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Title: Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression

Abstract

In automobile accidents, abdominal injuries are often life-threatening yet not apparent at the time of initial injury. The liver is the most commonly injured abdominal organ from this type of trauma. In contrast to current safety tests involving crash dummies, a more detailed, efficient approach to predict the risk of human injuries is computational modelling and simulations. Further, the development of accurate computational human models requires knowledge of the mechanical properties of tissues in various stress states, especially in high-impact scenarios. In this study, a polymeric split-Hopkinson pressure bar (PSHPB) was utilized to apply various high strain rates to porcine liver tissue to investigate its material behavior during high strain rate compression. Liver tissues were subjected to high strain rate impacts at 350, 550, 1000, and 1550 s–1. Tissue directional dependency was also explored by PSHPB testing along three orthogonal directions of liver at a strain rate of 350 s–1. Histology of samples from each of the three directions was performed to examine the structural properties of porcine liver. Porcine liver tissue showed an inelastic and strain rate-sensitive response at high strain rates. The liver tissue was found lacking directional dependency, which could be explained by the isotropic microstructure observedmore » after staining and imaging. Furthermore, finite element analysis (FEA) of the PSHPB tests revealed the stress profile inside liver tissue and served as a validation of PSHPB methodology. The present findings can assist in the development of more accurate computational models of liver tissue at high-rate impact conditions allowing for understanding of subfailure and failure mechanisms.« less

Authors:
 [1]; ORCiD logo [1];  [1];  [1];  [1];  [1];  [1];  [2];  [3]
+ Show Author Affiliations
  1. Mississippi State Univ., Mississippi State, MS (United States)
  2. Mississippi State Univ., Mississippi State, MS (United States); Univ. of Texas, Arlington, TX (United States)
  3. Mississippi State Univ., Mississippi State, MS (United States); Univ. of Florida, Gainesville, FL (United States)
Publication Date:
Research Org.:
National Energy Technology Laboratory (NETL), Pittsburgh, PA, Morgantown, WV, and Albany, OR (United States); Mississippi State Univ., Mississippi State, MS (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1629621
Grant/Contract Number:  
FC26-06NT42755
Resource Type:
Accepted Manuscript
Journal Name:
Bioengineering
Additional Journal Information:
Journal Volume: 6; Journal Issue: 2; Journal ID: ISSN 2306-5354
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; soft tissue; liver; high-rate compression; polymeric split-Hopkinson pressure bar; finite element modeling

Citation Formats

Chen, Joseph, Patnaik, Sourav S., Prabhu, R. K., Priddy, Lauren B., Bouvard, Jean-Luc, Marin, Esteban, Horstemeyer, Mark F., Liao, Jun, and Williams, Lakiesha N. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression. United States: N. p., 2019. Web. doi:10.3390/bioengineering6020049.
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Chen, Joseph, Patnaik, Sourav S., Prabhu, R. K., Priddy, Lauren B., Bouvard, Jean-Luc, Marin, Esteban, Horstemeyer, Mark F., Liao, Jun, & Williams, Lakiesha N. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression. United States. https://doi.org/10.3390/bioengineering6020049
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Chen, Joseph, Patnaik, Sourav S., Prabhu, R. K., Priddy, Lauren B., Bouvard, Jean-Luc, Marin, Esteban, Horstemeyer, Mark F., Liao, Jun, and Williams, Lakiesha N. Thu . "Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression". United States. https://doi.org/10.3390/bioengineering6020049. https://www.osti.gov/servlets/purl/1629621.
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@article{osti_1629621,
title = {Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression},
author = {Chen, Joseph and Patnaik, Sourav S. and Prabhu, R. K. and Priddy, Lauren B. and Bouvard, Jean-Luc and Marin, Esteban and Horstemeyer, Mark F. and Liao, Jun and Williams, Lakiesha N.},
abstractNote = {In automobile accidents, abdominal injuries are often life-threatening yet not apparent at the time of initial injury. The liver is the most commonly injured abdominal organ from this type of trauma. In contrast to current safety tests involving crash dummies, a more detailed, efficient approach to predict the risk of human injuries is computational modelling and simulations. Further, the development of accurate computational human models requires knowledge of the mechanical properties of tissues in various stress states, especially in high-impact scenarios. In this study, a polymeric split-Hopkinson pressure bar (PSHPB) was utilized to apply various high strain rates to porcine liver tissue to investigate its material behavior during high strain rate compression. Liver tissues were subjected to high strain rate impacts at 350, 550, 1000, and 1550 s–1. Tissue directional dependency was also explored by PSHPB testing along three orthogonal directions of liver at a strain rate of 350 s–1. Histology of samples from each of the three directions was performed to examine the structural properties of porcine liver. Porcine liver tissue showed an inelastic and strain rate-sensitive response at high strain rates. The liver tissue was found lacking directional dependency, which could be explained by the isotropic microstructure observed after staining and imaging. Furthermore, finite element analysis (FEA) of the PSHPB tests revealed the stress profile inside liver tissue and served as a validation of PSHPB methodology. The present findings can assist in the development of more accurate computational models of liver tissue at high-rate impact conditions allowing for understanding of subfailure and failure mechanisms.},
doi = {10.3390/bioengineering6020049},
journal = {Bioengineering},
number = 2,
volume = 6,
place = {United States},
year = {Thu May 30 00:00:00 EDT 2019},
month = {Thu May 30 00:00:00 EDT 2019}
}
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https://doi.org/10.3390/bioengineering6020049
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High strain rate compressive properties of bovine muscle tissue determined using a split Hopkinson bar apparatus
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Compressive strain rate sensitivity of ballistic gelatin
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Dynamic compressive response of bovine liver tissues
journal, January 2011

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Characterization of viscoelastic properties of polymer bar using iterative deconvolution in the time domain
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