Development of Antimicrobial PLA Composites for Fused Filament Fabrication
Abstract
In addition to possessing the desirable properties of being a biodegradable and biocompatible polymer fabricated from renewable resources, poly (lactic acid) (PLA) has useful mechanical and thermal attributes that has enabled it to be one of the most widely-used plastics for medicine, manufacturing, and agriculture. Yet, PLA composites have not been heavily explored for use in 3D-printing applications, and the range of feasible materials for the technology is limited, which inhibits its potential growth and industry adoption. In this study, tunable, multifunctional antimicrobial PLA composite filaments for 3D-printing have been fabricated and tested via chemical, thermal, mechanical, and antimicrobial experiments. Thermally stable antimicrobial ceramics, ZnO and TiO2, were used as fillers up to 30 wt%, and poly (ethylene glycol) (PEG) was used as a plasticizer to tune the physical material properties. Results demonstrate that the PLA composite filaments exhibit the thermal phase behaviors and thermal stability suitable for 3D-printing. Additionally, PEG can be used to tune the mechanical properties while not affecting the antimicrobial efficacy that ZnO and TiO2 imbue.
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1766341
- Alternate Identifier(s):
- OSTI ID: 1804372
- Report Number(s):
- LA-UR-21-20929
Journal ID: ISSN 2073-4360; POLYCK; PII: polym13040580
- Grant/Contract Number:
- US Department of Energy’s National Nuclear Security Administration contract DE-AC52-06NA25396; 89233218CNA000001; AC52-06NA25396
- Resource Type:
- Published Article
- Journal Name:
- Polymers
- Additional Journal Information:
- Journal Name: Polymers Journal Volume: 13 Journal Issue: 4; Journal ID: ISSN 2073-4360
- Publisher:
- MDPI AG
- Country of Publication:
- Switzerland
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; fused filament fabrication; FFF; additive manufacturing; AM; 3D-printing; PLA; ZnO; TiO2; polymer composites; PEG
Citation Formats
Brounstein, Zachary, Yeager, Chris M., and Labouriau, Andrea. Development of Antimicrobial PLA Composites for Fused Filament Fabrication. Switzerland: N. p., 2021.
Web. doi:10.3390/polym13040580.
Brounstein, Zachary, Yeager, Chris M., & Labouriau, Andrea. Development of Antimicrobial PLA Composites for Fused Filament Fabrication. Switzerland. https://doi.org/10.3390/polym13040580
Brounstein, Zachary, Yeager, Chris M., and Labouriau, Andrea. Mon .
"Development of Antimicrobial PLA Composites for Fused Filament Fabrication". Switzerland. https://doi.org/10.3390/polym13040580.
@article{osti_1766341,
title = {Development of Antimicrobial PLA Composites for Fused Filament Fabrication},
author = {Brounstein, Zachary and Yeager, Chris M. and Labouriau, Andrea},
abstractNote = {In addition to possessing the desirable properties of being a biodegradable and biocompatible polymer fabricated from renewable resources, poly (lactic acid) (PLA) has useful mechanical and thermal attributes that has enabled it to be one of the most widely-used plastics for medicine, manufacturing, and agriculture. Yet, PLA composites have not been heavily explored for use in 3D-printing applications, and the range of feasible materials for the technology is limited, which inhibits its potential growth and industry adoption. In this study, tunable, multifunctional antimicrobial PLA composite filaments for 3D-printing have been fabricated and tested via chemical, thermal, mechanical, and antimicrobial experiments. Thermally stable antimicrobial ceramics, ZnO and TiO2, were used as fillers up to 30 wt%, and poly (ethylene glycol) (PEG) was used as a plasticizer to tune the physical material properties. Results demonstrate that the PLA composite filaments exhibit the thermal phase behaviors and thermal stability suitable for 3D-printing. Additionally, PEG can be used to tune the mechanical properties while not affecting the antimicrobial efficacy that ZnO and TiO2 imbue.},
doi = {10.3390/polym13040580},
journal = {Polymers},
number = 4,
volume = 13,
place = {Switzerland},
year = {Mon Feb 15 00:00:00 EST 2021},
month = {Mon Feb 15 00:00:00 EST 2021}
}
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Works referenced in this record:
Polylactide/exfoliated graphite nanocomposites with enhanced thermal stability, mechanical modulus, and electrical conductivity: PLA/EG Nanocomposites
journal, March 2010
- Kim, Il-Hwan; Jeong, Young Gyu
- Journal of Polymer Science Part B: Polymer Physics, Vol. 48, Issue 8
Thermal Degradation Processes of End-Capped Poly( l -lactide)s in the Presence and Absence of Residual Zinc Catalyst
journal, July 2004
- Abe, Hideki; Takahashi, Naoki; Kim, Kang Ju
- Biomacromolecules, Vol. 5, Issue 4
Antimicrobial additives for poly(lactic acid) materials and their applications: current state and perspectives
journal, July 2018
- Scaffaro, Roberto; Lopresti, Francesco; Marino, Andreana
- Applied Microbiology and Biotechnology, Vol. 102, Issue 18
Physical aging and mechanical performance of poly( l -lactide)/ZnO nanocomposites
journal, March 2016
- Lizundia, Erlantz; Pérez-Álvarez, Leyre; Sáenz-Pérez, Míriam
- Journal of Applied Polymer Science, Vol. 133, Issue 45
Structure and properties of highly toughened biodegradable polylactide/ZnO biocomposite films
journal, March 2014
- Jayaramudu, J.; Das, Kunal; Sonakshi, M.
- International Journal of Biological Macromolecules, Vol. 64
Ternary melt blends of poly(lactic acid)/poly(vinyl alcohol)-chitosan
journal, October 2015
- Grande, Rafael; Pessan, Luiz A.; Carvalho, Antonio J. F.
- Industrial Crops and Products, Vol. 72
Poly(lactic acid) / Poly(ethylene glycol) blends: Mechanical, thermal and morphological properties
conference, January 2016
- Bijarimi, M.; Ahmad, S.; Rasid, R.
- REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION: Proceedings of the 35th Annual Review of Progress in Quantitative Nondestructive Evaluation, AIP Conference Proceedings
Kinetic study on pyrolysis of tobacco residues from the cigarette industry
journal, January 2013
- Gao, Wenhua; Chen, Kefu; Xiang, Zhouyang
- Industrial Crops and Products, Vol. 44
PLA-TiO2 nanocomposites: Thermal, morphological, structural, and humidity sensing properties
journal, October 2018
- Mallick, Shoaib; Ahmad, Zubair; Touati, Farid
- Ceramics International, Vol. 44, Issue 14
Catalytic effect of nanosized ZnO and TiO2 on thermal degradation of poly(lactic acid) and isoconversional kinetic analysis
journal, February 2019
- Wang, Xiao-jie; Huang, Zhen; Wei, Meng-yu
- Thermochimica Acta, Vol. 672
Actinobacteria as Promising Candidate for Polylactic Acid Type Bioplastic Degradation
journal, December 2019
- Butbunchu, Natthicha; Pathom-Aree, Wasu
- Frontiers in Microbiology, Vol. 10
Infrared and Raman studies on polylactide acid and polyethylene glycol-400 blend
conference, January 2016
- Yuniarto, Kurniawan; Purwanto, Yohanes Aris; Purwanto, Setyo
- THE 3RD INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS SCIENCE AND TECHNOLOGY (ICAMST 2015), AIP Conference Proceedings
Ecotoxicity of nanosized TiO2. Review of in vivo data
journal, March 2011
- Menard, Anja; Drobne, Damjana; Jemec, Anita
- Environmental Pollution, Vol. 159, Issue 3
Rapid Manufacturing and Rapid Tooling with Layer Manufacturing (lm) Technologies, State of the art and Future Perspectives
journal, January 2003
- Levy, Gideon N.; Schindel, Ralf; Kruth, J. P.
- CIRP Annals, Vol. 52, Issue 2
Poly (lactic acid) blends: Processing, properties and applications
journal, March 2019
- Nofar, Mohammadreza; Sacligil, Dilara; Carreau, Pierre J.
- International Journal of Biological Macromolecules, Vol. 125
Adsorption of poly(ethylene oxide)–block–polylactide copolymers on polylactide as studied by ATR-FTIR spectroscopy
journal, April 2007
- Popelka, Štěpán; Machová, Lud'ka; Rypáček, František
- Journal of Colloid and Interface Science, Vol. 308, Issue 2
Surface characteristics of PLA and PLGA films
journal, December 2006
- Paragkumar N., Thanki; Edith, Dellacherie; Six, Jean-Luc
- Applied Surface Science, Vol. 253, Issue 5
Morphology, Crystallization and Thermal Behaviors of PLA-Based Composites: Wonderful Effects of Hybrid GO/PEG via Dynamic Impregnating
journal, October 2017
- Jia, Shikui; Yu, Demei; Zhu, Yan
- Polymers, Vol. 9, Issue 12
Tough blends of poly(lactide) and amorphous poly([R,S]-3-hydroxy butyrate) – morphology and properties
journal, November 2013
- Bartczak, Zbigniew; Galeski, Andrzej; Kowalczuk, Marek
- European Polymer Journal, Vol. 49, Issue 11
Preparation and Characterization of Polymer Composite Materials Based on PLA/TiO2 for Antibacterial Packaging
journal, December 2018
- González, Edwin A. Segura; Olmos, Dania; Lorente, Miguel Ángel
- Polymers, Vol. 10, Issue 12
Poly (lactic acid)/titanium dioxide composites: Preparation and performance under ultraviolet irradiation
journal, June 2012
- Man, Changzhen; Zhang, Chunmei; Liu, Yiming
- Polymer Degradation and Stability, Vol. 97, Issue 6
Effect of TiO2 and ZnO on PLA degradation in various media
journal, January 2017
- Marra, Antonella; Cimmino, Sossio; Silvestre, Clara
- Advanced Material Science, Vol. 2, Issue 2
Overview of Poly(lactic acid) (PLA) Fibre: Part I: Production, Properties, Performance, Environmental Impact, and End-use Applications of Poly(lactic acid) Fibres
journal, November 2009
- Avinc, Ozan; Khoddami, Akbar
- Fibre Chemistry, Vol. 41, Issue 6
Effect of partial crosslinking on morphology and properties of the poly(β-hydroxybutyrate)/poly(d,l-lactic acid) blends
journal, September 2013
- Dong, Weifu; Ma, Piming; Wang, Shifeng
- Polymer Degradation and Stability, Vol. 98, Issue 9
Studies of polylactide/zinc oxide nanocomposites: influence of surface treatment on zinc oxide antibacterial activities in textile nanocomposites
journal, January 2015
- Doumbia, Awa Soronfé; Vezin, Hervé; Ferreira, Manuela
- Journal of Applied Polymer Science, Vol. 132, Issue 17
In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity
journal, March 2012
- Buerki-Thurnherr, Tina; Xiao, Lisong; Diener, Liliane
- Nanotoxicology, Vol. 7, Issue 4
PLA Nanocomposites with Functionalized TiO 2 Nanoparticles
journal, February 2013
- Buzarovska, Aleksandra
- Polymer-Plastics Technology and Engineering, Vol. 52, Issue 3
Thermoplastic PVA/PLA Blends with Improved Processability and Hydrophobicity
journal, August 2014
- Li, Hong-Zhen; Chen, Si-Chong; Wang, Yu-Zhong
- Industrial & Engineering Chemistry Research, Vol. 53, Issue 44
In vitro toxicity of zinc oxide nanoparticles: a review
journal, March 2015
- Pandurangan, Muthuraman; Kim, Doo Hwan
- Journal of Nanoparticle Research, Vol. 17, Issue 3
Compatibility confirmation and refinement of thermal and mechanical properties of poly (lactic acid)/poly (ethylene- co -glycidyl methacrylate) blend reinforced by hexagonal boron nitride
journal, August 2017
- Kumar, Ashish; Venkatappa Rao, T.; Ray Chowdhury, S.
- Reactive and Functional Polymers, Vol. 117
Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios
journal, June 2016
- Phan, Quoc Thong; Le, Mai Huong; Le, Thi Thu Huong
- International Journal of Pharmaceutics, Vol. 507, Issue 1-2
Poly(lactic acid) crystallization
journal, December 2012
- Saeidlou, Sajjad; Huneault, Michel A.; Li, Hongbo
- Progress in Polymer Science, Vol. 37, Issue 12
Polymeric Cracking of Waste Polyethylene Terephthalate to Chemicals and Energy
journal, July 2011
- Brems, Anke; Baeyens, Jan; Vandecasteele, Carlo
- Journal of the Air & Waste Management Association, Vol. 61, Issue 7
Investigation of the structure of solution grown crystals of lactide copolymers by means of chemical reactions
journal, November 1973
- Fischer, E. W.; Sterzel, Hans J.; Wegner, G.
- Kolloid-Zeitschrift und Zeitschrift für Polymere, Vol. 251, Issue 11
Nanocomposites of PLA containing ZnO nanofibers made by solvent cast 3D printing: Production and characterization
journal, May 2019
- Nonato, R. C.; Mei, L. H. I.; Bonse, B. C.
- European Polymer Journal, Vol. 114
Thermogravimetric pyrolysis of waste polyethylene-terephthalate and polystyrene: A critical assessment of kinetics modelling
journal, June 2011
- Brems, Anke; Baeyens, Jan; Beerlandt, Johan
- Resources, Conservation and Recycling, Vol. 55, Issue 8
Poly(lactic acid)/Poly(ethylene glycol) Polymer Nanocomposites: Effects of Graphene Nanoplatelets
journal, December 2013
- Chieng, Buong; Ibrahim, Nor; Yunus, Wan
- Polymers, Vol. 6, Issue 1
New approach on the development of plasticized polylactide (PLA): Grafting of poly(ethylene glycol) (PEG) via reactive extrusion
journal, November 2011
- Hassouna, Fatima; Raquez, Jean-Marie; Addiego, Frédéric
- European Polymer Journal, Vol. 47, Issue 11
Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications
journal, July 2017
- Bayer, Ilker
- Materials, Vol. 10, Issue 7
PLA-ZnO nanocomposite films: Water vapor barrier properties and specific end-use characteristics
journal, November 2013
- Pantani, Roberto; Gorrasi, Giuliana; Vigliotta, Giovanni
- European Polymer Journal, Vol. 49, Issue 11
PEG drugs: an overview
journal, July 2001
- Greenwald, R. B.
- Journal of Controlled Release, Vol. 74, Issue 1-3
Kinetic Parameters from Thermogravimetric Data
journal, January 1964
- Coats, A. W.; Redfern, J. P.
- Nature, Vol. 201, Issue 4914
In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres
journal, December 2005
- You, Young; Lee, Sung Won; Youk, Ji Ho
- Polymer Degradation and Stability, Vol. 90, Issue 3
Abiotic and biotic environmental degradation of the bioplastic polymer poly(lactic acid): A review
journal, March 2017
- Karamanlioglu, Mehlika; Preziosi, Richard; Robson, Geoffrey D.
- Polymer Degradation and Stability, Vol. 137
Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints
journal, January 2016
- Thompson, Mary Kathryn; Moroni, Giovanni; Vaneker, Tom
- CIRP Annals, Vol. 65, Issue 2
Toxicity and bioaccumulation of TiO2 nanoparticle aggregates in Daphnia magna
journal, January 2010
- Zhu, Xiaoshan; Chang, Yung; Chen, Yongsheng
- Chemosphere, Vol. 78, Issue 3
Evaluation of reliability of Coats-Redfern method for kinetic analysis of non-isothermal TGA
journal, February 2008
- Ebrahimi-Kahrizsangi, R.; Abbasi, M. H.
- Transactions of Nonferrous Metals Society of China, Vol. 18, Issue 1
Influence of ZnO nanoparticle filler on the properties and wear resistance of polycarbonate
journal, May 2007
- Carrión, F. J.; Sanes, J.; Bermúdez, Maria-Dolores
- Wear, Vol. 262, Issue 11-12
Fused filament fabrication of polymer composites for extreme environments
journal, June 2020
- Brounstein, Zachary; Talley, Samantha; Dumont, Joseph H.
- Journal of Materials Research, Vol. 35, Issue 12
Synthesis, optimization and applications of ZnO/polymer nanocomposites
journal, May 2019
- Ponnamma, Deepalekshmi; Cabibihan, John-John; Rajan, Mariappan
- Materials Science and Engineering: C, Vol. 98
Current advances and future perspectives of 3D printing natural-derived biopolymers
journal, March 2019
- Liu, Jun; Sun, Lushan; Xu, Wenyang
- Carbohydrate Polymers, Vol. 207
Current progress in the production of PLA-ZnO nanocomposites: Beneficial effects of chain extender addition on key properties
journal, June 2015
- Murariu, Marius; Paint, Yoann; Murariu, Oltea
- Journal of Applied Polymer Science, Vol. 132, Issue 48
Polylactic acid/zinc oxide biocomposite films for food packaging application
journal, July 2016
- Marra, Antonella; Silvestre, Clara; Duraccio, Donatella
- International Journal of Biological Macromolecules, Vol. 88
Improving the impact strength of Poly(lactic acid) (PLA) in fused layer modeling (FLM)
journal, April 2017
- Wang, Lu; Gramlich, William M.; Gardner, Douglas J.
- Polymer, Vol. 114
Antibacterial PLA/PEG electrospun fibers: Comparative study between grafting and blending PEG
journal, February 2016
- Toncheva, A.; Mincheva, R.; Kancheva, M.
- European Polymer Journal, Vol. 75
Crystallization kinetics and morphology of biodegradable poly(l-lactic acid)/graphene oxide nanocomposites: Influences of graphene oxide loading and crystallization temperature
journal, January 2012
- Wang, Huishan; Qiu, Zhaobin
- Thermochimica Acta, Vol. 527
Biodegradation of Blown Films Based on Poly(lactic acid) under Natural Conditions
journal, November 2008
- Sedlarik, Vladimir; Saha, Nabanita; Sedlarikova, Jana
- Macromolecular Symposia, Vol. 272, Issue 1
Effect of PEG on PLA/PEG blend and its nanocomposites: A study of thermo-mechanical and morphological characterization
journal, September 2013
- Mohapatra, Aswini Kumar; Mohanty, S.; Nayak, S. K.
- Polymer Composites, Vol. 35, Issue 2