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Title: Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma

Abstract

Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made research of pulmonary injury a major priority. Lungs have a complex structure, with multiple types of tissues necessary to allow successful respiration. The soft, porous parenchyma is the component of the lung which contains the alveoli responsible for gas exchange. Parenchyma is also the portion which is most susceptible to traumatic injury. Finite element simulations are an important tool for studying traumatic injury to the human body. These simulations rely on material properties to accurately recreate real world mechanical behaviors. Previous studies have explored the mechanical properties of lung tissues, specifically parenchyma. These studies have assumed material isotropy but, to our knowledge, no study has thoroughly tested and quantified this assumption. This study presents a novel methodology for assessing isotropy in a tissue, and applies these methods to porcine lung parenchyma. Briefly, lung parenchyma samples were dissected so as to be aligned with one of the three anatomical planes, sagittal, frontal, and transverse, and then subjected to compressive mechanical testing. Stress-strain curvesmore » from these tests were statistically compared by a novel method for differences in stresses and strains at percentages of the curve. Histological samples aligned with the anatomical planes were also examined by qualitative and quantitative methods to determine any differences in the microstructural morphology. Our study showed significant evidence to support the hypothesis that lung parenchyma behaves isotropically.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1]
+ Show Author Affiliations
  1. Mississippi State Univ., Starkville, MS (United States). Department of Agricultural and Biological Engineering
  2. University of Georgia, Athens, GA 30602, (United States). Department of Genetics
Publication Date:
Research Org.:
Mississippi State Univ., Starkville, MS (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1628448
Grant/Contract Number:  
FC26-06NT42755
Resource Type:
Accepted Manuscript
Journal Name:
Materials
Additional Journal Information:
Journal Volume: 8; Journal Issue: 5; Journal ID: ISSN 1996-1944
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
Materials Science

Citation Formats

Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, and Williams, Lakiesha. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. United States: N. p., 2015. Web. doi:10.3390/ma8052454.
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Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, & Williams, Lakiesha. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. United States. doi:10.3390/ma8052454.
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Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, and Williams, Lakiesha. Fri . "Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma". United States. doi:10.3390/ma8052454. https://www.osti.gov/servlets/purl/1628448.
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@article{osti_1628448,
title = {Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma},
author = {Weed, Benjamin and Patnaik, Sourav and Rougeau-Browning, Mary and Brazile, Bryn and Liao, Jun and Prabhu, Raj and Williams, Lakiesha},
abstractNote = {Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made research of pulmonary injury a major priority. Lungs have a complex structure, with multiple types of tissues necessary to allow successful respiration. The soft, porous parenchyma is the component of the lung which contains the alveoli responsible for gas exchange. Parenchyma is also the portion which is most susceptible to traumatic injury. Finite element simulations are an important tool for studying traumatic injury to the human body. These simulations rely on material properties to accurately recreate real world mechanical behaviors. Previous studies have explored the mechanical properties of lung tissues, specifically parenchyma. These studies have assumed material isotropy but, to our knowledge, no study has thoroughly tested and quantified this assumption. This study presents a novel methodology for assessing isotropy in a tissue, and applies these methods to porcine lung parenchyma. Briefly, lung parenchyma samples were dissected so as to be aligned with one of the three anatomical planes, sagittal, frontal, and transverse, and then subjected to compressive mechanical testing. Stress-strain curves from these tests were statistically compared by a novel method for differences in stresses and strains at percentages of the curve. Histological samples aligned with the anatomical planes were also examined by qualitative and quantitative methods to determine any differences in the microstructural morphology. Our study showed significant evidence to support the hypothesis that lung parenchyma behaves isotropically.},
doi = {10.3390/ma8052454},
journal = {Materials},
number = 5,
volume = 8,
place = {United States},
year = {2015},
month = {5}
}
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DOI:  10.3390/ma8052454
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Works referenced in this record:

Injuries From Explosions: Physics, Biophysics, Pathology, and Required Research Focus
journal, January 2009

  • Champion, Howard R.; Holcomb, John B.; Young, Lee Ann
  • The Journal of Trauma: Injury, Infection, and Critical Care, Vol. 66, Issue 5
  • DOI: 10.1097/TA.0b013e3181a27e7f

Blast injuries
journal, August 2009

The pathology of primary blast overpressure injury
journal, July 1997

Biological response to blast overpressure: A summary of modeling
journal, July 1997

A model of blast overpressure injury to the lung
journal, February 1996

  • Stuhmiller, James H.; Ho, Kevin H. -H.; Vander Vorst, Michael J.
  • Journal of Biomechanics, Vol. 29, Issue 2
  • DOI: 10.1016/0021-9290(95)00039-9

The role of stress waves in thoracic visceral injury from blast loading: Modification of stress transmission by foams and high-density materials
journal, January 1991

Computer Modeling of Thoracic Response to Blast
journal, January 1988

  • Stuhmiller, J. H.; Chuong, C. J.; Phillips, Maj(P.) Y. Y.
  • The Journal of Trauma: Injury, Infection, and Critical Care, Vol. 28, Issue Supplement
  • DOI: 10.1097/00005373-198801001-00027

Flail chest injuries: A review of outcomes and treatment practices from the National Trauma Data Bank
journal, January 2014

  • Dehghan, Niloofar; de Mestral, Charles; McKee, Michael D.
  • Journal of Trauma and Acute Care Surgery, Vol. 76, Issue 2
  • DOI: 10.1097/TA.0000000000000086

Pulmonary laceration secondary to a traumatic soccer injury: a case report and review of the literature
journal, November 2013

  • Idriz, Sanjin; Abbas, Ausami; Sadigh, Sufi
  • The American Journal of Emergency Medicine, Vol. 31, Issue 11
  • DOI: 10.1016/j.ajem.2013.06.032

Modeling of weak blast wave propagation in the lung
journal, January 2006

Blast Trauma: The Fourth Weapon of Mass Destruction
journal, December 2005

Blast Lung Injury
journal, January 2006

  • Sasser, Scott M.; Sattin, Richard W.; Hunt, Richard C.
  • Prehospital Emergency Care, Vol. 10, Issue 2
  • DOI: 10.1080/10903120500540912

Finite element–based injury metrics for pulmonary contusion via concurrent model optimization
journal, August 2010

  • Gayzik, F. Scott; Hoth, J. Jason; Stitzel, Joel D.
  • Biomechanics and Modeling in Mechanobiology, Vol. 10, Issue 4
  • DOI: 10.1007/s10237-010-0251-5

A Finite Element Model for Macroscopic Deformation of the Lung
journal, February 1980

  • Vawter, D. L.
  • Journal of Biomechanical Engineering, Vol. 102, Issue 1
  • DOI: 10.1115/1.3138193

Lung tissue mechanics as an emergent phenomenon
journal, April 2011

An implicit elastic theory for lung parenchyma
journal, January 2013

Measurements of mechanical anisotropy in brain tissue and implications for transversely isotropic material models of white matter
journal, July 2013

  • Feng, Yuan; Okamoto, Ruth J.; Namani, Ravi
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 23
  • DOI: 10.1016/j.jmbbm.2013.04.007

Mechanical anisotropy of inflated elastic tissue from the pig aorta
journal, August 2010

Multiaxial Mechanical Behavior of Biological Materials
journal, August 2003

Stress State and Strain Rate Dependence of the Human Placenta
journal, May 2012

  • Weed, Benjamin C.; Borazjani, Ali; Patnaik, Sourav S.
  • Annals of Biomedical Engineering, Vol. 40, Issue 10
  • DOI: 10.1007/s10439-012-0588-2
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