, July 2010
- Rosales, Adrianne M.; Murnen, Hannah K.; Zuckermann, Ronald N.
- Macromolecules, Vol. 43, Issue 13
Tunable Phase Behavior of Polystyrene–Polypeptoid Block Copolymers
journal, July 2012
- Rosales, Adrianne M.; McCulloch, Bryan L.; Zuckermann, Ronald N.
- Macromolecules, Vol. 45, Issue 15
Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device
journal, October 2022
- Reed, Brian D.; Meyer, Michael J.; Abramzon, Valentin
- Science, Vol. 378, Issue 6616
Inorganic semiconductor biointerfaces
journal, November 2018
- Jiang, Yuanwen; Tian, Bozhi
- Nature Reviews Materials, Vol. 3, Issue 12
Thermal Properties of Aliphatic Polypeptoids
journal, January 2013
- Fetsch, Corinna; Luxenhofer, Robert
- Polymers, Vol. 5, Issue 1
Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives
journal, August 2010
- Culf, Adrian S.; Ouellette, Rodney J.
- Molecules, Vol. 15, Issue 8
Selective aluminum passivation for targeted immobilization of single DNA polymerase molecules in zero-mode waveguide nanostructures
journal, January 2008
- Korlach, J.; Marks, P. J.; Cicero, R. L.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 4
Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level
journal, March 2011
- Schvartzman, Mark; Palma, Matteo; Sable, Julia
- Nano Letters, Vol. 11, Issue 3
Self-assembled monolayers in organic electronics
journal, January 2017
- Casalini, Stefano; Bortolotti, Carlo Augusto; Leonardi, Francesca
- Chemical Society Reviews, Vol. 46, Issue 1
Absolute and arbitrary orientation of single-molecule shapes
journal, February 2021
- Gopinath, Ashwin; Thachuk, Chris; Mitskovets, Anya
- Science, Vol. 371, Issue 6531
Optimized design of block copolymers with covarying properties for nanolithography
journal, November 2022
- Feng, Hongbo; Dolejsi, Moshe; Zhu, Ning
- Nature Materials, Vol. 21, Issue 12
Brush Layers of Bioinspired Polypeptoids for Deterministic Doping of Semiconductors
journal, November 2022
- Ospina, Viviana Maria; Chiarcos, Riccardo; Antonioli, Diego
- ACS Applied Electronic Materials, Vol. 4, Issue 12
Morphology of Nanostructured Polymer Brushes Dependent on Production and Treatment
journal, June 2017
- Chen, Wei-Liang; Menzel, Matthias; Prucker, Oswald
- Macromolecules, Vol. 50, Issue 12
Observing the Mushroom-to-Brush Transition for Kinesin Proteins
journal, November 2013
- Dumont, Emmanuel L. P.; Belmas, Herve; Hess, Henry
- Langmuir, Vol. 29, Issue 49
Insensitivity of Sterically Defined Helical Chain Conformations to Solvent Quality in Dilute Solution
journal, May 2020
- Yu, Beihang; Danielsen, Scott P. O.; Yang, Kai-Chieh
- ACS Macro Letters, Vol. 9, Issue 6
Glass Transition Behavior in Ultra-Thin Polystyrene Films
journal, January 1995
- Keddie, J. L.; Jones, R. A. L.
- Israel Journal of Chemistry, Vol. 35, Issue 1
Patterning Ligands on Reactive SAMs by Microcontact Printing
journal, February 1999
- Lahiri, Joydeep; Ostuni, Emanuele; Whitesides, George M.
- Langmuir, Vol. 15, Issue 6
Surface-Initiated Controlled Radical Polymerization: State-of-the-Art, Opportunities, and Challenges in Surface and Interface Engineering with Polymer Brushes
journal, January 2017
- Zoppe, Justin O.; Ataman, Nariye Cavusoglu; Mocny, Piotr
- Chemical Reviews, Vol. 117, Issue 3
From Self-Assembled Monolayers to Coatings: Advances in the Synthesis and Nanobio Applications of Polymer Brushes
journal, July 2015
- Kim, Myungwoong; Schmitt, Samantha; Choi, Jonathan
- Polymers, Vol. 7, Issue 7
Self-Registered Self-Assembly of Block Copolymers
journal, July 2017
- Wan, Lei; Ruiz, Ricardo; Gao, He
- ACS Nano, Vol. 11, Issue 8
Patterned Biofunctional Poly(acrylic acid) Brushes on Silicon Surfaces
journal, September 2007
- Dong, Rong; Krishnan, Sitaraman; Baird, Barbara A.
- Biomacromolecules, Vol. 8, Issue 10
Protein nanoarray on Prolinker™ surface constructed by atomic force microscopy dip-pen nanolithography for analysis of protein interaction
journal, February 2006
- Lee, Minsu; Kang, Dong-Ku; Yang, Hyun-Kyu
- PROTEOMICS, Vol. 6, Issue 4
Roadmap on biological pathways for electronic nanofabrication and materials
journal, January 2019
- Bathe, Mark; Chrisey, Linda A.; Herr, Daniel J. C.
- Nano Futures, Vol. 3, Issue 1
Protein Nanoarrays Generated By Dip-Pen Nanolithography
journal, February 2002
- Lee, K. -B.
- Science, Vol. 295, Issue 5560
Manipulation of Surface Properties by Patterning of Covalently Bound Polymer Brushes
journal, March 2000
- Husemann, Marc; Morrison, Michael; Benoit, Didier
- Journal of the American Chemical Society, Vol. 122, Issue 8
Bench-Top Fabrication of Single-Molecule Nanoarrays by DNA Origami Placement
journal, July 2021
- Shetty, Rishabh M.; Brady, Sarah R.; Rothemund, Paul W. K.
- ACS Nano, Vol. 15, Issue 7
Determination of the persistence length of helical and non-helical polypeptoids in solution
journal, January 2012
- Rosales, Adrianne M.; Murnen, Hannah K.; Kline, Steven R.
- Soft Matter, Vol. 8, Issue 13
Nanoscale spectroscopic origins of photoinduced tip–sample force in the midinfrared
journal, December 2019
- Jahng, Junghoon; Potma, Eric O.; Lee, Eun Seong
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 52
Estimation of the surface free energy of polymers
journal, August 1969
- Owens, D. K.; Wendt, R. C.
- Journal of Applied Polymer Science, Vol. 13, Issue 8
The surface chemistry of amorphous silica. Zhuravlev model
journal, November 2000
- Zhuravlev, L. T.
- Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 173, Issue 1-3
New Peptidomimetic Polymers for Antifouling Surfaces
journal, June 2005
- Statz, Andrea R.; Meagher, Robert J.; Barron, Annelise E.
- Journal of the American Chemical Society, Vol. 127, Issue 22
Roadmap on semiconductor–cell biointerfaces
journal, March 2018
- Tian, Bozhi; Xu, Shuai; Rogers, John A.
- Physical Biology, Vol. 15, Issue 3
Monomer Sequence Effects on Interfacial Width and Mixing in Self-Assembled Diblock Copolymers
journal, April 2020
- Patterson, Anastasia L.; Yu, Beihang; Danielsen, Scott P. O.
- Macromolecules, Vol. 53, Issue 9
Chemical Patterns for Directed Self-Assembly of Lamellae-Forming Block Copolymers with Density Multiplication of Features
journal, February 2013
- Liu, Chi-Chun; Ramírez-Hernández, Abelardo; Han, Eungnak
- Macromolecules, Vol. 46, Issue 4
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
journal, December 1992
- Zuckermann, Ronald N.; Kerr, Janice M.; Kent, Stephen B. H.
- Journal of the American Chemical Society, Vol. 114, Issue 26
Protein, cell and bacterial fouling resistance of polypeptoid-modified surfaces: effect of side-chain chemistry
journal, January 2008
- Statz, Andrea R.; Barron, Annelise E.; Messersmith, Phillip B.
- Soft Matter, Vol. 4, Issue 1
Preparation of Poly(acrylic acid) Nano‐films by In‐situ Polymerization of Acrylic Acid Macroclusters on Silicon Oxide Surfaces
journal, August 2008
- Zhang, Li; Mizukami, Masashi; Kurihara, Kazue
- Macromolecular Symposia, Vol. 270, Issue 1
Molecular-scale spatio-chemical control of the activating-inhibitory signal integration in NK cells
journal, June 2021
- Toledo, Esti; Le Saux, Guillaume; Edri, Avishay
- Science Advances, Vol. 7, Issue 24
Optimized Assembly and Covalent Coupling of Single-Molecule DNA Origami Nanoarrays
journal, November 2014
- Gopinath, Ashwin; Rothemund, Paul W. K.
- ACS Nano, Vol. 8, Issue 12
Sequence of Hydrophobic and Hydrophilic Residues in Amphiphilic Polymer Coatings Affects Surface Structure and Marine Antifouling/Fouling Release Properties
journal, March 2014
- van Zoelen, Wendy; Buss, Hilda G.; Ellebracht, Nathan C.
- ACS Macro Letters, Vol. 3, Issue 4
Hydrogen-bonded surface macroclusters of carboxlic acid on silica in cyclohexane
journal, January 2001
- Kurihara, Kazue; Mizukami, Masashi
- Proceedings of the Japan Academy, Series B, Vol. 77, Issue 6
Alkoxylation Reaction of Alcohol on Silica Surfaces Studied by Sum Frequency Vibrational Spectroscopy
journal, April 2021
- Luo, Ting; Zhang, Ruidan; Zeng, Wei-Wang
- The Journal of Physical Chemistry C, Vol. 125, Issue 16
Configuration of grafted polystyrene chains in the melt: Temperature and concentration dependence
journal, August 1992
- Zhao, X.; Zhao, W.; Zheng, X.
- Physical Review Letters, Vol. 69, Issue 5
Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements
journal, October 2022
- Bueno-Alejo, Carlos J.; Santana Vega, Marina; Chaplin, Amanda K.
- ACS Applied Materials & Interfaces, Vol. 14, Issue 44
50th Anniversary Perspective : Polymer Brushes: Novel Surfaces for Future Materials
journal, May 2017
- Chen, Wei-Liang; Cordero, Roselynn; Tran, Hai
- Macromolecules, Vol. 50, Issue 11
Surface-Assisted Large-Scale Ordering of DNA Origami Tiles
journal, June 2014
- Aghebat Rafat, Ali; Pirzer, Tobias; Scheible, Max B.
- Angewandte Chemie International Edition, Vol. 53, Issue 29
A structural definition of polymer brushes
journal, January 2007
- Brittain, William J.; Minko, Sergiy
- Journal of Polymer Science Part A: Polymer Chemistry, Vol. 45, Issue 16
Evidence of Mechanochemical Control in “Grafting to” Reactions of Hydroxy-Terminated Statistical Copolymers
journal, December 2020
- Laus, Michele; Chiarcos, Riccardo; Gianotti, Valentina
- Macromolecules, Vol. 54, Issue 1
Antifouling Glycocalyx-Mimetic Peptoids
journal, August 2013
- Ham, Hyun Ok; Park, Sung Hyun; Kurutz, Josh W.
- Journal of the American Chemical Society, Vol. 135, Issue 35
Sequence Programmable Peptoid Polymers for Diverse Materials Applications
journal, April 2015
- Knight, Abigail S.; Zhou, Effie Y.; Francis, Matthew B.
- Advanced Materials, Vol. 27, Issue 38
Protein Adsorption on Poly( N -isopropylacrylamide) Brushes: Dependence on Grafting Density and Chain Collapse
journal, July 2011
- Xue, Changying; Yonet-Tanyeri, Nihan; Brouette, Nicolas
- Langmuir, Vol. 27, Issue 14
Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach
journal, March 2020
- Scheideler, Olivia J.; Yang, Chun; Kozminsky, Molly
- Science Advances, Vol. 6, Issue 12
Future lab-on-a-chip technologies for interrogating individual molecules
journal, July 2006
- Craighead, Harold
- Nature, Vol. 442, Issue 7101
Modification of a polystyrene brush layer by insertion of poly(methyl methacrylate) molecules
journal, January 2009
- Liu, Guoliang; Ji, Shengxiang; Stuen, Karl O.
- Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, Vol. 27, Issue 6
Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure
journal, February 2019
- Gimenez, Diana; Zhou, Guangfeng; Hurley, Matthew F. D.
- Journal of the American Chemical Society, Vol. 141, Issue 8