Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects
Abstract
Designing protective systems for the human head—and, hence, the brain—requires understanding the brain’s microstructural response to mechanical insults. We present the behavior of wet and dry porcine brain undergoing quasi-static and high strain rate mechanical deformations to unravel the effect of hydration on the brain’s biomechanics. Here, native ‘wet’ brain samples contained ~80% (mass/mass) water content and ‘dry’ brain samples contained ~0% (mass/mass) water content. First, the wet brain incurred a large initial peak stress that was not exhibited by the dry brain. Second, stress levels for the dry brain were greater than the wet brain. Third, the dry brain stress–strain behavior was characteristic of ductile materials with a yield point and work hardening; however, the wet brain showed a typical concave inflection that is often manifested by polymers. Finally, finite element analysis (FEA) of the brain’s high strain rate response for samples with various proportions of water and dry brain showed that water played a major role in the initial hardening trend. Therefore, hydration level plays a key role in brain tissue micromechanics, and the incorporation of this hydration effect on the brain’s mechanical response in simulated injury scenarios or virtual human-centric protective headgear design is essential.
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1512324
- Grant/Contract Number:
- FC26-06NT42755
- Resource Type:
- Published Article
- Journal Name:
- Bioengineering
- Additional Journal Information:
- Journal Name: Bioengineering Journal Volume: 6 Journal Issue: 2; Journal ID: ISSN 2306-5354
- Publisher:
- MDPI AG
- Country of Publication:
- Switzerland
- Language:
- English
Citation Formats
Prabhu, Raj K., Begonia, Mark T., Whittington, Wilburn R., Murphy, Michael A., Mao, Yuxiong, Liao, Jun, Williams, Lakiesha N., Horstemeyer, Mark F., and Sheng, Jianping. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects. Switzerland: N. p., 2019.
Web. doi:10.3390/bioengineering6020040.
Prabhu, Raj K., Begonia, Mark T., Whittington, Wilburn R., Murphy, Michael A., Mao, Yuxiong, Liao, Jun, Williams, Lakiesha N., Horstemeyer, Mark F., & Sheng, Jianping. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects. Switzerland. https://doi.org/10.3390/bioengineering6020040
Prabhu, Raj K., Begonia, Mark T., Whittington, Wilburn R., Murphy, Michael A., Mao, Yuxiong, Liao, Jun, Williams, Lakiesha N., Horstemeyer, Mark F., and Sheng, Jianping. Tue .
"Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects". Switzerland. https://doi.org/10.3390/bioengineering6020040.
@article{osti_1512324,
title = {Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects},
author = {Prabhu, Raj K. and Begonia, Mark T. and Whittington, Wilburn R. and Murphy, Michael A. and Mao, Yuxiong and Liao, Jun and Williams, Lakiesha N. and Horstemeyer, Mark F. and Sheng, Jianping},
abstractNote = {Designing protective systems for the human head—and, hence, the brain—requires understanding the brain’s microstructural response to mechanical insults. We present the behavior of wet and dry porcine brain undergoing quasi-static and high strain rate mechanical deformations to unravel the effect of hydration on the brain’s biomechanics. Here, native ‘wet’ brain samples contained ~80% (mass/mass) water content and ‘dry’ brain samples contained ~0% (mass/mass) water content. First, the wet brain incurred a large initial peak stress that was not exhibited by the dry brain. Second, stress levels for the dry brain were greater than the wet brain. Third, the dry brain stress–strain behavior was characteristic of ductile materials with a yield point and work hardening; however, the wet brain showed a typical concave inflection that is often manifested by polymers. Finally, finite element analysis (FEA) of the brain’s high strain rate response for samples with various proportions of water and dry brain showed that water played a major role in the initial hardening trend. Therefore, hydration level plays a key role in brain tissue micromechanics, and the incorporation of this hydration effect on the brain’s mechanical response in simulated injury scenarios or virtual human-centric protective headgear design is essential.},
doi = {10.3390/bioengineering6020040},
journal = {Bioengineering},
number = 2,
volume = 6,
place = {Switzerland},
year = {Tue May 07 00:00:00 EDT 2019},
month = {Tue May 07 00:00:00 EDT 2019}
}
https://doi.org/10.3390/bioengineering6020040
Works referenced in this record:
How to test very soft biological tissues in extension?
journal, May 2001
- Miller, Karol
- Journal of Biomechanics, Vol. 34, Issue 5
In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury
journal, January 2006
- Bayly, Philip V.; Black, Erin E.; Pedersen, Rachel C.
- Journal of Biomechanics, Vol. 39, Issue 6
The Epidemiology and Impact of Traumatic Brain Injury: A Brief Overview
journal, January 2006
- Langlois, Jean A.; Rutland-Brown, Wesley; Wald, Marlena M.
- Journal of Head Trauma Rehabilitation, Vol. 21, Issue 5
An Investigation of the Mechanical Properties of Materials at very High Rates of Loading
journal, November 1949
- Kolsky, H.
- Proceedings of the Physical Society. Section B, Vol. 62, Issue 11
A New Constitutive Relation for Rubber
journal, March 1996
- Gent, A. N.
- Rubber Chemistry and Technology, Vol. 69, Issue 1
High Tolerance and Delayed Elastic Response of Cultured Axons to Dynamic Stretch Injury
journal, June 1999
- Smith, Douglas H.; Wolf, John A.; Lusardi, Theresa A.
- The Journal of Neuroscience, Vol. 19, Issue 11
Mechanical Characterization of Brain Tissue in High-Rate Compression
journal, January 2007
- Tamura, Atsutaka; Hayashi, Sadayuki; Watanabe, Isao
- Journal of Biomechanical Science and Engineering, Vol. 2, Issue 3
Shock wave induced damage in kidney tissue
journal, March 2005
- Weinberg, K.; Ortiz, M.
- Computational Materials Science, Vol. 32, Issue 3-4
Thermodynamic properties of fcc metals at high temperatures
journal, August 1981
- MacDonald, Rosemary A.; MacDonald, William M.
- Physical Review B, Vol. 24, Issue 4
Tissue-Level Thresholds for Axonal Damage in an Experimental Model of Central Nervous System White Matter Injury
journal, July 2000
- Bain, Allison C.; Meaney, David F.
- Journal of Biomechanical Engineering, Vol. 122, Issue 6
Rheological Response of Human Brain Tissue in Shear
journal, December 1972
- Shuck, L. Z.; Advani, S. H.
- Journal of Basic Engineering, Vol. 94, Issue 4
Mechanical properties of brain tissue in tension
journal, April 2002
- Miller, Karol; Chinzei, Kiyoyuki
- Journal of Biomechanics, Vol. 35, Issue 4
The Influence of Strain Rate Dependency on the Structure–Property Relations of Porcine Brain
journal, May 2010
- Begonia, Mark T.; Prabhu, Raj; Liao, Jun
- Annals of Biomedical Engineering, Vol. 38, Issue 10
Single-crystal elasto-viscoplasticity: application to texture evolution in polycrystalline metals at large strains
journal, December 2004
- Anand, Lallit
- Computer Methods in Applied Mechanics and Engineering, Vol. 193, Issue 48-51
An In Vitro Uniaxial Stretch Model for Axonal Injury
journal, May 2003
- Pfister, Bryan J.; Weihs, Timothy P.; Betenbaugh, Michael
- Annals of Biomedical Engineering, Vol. 31, Issue 5
Mechanics of head Injuries
journal, October 1943
- Holbourn, A. H. S.
- The Lancet, Vol. 242, Issue 6267
Generalization of split Hopkinson bar technique to use viscoelastic bars
journal, June 1995
- Gary, G.; Klepaczko, J. R.; Zhao, H.
- International Journal of Impact Engineering, Vol. 16, Issue 3
Coupled experiment/finite element analysis on the mechanical response of porcine brain under high strain rates
journal, October 2011
- Prabhu, R.; Horstemeyer, M. F.; Tucker, M. T.
- Journal of the Mechanical Behavior of Biomedical Materials, Vol. 4, Issue 7
A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
journal, January 2015
- Prabhu, Rajkumar; Whittington, Wilburn R.; Patnaik, Sourav S.
- Journal of Visualized Experiments, Issue 99
Material and Structural Modeling Aspects of Brain Tissue Deformation under Dynamic Loads
journal, January 2019
- Ratajczak, Monika; Ptak, Mariusz; Chybowski, Leszek
- Materials, Vol. 12, Issue 2
Modeling and validation of the large deformation inelastic response of amorphous polymers over a wide range of temperatures and strain rates
journal, December 2007
- Richeton, J.; Ahzi, S.; Vecchio, K. S.
- International Journal of Solids and Structures, Vol. 44, Issue 24
The decomposition F=FeFp, material symmetry, and plastic irrotationality for solids that are isotropic-viscoplastic or amorphous
journal, September 2005
- Gurtin, Morton E.; Anand, Lallit
- International Journal of Plasticity, Vol. 21, Issue 9
Development and Testing of Advanced Cork Composite Sandwiches for Energy-Absorbing Structures
journal, February 2019
- Kaczyński, Paweł; Ptak, Mariusz; A. O. Fernandes, Fábio
- Materials, Vol. 12, Issue 5
A thermo-mechanically coupled theory for large deformations of amorphous polymers. Part II: Applications
journal, August 2009
- Ames, Nicoli M.; Srivastava, Vikas; Chester, Shawn A.
- International Journal of Plasticity, Vol. 25, Issue 8
Material characterization of the brainstem from oscillatory shear tests
journal, September 1998
- Arbogast, Kristy B.; Margulies, Susan S.
- Journal of Biomechanics, Vol. 31, Issue 9
Influence of temperature and strain rate on the mechanical behavior of three amorphous polymers: Characterization and modeling of the compressive yield stress
journal, April 2006
- Richeton, J.; Ahzi, S.; Vecchio, K. S.
- International Journal of Solids and Structures, Vol. 43, Issue 7-8
Dynamic mechanical response of bovine gray matter and white matter brain tissues under compression
journal, April 2009
- Pervin, Farhana; Chen, Weinong W.
- Journal of Biomechanics, Vol. 42, Issue 6
Dynamic mechanical properties of human brain tissue
journal, July 1969
- Fallenstein, G. T.; Hulce, V. D.; Melvin, J. W.
- Journal of Biomechanics, Vol. 2, Issue 3
Strain rate effects on the ratio of recoverable to non-recoverable strain in linear polyethylene
journal, February 1978
- Fotheringham, D. G.; Cherry, B. W.
- Journal of Materials Science, Vol. 13, Issue 2
Constitutive Modeling of Rate-Dependent Stress–Strain Behavior of Human Liver in Blunt Impact Loading
journal, August 2008
- Sparks, Jessica L.; Dupaix, Rebecca B.
- Annals of Biomedical Engineering, Vol. 36, Issue 11
Experimental Observation of high Strain rate Responses of Porcine Brain, Liver, and Tendon
journal, May 2016
- Clemmer, John; Prabhu, Raj; Chen, Joseph
- Journal of Mechanics in Medicine and Biology, Vol. 16, Issue 03
Fast quantitative mapping of absolute water content with full brain coverage
journal, September 2008
- Neeb, H.; Ermer, V.; Stocker, T.
- NeuroImage, Vol. 42, Issue 3
Mechanical properties of tissues of the nervous system
journal, July 1968
- Ommaya, Ayub K.
- Journal of Biomechanics, Vol. 1, Issue 2
Traumatic Brain Injury in the United States: A Public Health Perspective
journal, January 1999
- Thurman, David J.; Alverson, Clinton; Dunn, Kathleen A.
- Journal of Head Trauma Rehabilitation, Vol. 14, Issue 6
Unconfined compression of white matter
journal, January 2007
- Cheng, Shaokoon; Bilston, Lynne E.
- Journal of Biomechanics, Vol. 40, Issue 1
Brain tissue deforms similarly to filled elastomers and follows consolidation theory
journal, December 2006
- Franceschini, G.; Bigoni, D.; Regitnig, P.
- Journal of the Mechanics and Physics of Solids, Vol. 54, Issue 12
Shear Properties of Human Brain Tissue
journal, November 1997
- Donnelly, B. R.; Medige, J.
- Journal of Biomechanical Engineering, Vol. 119, Issue 4
Most recent results in the biomechanics of the brain
journal, April 2005
- Miller, Karol
- Journal of Biomechanics, Vol. 38, Issue 4
On the kinematics of finite strain plasticity
journal, January 1989
- Boyce, M. C.; Weber, G. G.; Parks, D. M.
- Journal of the Mechanics and Physics of Solids, Vol. 37, Issue 5
The Effects of Momentary Stresses in Metals
journal, January 1904
- Hopkinson, Bertram
- Proceedings of the Royal Society of London, Vol. 74, Issue 497-506
Elastic-Plastic Deformation at Finite Strains
journal, March 1969
- Lee, E. H.
- Journal of Applied Mechanics, Vol. 36, Issue 1
The Lucite Calvarium—A Method for Direct Observation of the Brain
journal, November 1946
- Pudenz, Robert H.; Shelden, C. Hunter
- Journal of Neurosurgery, Vol. 3, Issue 6
A general inelastic internal state variable model for amorphous glassy polymers
journal, June 2010
- Bouvard, J. L.; Ward, D. K.; Hossain, D.
- Acta Mechanica, Vol. 213, Issue 1-2
An analysis of texture and plastic spin for planar polycrystals
journal, August 1993
- Prantil, Vincent C.; Jenkins, James T.; Dawson, Paul R.
- Journal of the Mechanics and Physics of Solids, Vol. 41, Issue 8
The effect of varying strain rates and stress states on the plasticity, damage, and fracture of aluminum alloys
journal, October 2010
- Tucker, M. T.; Horstemeyer, M. F.; Whittington, W. R.
- Mechanics of Materials, Vol. 42, Issue 10
Dynamic and quasi-static compressive response of porcine muscle
journal, January 2007
- Song, Bo; Chen, Weinong; Ge, Yun
- Journal of Biomechanics, Vol. 40, Issue 13
Allgemeine Kontinuumstheorie der Versetzungen und Eigenspannungen
journal, January 1959
- Kröner, Ekkehart
- Archive for Rational Mechanics and Analysis, Vol. 4, Issue 1