Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials
Abstract
Abstract Polypeptoids (poly‐N‐substituent glycines) are a class of highly tailorable peptidomimetic polymers. Polypeptoids have identical backbones as polypeptides (poly‐C‐substituent glycines), but sidechains of polypeptoids are appended to backbone nitrogen rather than α‐carbon of polypeptides. As a result, peptoid backbone lacks of chirality and hydrogen bond donors. This unique structure gives polypeptoids a combined merit of both high stability as synthetic polymers and biocompatibility as biopolymers. In addition, peptoid sequences can be engineered precisely to assemble specific crystalline patterns such as spheres, fibers, ribbons, tubes, and sheets, which shows promising potentials of polypeptoids for different applications such as antimicrobials, catalysts, drug delivery, and templating inorganic materials. In this review, we summarize recent investigations into hierarchical self‐assembly pathways and molecular structures of peptoid crystals that are of interest as templates for fabricating functional materials for potential biomedical, biochemical, and bioengineering applications. This review provides a summary of recent experimental and computational studies of polypeptoid assembly in solution and solid‐liquid interfaces, current achievements in the field, and discusses future challenges and opportunities for the rational design of self‐assembled polypeptoid nanomaterials.
- Publication Date:
- Research Org.:
- Univ. of Washington, Seattle, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1823072
- Alternate Identifier(s):
- OSTI ID: 1814039
- Grant/Contract Number:
- SC0019288; DE‐SC0019288
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biopolymers
- Additional Journal Information:
- Journal Volume: 112; Journal Issue: 9; Journal ID: ISSN 0006-3525
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Zhao, Mingfei. Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials. United States: N. p., 2021.
Web. doi:10.1002/bip.23469.
Zhao, Mingfei. Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials. United States. https://doi.org/10.1002/bip.23469
Zhao, Mingfei. Wed .
"Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials". United States. https://doi.org/10.1002/bip.23469. https://www.osti.gov/servlets/purl/1823072.
@article{osti_1823072,
title = {Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials},
author = {Zhao, Mingfei},
abstractNote = {Abstract Polypeptoids (poly‐N‐substituent glycines) are a class of highly tailorable peptidomimetic polymers. Polypeptoids have identical backbones as polypeptides (poly‐C‐substituent glycines), but sidechains of polypeptoids are appended to backbone nitrogen rather than α‐carbon of polypeptides. As a result, peptoid backbone lacks of chirality and hydrogen bond donors. This unique structure gives polypeptoids a combined merit of both high stability as synthetic polymers and biocompatibility as biopolymers. In addition, peptoid sequences can be engineered precisely to assemble specific crystalline patterns such as spheres, fibers, ribbons, tubes, and sheets, which shows promising potentials of polypeptoids for different applications such as antimicrobials, catalysts, drug delivery, and templating inorganic materials. In this review, we summarize recent investigations into hierarchical self‐assembly pathways and molecular structures of peptoid crystals that are of interest as templates for fabricating functional materials for potential biomedical, biochemical, and bioengineering applications. This review provides a summary of recent experimental and computational studies of polypeptoid assembly in solution and solid‐liquid interfaces, current achievements in the field, and discusses future challenges and opportunities for the rational design of self‐assembled polypeptoid nanomaterials.},
doi = {10.1002/bip.23469},
journal = {Biopolymers},
number = 9,
volume = 112,
place = {United States},
year = {Wed Aug 18 00:00:00 EDT 2021},
month = {Wed Aug 18 00:00:00 EDT 2021}
}
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