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Title: Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma

Abstract

Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made research of pulmonary injury a major priority. Lungs have a complex structure, with multiple types of tissues necessary to allow successful respiration. The soft, porous parenchyma is the component of the lung which contains the alveoli responsible for gas exchange. Parenchyma is also the portion which is most susceptible to traumatic injury. Finite element simulations are an important tool for studying traumatic injury to the human body. These simulations rely on material properties to accurately recreate real world mechanical behaviors. Previous studies have explored the mechanical properties of lung tissues, specifically parenchyma. These studies have assumed material isotropy but, to our knowledge, no study has thoroughly tested and quantified this assumption. This study presents a novel methodology for assessing isotropy in a tissue, and applies these methods to porcine lung parenchyma. Briefly, lung parenchyma samples were dissected so as to be aligned with one of the three anatomical planes, sagittal, frontal, and transverse, and then subjected to compressive mechanical testing. Stress-strain curvesmore » from these tests were statistically compared by a novel method for differences in stresses and strains at percentages of the curve. Histological samples aligned with the anatomical planes were also examined by qualitative and quantitative methods to determine any differences in the microstructural morphology. Our study showed significant evidence to support the hypothesis that lung parenchyma behaves isotropically.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1]
+ Show Author Affiliations
  1. Mississippi State Univ., Starkville, MS (United States). Department of Agricultural and Biological Engineering
  2. University of Georgia, Athens, GA 30602, (United States). Department of Genetics
Publication Date:
Research Org.:
Mississippi State Univ., Starkville, MS (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1628448
Grant/Contract Number:  
FC26-06NT42755
Resource Type:
Accepted Manuscript
Journal Name:
Materials
Additional Journal Information:
Journal Volume: 8; Journal Issue: 5; Journal ID: ISSN 1996-1944
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
Materials Science

Citation Formats

Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, and Williams, Lakiesha. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. United States: N. p., 2015. Web. https://doi.org/10.3390/ma8052454.
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Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, & Williams, Lakiesha. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. United States. https://doi.org/10.3390/ma8052454
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Weed, Benjamin, Patnaik, Sourav, Rougeau-Browning, Mary, Brazile, Bryn, Liao, Jun, Prabhu, Raj, and Williams, Lakiesha. Fri . "Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma". United States. https://doi.org/10.3390/ma8052454. https://www.osti.gov/servlets/purl/1628448.
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@article{osti_1628448,
title = {Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma},
author = {Weed, Benjamin and Patnaik, Sourav and Rougeau-Browning, Mary and Brazile, Bryn and Liao, Jun and Prabhu, Raj and Williams, Lakiesha},
abstractNote = {Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made research of pulmonary injury a major priority. Lungs have a complex structure, with multiple types of tissues necessary to allow successful respiration. The soft, porous parenchyma is the component of the lung which contains the alveoli responsible for gas exchange. Parenchyma is also the portion which is most susceptible to traumatic injury. Finite element simulations are an important tool for studying traumatic injury to the human body. These simulations rely on material properties to accurately recreate real world mechanical behaviors. Previous studies have explored the mechanical properties of lung tissues, specifically parenchyma. These studies have assumed material isotropy but, to our knowledge, no study has thoroughly tested and quantified this assumption. This study presents a novel methodology for assessing isotropy in a tissue, and applies these methods to porcine lung parenchyma. Briefly, lung parenchyma samples were dissected so as to be aligned with one of the three anatomical planes, sagittal, frontal, and transverse, and then subjected to compressive mechanical testing. Stress-strain curves from these tests were statistically compared by a novel method for differences in stresses and strains at percentages of the curve. Histological samples aligned with the anatomical planes were also examined by qualitative and quantitative methods to determine any differences in the microstructural morphology. Our study showed significant evidence to support the hypothesis that lung parenchyma behaves isotropically.},
doi = {10.3390/ma8052454},
journal = {Materials},
number = 5,
volume = 8,
place = {United States},
year = {2015},
month = {5}
}
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https://doi.org/10.3390/ma8052454
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