An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions
Abstract
Marine neurotoxins are natural products produced by phytoplankton and select species of invertebrates and fish. These compounds interact with voltage-gated sodium, potassium and calcium channels and modulate the flux of these ions into various cell types. This review provides a summary of marine neurotoxins, including their structures, molecular targets and pharmacologies. Saxitoxin and its derivatives, collectively referred to as paralytic shellfish toxins (PSTs), are unique among neurotoxins in that they are found in both marine and freshwater environments by organisms inhabiting two kingdoms of life. Prokaryotic cyanobacteria are responsible for PST production in freshwater systems, while eukaryotic dinoflagellates are the main producers in marine waters. Bioaccumulation by filter-feeding bivalves and fish and subsequent transfer through the food web results in the potentially fatal human illnesses, paralytic shellfish poisoning and saxitoxin pufferfish poisoning. These illnesses are a result of saxitoxin’s ability to bind to the voltage-gated sodium channel, blocking the passage of nerve impulses and leading to death via respiratory paralysis. Recent advances in saxitoxin research are discussed, including the molecular biology of toxin synthesis, new protein targets, association with metal-binding motifs and methods of detection. The eco-evolutionary role(s) PSTs may serve for phytoplankton species that produce them are also discussed.
- Authors:
-
- Univ. of Tennessee, Knoxville, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). UT-ORNL Joint Inst. of Biological Sciences
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- OSTI Identifier:
- 1628456
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Marine Drugs
- Additional Journal Information:
- Journal Volume: 11; Journal Issue: 4; Journal ID: ISSN 1660-3397
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; pharmacology & pharmacy; neurotoxin; saxitoxin; ion channels; copper transporter; phytoplankton; paralytic shellfish toxin
Citation Formats
Cusick, Kathleen, and Sayler, Gary. An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions. United States: N. p., 2013.
Web. doi:10.3390/md11040991.
Cusick, Kathleen, & Sayler, Gary. An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions. United States. https://doi.org/10.3390/md11040991
Cusick, Kathleen, and Sayler, Gary. Wed .
"An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions". United States. https://doi.org/10.3390/md11040991. https://www.osti.gov/servlets/purl/1628456.
@article{osti_1628456,
title = {An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions},
author = {Cusick, Kathleen and Sayler, Gary},
abstractNote = {Marine neurotoxins are natural products produced by phytoplankton and select species of invertebrates and fish. These compounds interact with voltage-gated sodium, potassium and calcium channels and modulate the flux of these ions into various cell types. This review provides a summary of marine neurotoxins, including their structures, molecular targets and pharmacologies. Saxitoxin and its derivatives, collectively referred to as paralytic shellfish toxins (PSTs), are unique among neurotoxins in that they are found in both marine and freshwater environments by organisms inhabiting two kingdoms of life. Prokaryotic cyanobacteria are responsible for PST production in freshwater systems, while eukaryotic dinoflagellates are the main producers in marine waters. Bioaccumulation by filter-feeding bivalves and fish and subsequent transfer through the food web results in the potentially fatal human illnesses, paralytic shellfish poisoning and saxitoxin pufferfish poisoning. These illnesses are a result of saxitoxin’s ability to bind to the voltage-gated sodium channel, blocking the passage of nerve impulses and leading to death via respiratory paralysis. Recent advances in saxitoxin research are discussed, including the molecular biology of toxin synthesis, new protein targets, association with metal-binding motifs and methods of detection. The eco-evolutionary role(s) PSTs may serve for phytoplankton species that produce them are also discussed.},
doi = {10.3390/md11040991},
journal = {Marine Drugs},
number = 4,
volume = 11,
place = {United States},
year = {Wed Mar 27 00:00:00 EDT 2013},
month = {Wed Mar 27 00:00:00 EDT 2013}
}
Works referenced in this record:
Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon.
journal, February 1982
- Kao, C. Y.; Walker, S. E.
- The Journal of Physiology, Vol. 323, Issue 1
Evidence That Tetrodotoxin and Saxitoxin Act at a Metal Cation Binding Site in the Sodium Channels of Nerve Membrane
journal, October 1974
- Henderson, R.; Ritchie, J. M.; Strichartz, G. R.
- Proceedings of the National Academy of Sciences, Vol. 71, Issue 10
A tissue culture assay for tetrodotoxin, saxitoxin and related toxins
journal, January 1988
- Kogure, Kazuhiro; Tamplin, Mark L.; Simidu, Usio
- Toxicon, Vol. 26, Issue 2
The pKa's of saxitoxin
journal, November 1980
- Rogers, R. Scott; Rapoport, Henry
- Journal of the American Chemical Society, Vol. 102, Issue 24
Intracellular Localization of Saxitoxins in the Dinoflagellate Gonyaulax Tamarensis1
journal, March 1988
- Anderson, Donald M.; Cheng, Toni Po-On
- Journal of Phycology, Vol. 24, Issue 1
Induction of toxin production in dinoflagellates: the grazer makes a difference
journal, February 2008
- Bergkvist, Johanna; Selander, Erik; Pavia, Henrik
- Oecologia, Vol. 156, Issue 1
Biological control of harmful algal blooms: A modelling study
journal, July 2006
- Solé, Jordi; Estrada, Marta; Garcia-Ladona, Emilio
- Journal of Marine Systems, Vol. 61, Issue 3-4
Characterization of Saxitoxin Binding to Saxiphilin, a Relative of the Transferrin Family That Displays pH-Dependent Ligand Binding
journal, October 1994
- Llewellyn, Lyndon E.; Moczydlowski, Edward G.
- Biochemistry, Vol. 33, Issue 40
Biochemical Characterization of Paralytic Shellfish Toxin Biosynthesis in Vitro
journal, June 2007
- Kellmann, Ralf; Neilan, Brett A.
- Journal of Phycology, Vol. 43, Issue 3
Toxin content and toxic effects of the dinoflagellate Gyrodinium corsicum (Paulmier) on the ingestion and survival rates of the copepods Acartia grani and Euterpina acutifrons
journal, September 2005
- da Costa, Rauquírio Marinho; Franco, José; Cacho, Emiliano
- Journal of Experimental Marine Biology and Ecology, Vol. 322, Issue 2
DNA probes, targeting large sub‐unit rRNA, for the rapid identification of the paralytic shellfish poison producing dinoflagellate, Gymnodinium catenatum
journal, December 2007
- Rhodes, Lesley; Smith, Kirsty; De Salas, Miguel
- New Zealand Journal of Marine and Freshwater Research, Vol. 41, Issue 4
Voltage-gated ion channels and gating modifier toxins
journal, February 2007
- Catterall, William A.; Cestèle, Sandrine; Yarov-Yarovoy, Vladimir
- Toxicon, Vol. 49, Issue 2
Flow cytometric detection of saxitoxins using fluorescent voltage-sensitive dyes
journal, July 2007
- Manger, Ronald; Woodle, Doug; Berger, Andrew
- Analytical Biochemistry, Vol. 366, Issue 2
Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport
journal, January 1994
- Dancis, Andrew; Yuan, Daniel S.; Haile, David
- Cell, Vol. 76, Issue 2
Non-Traditional Vectors for Paralytic Shellfish Poisoning
journal, June 2008
- Deeds, Jonathan; Landsberg, Jan; Etheridge, Stacey
- Marine Drugs, Vol. 6, Issue 2
Expression of Saxiphilin in Insect Cells and Localization of the Saxitoxin-Binding Site to the C-Terminal Domain Homologous to the C-Lobe of Transferrins
journal, October 1995
- Morabito, Maria A.; Llewellyn, Lyndon E.; Moczydlowski, Edward G.
- Biochemistry, Vol. 34, Issue 40
Regulated Copper Uptake in Chlamydomonas reinhardtii in Response to Copper Availability
journal, October 1996
- Hill, K. L.; Hassett, R.; Kosman, D.
- Plant Physiology, Vol. 112, Issue 2
Toxic marine phytoplankton, zooplankton grazers, and pelagic food webs
journal, July 1997
- Turner, Jefferson T.; Tester, Patricia A.
- Limnology and Oceanography, Vol. 42, Issue 5part2
Microalgal metabolites
journal, June 2003
- Shimizu, Yuzuru
- Current Opinion in Microbiology, Vol. 6, Issue 3
Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture
journal, February 2006
- Aller, S. G.; Unger, V. M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 10
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II
journal, December 1989
- Noda, Masaharu; Suzuki, Harukazu; Numa, Shosaku
- FEBS Letters, Vol. 259, Issue 1
The Relevance of Marine Chemical Ecology to Plankton and Ecosystem Function: An Emerging Field
journal, September 2011
- Ianora, Adrianna; Bentley, Matthew G.; Caldwell, Gary S.
- Marine Drugs, Vol. 9, Issue 9
A structural perspective on copper uptake in eukaryotes
journal, January 2007
- De Feo, Christopher J.; Aller, Stephen G.; Unger, Vinzenz M.
- BioMetals, Vol. 20, Issue 3-4
Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5
journal, January 2009
- Mihali, Troco K.; Kellmann, Ralf; Neilan, Brett A.
- BMC Biochemistry, Vol. 10, Issue 1
Saxitoxin Puffer Fish Poisoning in the United States, with the First Report of Pyrodinium bahamense as the Putative Toxin Source
journal, October 2006
- Landsberg, Jan H.; Hall, Sherwood; Johannessen, Jan N.
- Environmental Health Perspectives, Vol. 114, Issue 10
Two Chlamydomonas CTR Copper Transporters with a Novel Cys-Met Motif Are Localized to the Plasma Membrane and Function in Copper Assimilation
journal, March 2009
- Page, M. Dudley; Kropat, Janette; Hamel, Patrice P.
- The Plant Cell, Vol. 21, Issue 3
Use of Loop-Mediated Isothermal Amplification of the IS 900 Sequence for Rapid Detection of Cultured Mycobacterium avium subsp. paratuberculosis
journal, September 2003
- Enosawa, M.; Kageyama, S.; Sawai, K.
- Journal of Clinical Microbiology, Vol. 41, Issue 9
Production and characterization of antibodies against neosaxitoxin utilizing a novel immunogen Synthesis procedure
journal, January 1995
- Bürk, Christine; Usleber, Ewald; Dietrich, Richard
- Food and Agricultural Immunology, Vol. 7, Issue 4
Saxitoxin Blocks L-Type I Ca
journal, October 2003
- Su, Zhi; Sheets, Michael; Ishida, Hideyuki
- Journal of Pharmacology and Experimental Therapeutics, Vol. 308, Issue 1
A multiplex qPCR targeting hepato- and neurotoxigenic cyanobacteria of global significance
journal, March 2012
- Al-Tebrineh, Jamal; Pearson, Leanne A.; Yasar, Serhat A.
- Harmful Algae, Vol. 15
The Purification and Characterization of the Poison Produced by Gonyaulax catenella in Axenic Culture *
journal, April 1966
- Schantz, Edward J.; Lynch, Joseph M.; Vayvada, George
- Biochemistry, Vol. 5, Issue 4
Analysis of cyanobacterial toxins by hydrophilic interaction liquid chromatography–mass spectrometry
journal, February 2004
- Dell’Aversano, Carmela; Eaglesham, Geoffrey K.; Quilliam, Michael A.
- Journal of Chromatography A, Vol. 1028, Issue 1
Specific detection of the toxic dinoflagellates Alexandrium tamarense and Alexandrium catenella from single vegetative cells by a loop-mediated isothermal amplification method
journal, September 2012
- Nagai, Satoshi; Itakura, Shigeru
- Marine Genomics, Vol. 7
Chemical ecology of eukaryotic microalgae in marine ecosystems
journal, July 2003
- Cembella, Allan D.
- Phycologia, Vol. 42, Issue 4
Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin.
journal, March 1994
- Morabito, M. A.; Moczydlowski, E.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 7
Genomic understanding of dinoflagellates
journal, July 2011
- Lin, Senjie
- Research in Microbiology, Vol. 162, Issue 6
Purification and characterization of sulfotransferase specific to O-22 of 11-hydroxy saxitoxin from the toxic dinoflagellate Gymnodinium catenatum (dinophyceae)
journal, June 2002
- Yoshida, Takashi; Sako, Yoshihiko; Uchida, Aritsune
- Fisheries Science, Vol. 68, Issue 3
Marine algal toxins: origins, health effects, and their increased occurrence.
journal, March 2000
- Van Dolah, F. M.
- Environmental Health Perspectives, Vol. 108, Issue suppl 1
THE FRESHWATER CYANOBACTERIUM PLANKTOTHRIX SP. FP1: MOLECULAR IDENTIFICATION AND DETECTION OF PARALYTIC SHELLFISH POISONING TOXINS
journal, June 2000
- Pomati, Francesco; Sacchi, Silvia; Rossetti, Carlo
- Journal of Phycology, Vol. 36, Issue 3
Non-Traditional Vectors for Paralytic Shellfish Poisoning
journal, June 2008
- Deeds, Jonathan R.
- Marine Drugs, Vol. 6, Issue 2
Development of ELISAs for detecting domoic acid, okadaic acid, and saxitoxin and their applicability for the detection of marine toxins in samples collected in Belgium
journal, June 2010
- Dubois, M.; Demoulin, L.; Charlier, C.
- Food Additives & Contaminants: Part A, Vol. 27, Issue 6
Saxitoxin monitoring in three species of Florida puffer fish
journal, January 2009
- Abbott, Jay P.; Flewelling, Leanne J.; Landsberg, Jan H.
- Harmful Algae, Vol. 8, Issue 2
Neurotoxins from Marine Dinoflagellates: A Brief Review
journal, June 2008
- Wang, Da-Zhi
- Marine Drugs, Vol. 6, Issue 2
Studies on paralytic shellfish poisoning in tropical waters. Part IV. Structures of two paralytic shellfish toxins, gonyautoxins V and VI, isolated from a tropical dinoflagellate, Pyrodinium bahamense var. compressa.
journal, January 1982
- Harada, Takako; Oshima, Yasukatsu; Yasumoto, Takeshi
- Agricultural and Biological Chemistry, Vol. 46, Issue 7
Short-term and long-term effects of the toxic dinoflagellate Alexandrium minutum on the copepod Acartia clausi
journal, January 2000
- Frangópulos, M.; Guisande, C.; Maneiro, I.
- Marine Ecology Progress Series, Vol. 203
A tissue culture assay for direct detection of sodium channel blocking toxins in bacterial culture supernates
journal, April 1992
- Gallacher, S.
- FEMS Microbiology Letters, Vol. 92, Issue 1
Hurricanes, El Niño and harmful algal blooms in two sub-tropical Florida estuaries: Direct and indirect impacts
journal, February 2020
- Phlips, Edward J.; Badylak, Susan; Nelson, Natalie G.
- Scientific Reports, Vol. 10, Issue 1
A competitive displacement assay to detect saxitoxin and tetrodotoxin
journal, August 1984
- Davio, Stephen R.; Fontelo, Paulito A.
- Analytical Biochemistry, Vol. 141, Issue 1
Dynamics and physiology of saxitoxin production by the dinoflagellatesAlexandrium spp.
journal, October 1990
- Anderson, D. M.; Kulis, D. M.; Sullivan, J. J.
- Marine Biology, Vol. 104, Issue 3
Effect of mouse strain and gender on LD50 of yessotoxin
journal, September 2008
- Aune, Tore; Aasen, John A. B.; Miles, Christopher O.
- Toxicon, Vol. 52, Issue 4
Toxicity of Alexandrium lusitanicum to gastropod larvae is not caused by paralytic-shellfish-poisoning toxins
journal, August 2008
- Juhl, A. R.; Martins, C. A.; Anderson, D. M.
- Harmful Algae, Vol. 7, Issue 5
The Effects of Harmful Algal Blooms on Aquatic Organisms
journal, April 2002
- Landsberg, Jan H.
- Reviews in Fisheries Science, Vol. 10, Issue 2
Adaptive evolution of voltage-gated sodium channels: The first 800 million years
journal, June 2012
- Zakon, H. H.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue Supplement_1
Copepod grazing selection and particle discrimination on the basis of PSP toxin content
journal, January 1999
- Teegarden, Gj
- Marine Ecology Progress Series, Vol. 181
Saxitoxin, a Toxic Marine Natural Product that Targets a Multitude of Receptors
journal, August 2006
- Llewellyn, Lyndon E.
- ChemInform, Vol. 37, Issue 32
Detection of Loop-Mediated Isothermal Amplification Reaction by Turbidity Derived from Magnesium Pyrophosphate Formation
journal, November 2001
- Mori, Yasuyoshi; Nagamine, Kentaro; Tomita, Norihiro
- Biochemical and Biophysical Research Communications, Vol. 289, Issue 1
Accumulation and depuration rates of paralytic shellfish poisoning toxins in the shore crab Telmessus acutidens by feeding toxic mussels under laboratory controlled conditions
journal, February 2005
- Oikawa, Hiroshi; Satomi, Masataka; Watabe, Shugo
- Toxicon, Vol. 45, Issue 2
Saxitoxin Is a Gating Modifier of hERG K+ Channels
journal, May 2003
- Wang, Jixin; Salata, Joseph J.; Bennett, Paul B.
- The Journal of General Physiology, Vol. 121, Issue 6
Paralytic shellfish poisoning: Seafood safety and human health perspectives
journal, August 2010
- Etheridge, Stacey M.
- Toxicon, Vol. 56, Issue 2
On the Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin
journal, May 2010
- Pearson, Leanne; Mihali, Troco; Moffitt, Michelle
- Marine Drugs, Vol. 8, Issue 5
From Stop to Start: Tandem Gene Arrangement, Copy Number and Trans-Splicing Sites in the Dinoflagellate Amphidinium carterae
journal, August 2008
- Bachvaroff, Tsvetan R.; Place, Allen R.
- PLoS ONE, Vol. 3, Issue 8
Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins
journal, January 2010
- Humpage, A. R.; Magalhaes, V. F.; Froscio, S. M.
- Analytical and Bioanalytical Chemistry, Vol. 397, Issue 5
A Fluorimetric Microplate Assay for Detection and Quantitation of Toxins Causing Paralytic Shellfish Poisoning
journal, April 2003
- Louzao, Maria Carmen; Vieytes, Mercedes Rodriguez; Cabado, Ana Garcia
- Chemical Research in Toxicology, Vol. 16, Issue 4
Tetrazolium-Based Cell Bioassay for Neurotoxins Active on Voltage-Sensitive Sodium Channels: Semiautomated Assay for Saxitoxins, Brevetoxins, and Ciguatoxins
journal, October 1993
- Manger, R. L.; Leja, L. S.; Lee, S. Y.
- Analytical Biochemistry, Vol. 214, Issue 1
Loop-mediated isothermal amplification of DNA
journal, June 2000
- Notomi, T.
- Nucleic Acids Research, Vol. 28, Issue 12
Feeding strategies of the copepod Acartia clausi on single and mixed diets of toxic and non-toxic strains of the dinoflagellate Alexandrium minutum
journal, July 2006
- Barreiro, A.; Guisande, C.; Frangópulos, M.
- Marine Ecology Progress Series, Vol. 316
Origin of Saxitoxin Biosynthetic Genes in Cyanobacteria
journal, June 2009
- Moustafa, Ahmed; Loram, Jeannette E.; Hackett, Jeremiah D.
- PLoS ONE, Vol. 4, Issue 6
Copepods induce paralytic shellfish toxin production in marine dinoflagellates
journal, April 2006
- Selander, Erik; Thor, Peter; Toth, Gunilla
- Proceedings of the Royal Society B: Biological Sciences, Vol. 273, Issue 1594
A new simple screening method for the detection of paralytic shellfish poisoning toxins
journal, September 2012
- Cheng, Jinping; Pi, Shuaishuai; Ye, Shufeng
- Chinese Journal of Oceanology and Limnology, Vol. 30, Issue 5
Notes on Alexandrium population dynamics
journal, January 1997
- Wyatt, Tim; Jenkinson, Ian R.
- Journal of Plankton Research, Vol. 19, Issue 5
Extraordinary Conservation, Gene Loss, and Positive Selection in the Evolution of an Ancient Neurotoxin
journal, November 2010
- Murray, Shauna A.; Mihali, Troco K.; Neilan, Brett A.
- Molecular Biology and Evolution, Vol. 28, Issue 3
Solid-Phase Radioreceptor Assay for Paralytic Shellfish Toxins
journal, May 1993
- Vieytes, M. R.; Cabado, A. G.; Alfonso, A.
- Analytical Biochemistry, Vol. 211, Issue 1
Saxitoxin, a toxic marine natural product that targets a multitude of receptors
journal, January 2006
- Llewellyn, Lyndon E.
- Natural Product Reports, Vol. 23, Issue 2
PURIFICATION AND CHARACTERIZATION OF A SULFOTRANSFERASE SPECIFIC TO N‐21 OF SAXITOXIN AND GONYAUTOXIN 2+3 FROM THE TOXIC DINOFLAGELLATE GYMNODINIUM CATENATUM (DINOPHYCEAE)
journal, December 2001
- Sako, Yoshihiko; Yoshida, Takashi; Uchida, Aritsune
- Journal of Phycology, Vol. 37, Issue 6
Inhibition of Copper Uptake in Yeast Reveals the Copper Transporter Ctr1p As a Potential Molecular Target of Saxitoxin
journal, February 2012
- Cusick, Kathleen D.; Minkin, Steven C.; Dodani, Sheel C.
- Environmental Science & Technology, Vol. 46, Issue 5
Neuroecology, Chemical Defense, and the Keystone Species Concept
journal, December 2007
- Zimmer, Richard K.; Ferrer, Ryan P.
- The Biological Bulletin, Vol. 213, Issue 3
Structure and organization of the peridinin-chlorophyll a-binding protein gene in Gonyaulax polyedra
journal, August 1997
- Le, Q. H.; Markovic, P.; Hastings, J. W.
- Molecular and General Genetics MGG, Vol. 255, Issue 6
Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
journal, January 2011
- Stevens, Marijke; Peigneur, Steve; Tytgat, Jan
- Frontiers in Pharmacology, Vol. 2
Hydrophilic interaction liquid chromatography–mass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins
journal, July 2005
- Dell’Aversano, Carmela; Hess, Philipp; Quilliam, Michael A.
- Journal of Chromatography A, Vol. 1081, Issue 2
MICROALGAL METABOLITES: A New Perspective
journal, October 1996
- Shimizu, Yuzuru
- Annual Review of Microbiology, Vol. 50, Issue 1
Bioterrorism: Toxins as Weapons
journal, April 2012
- Anderson, Peter D.
- Journal of Pharmacy Practice, Vol. 25, Issue 2
Neurotoxins from Marine Dinoflagellates: A Brief Review
journal, June 2008
- Wang, Da-Zhi
- Marine Drugs, Vol. 6, Issue 2
Application of rRNA probes and fluorescence in situ hybridization for rapid detection of the toxic dinoflagellate Alexandrium minutum
journal, March 2012
- Tang, Xianghai; Yu, Rencheng; Zhou, Mingjiang
- Chinese Journal of Oceanology and Limnology, Vol. 30, Issue 2
Distinct Gene Number-Genome Size Relationships for Eukaryotes and Non-Eukaryotes: Gene Content Estimation for Dinoflagellate Genomes
journal, September 2009
- Hou, Yubo; Lin, Senjie
- PLoS ONE, Vol. 4, Issue 9
Dozens of Toxin-Related Genes Are Expressed in a Nontoxic Strain of the Dinoflagellate Heterocapsa circularisquama
journal, January 2012
- Salcedo, Tovah; Upadhyay, Ravi J.; Nagasaki, Keizo
- Molecular Biology and Evolution, Vol. 29, Issue 6
Direct Competitive Enzyme-Linked Immunosorbent Assay for Saxitoxin and Neosaxitoxin
journal, January 1996
- Huang, Xuan; Hsu, Kuo-Hui; Chu, Fun S.
- Journal of Agricultural and Food Chemistry, Vol. 44, Issue 4
Refinement of AOAC Official MethodSM 2005.06 Liquid Chromatography-Fluorescence Detection Method to Improve Performance Characteristics for the Determination of Paralytic Shellfish Toxins in King and Queen Scallops
journal, January 2012
- Turner, Andrew D.; Hatfield, Robert G.
- Journal of AOAC INTERNATIONAL, Vol. 95, Issue 1
Marine Algal Toxins: Origins, Health Effects, and Their Increased Occurrence
journal, March 2000
- Dolah, Frances M. Van
- Environmental Health Perspectives, Vol. 108
Transcriptome Profiling of a Toxic Dinoflagellate Reveals a Gene-Rich Protist and a Potential Impact on Gene Expression Due to Bacterial Presence
journal, March 2010
- Moustafa, Ahmed; Evans, Andrew N.; Kulis, David M.
- PLoS ONE, Vol. 5, Issue 3
Predictive toxinology: An initial foray using calculated molecular descriptors to describe toxicity using saxitoxins as a model
journal, December 2007
- Llewellyn, Lyndon E.
- Toxicon, Vol. 50, Issue 7
Structure of saxitoxin in solutions and stereochemistry of dihydrosaxitoxins
journal, February 1981
- Shimizu, Yuzuru; Hsu, Chien-Ping; Genenah, Almoursi
- Journal of the American Chemical Society, Vol. 103, Issue 3
A Putative Gene Cluster from a Lyngbya wollei Bloom that Encodes Paralytic Shellfish Toxin Biosynthesis
journal, February 2011
- Mihali, Troco K.; Carmichael, Wayne W.; Neilan, Brett A.
- PLoS ONE, Vol. 6, Issue 2
Three estuarine Australian dinoflagellates that can produce paralytic shellfish toxins
journal, January 1988
- Hallegraeff, G. M.; Steffensen, D. A.; Wetherbee, R.
- Journal of Plankton Research, Vol. 10, Issue 3
The first evidence of paralytic shellfish toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii, isolated from Brazil
journal, October 1999
- Lagos, Néstor; Onodera, Hideyuki; Zagatto, Pedro Antonio
- Toxicon, Vol. 37, Issue 10
Beyond bilobal: Transferrin homologs having unusual domain architectures
journal, March 2012
- Gaffney, Jean P.; Valentine, Ann M.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1820, Issue 3
A tissue culture assay for direct detection of sodium channel blocking toxins in bacterial culture supernates
journal, April 1992
- Gallacher, Susan; Birkbeck, T. H.
- FEMS Microbiology Letters, Vol. 92, Issue 1
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
journal, November 1991
- Terlau, Heinrich; Heinemann, Stefan H.; Stühmer, Walter
- FEBS Letters, Vol. 293, Issue 1-2
Global transcriptional profiling of the toxic dinoflagellate Alexandrium fundyense using Massively Parallel Signature Sequencing
journal, April 2006
- Erdner, Deana L.; Anderson, Donald M.
- BMC Genomics, Vol. 7, Issue 1
Discovery of Nuclear-Encoded Genes for the Neurotoxin Saxitoxin in Dinoflagellates
journal, May 2011
- Stüken, Anke; Orr, Russell J. S.; Kellmann, Ralf
- PLoS ONE, Vol. 6, Issue 5
Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish
journal, January 1987
- Oshima, Yasukatsu; Hasegawa, Mamiko; Yasumoto, Takeshi
- Toxicon, Vol. 25, Issue 10
Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria
journal, May 2008
- Kellmann, R.; Mihali, T. K.; Jeon, Y. J.
- Applied and Environmental Microbiology, Vol. 74, Issue 13
Production of antibodies and development of highly sensitive formats of enzyme immunoassay for saxitoxin analysis
journal, August 2002
- Micheli, L.; Di Stefano, S.; Moscone, D.
- Analytical and Bioanalytical Chemistry, Vol. 373, Issue 8
Potential impact of a toxic dinoflagellate (Alexandrium excavatum) bloom on survival of fish and crustacean larvae
journal, June 1991
- Robineau, B.; Gagn�, J. A.; Fortier, L.
- Marine Biology, Vol. 108, Issue 2
Structure of saxitoxin
journal, March 1975
- Schantz, E. J.; Ghazarossian, V. E.; Schnoes, H. K.
- Journal of the American Chemical Society, Vol. 97, Issue 5
Ecological functions of tetrodotoxin in a deadly polyclad flatworm
journal, February 2006
- Ritson-Williams, R.; Yotsu-Yamashita, M.; Paul, V. J.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 9
Production and Characterization of Antibodies Against Neosaxitoxin
journal, March 1992
- Chu, Fun S.; Huang, Xuan; Hall, Sherwood
- Journal of AOAC INTERNATIONAL, Vol. 75, Issue 2
Specific toxicity of paralytic shellfish poisons
journal, November 1981
- Genenah, Almoursi A.; Shimizu, Yuzuru
- Journal of Agricultural and Food Chemistry, Vol. 29, Issue 6
Neurotoxic cyanobacterial toxins
journal, October 2010
- Aráoz, Rómulo; Molgó, Jordi; Tandeau de Marsac, Nicole
- Toxicon, Vol. 56, Issue 5
NaChBac: The Long Lost Sodium Channel Ancestor
journal, August 2011
- Charalambous, Kalypso; Wallace, B. A.
- Biochemistry, Vol. 50, Issue 32
Analysis of paralytic shellfish poisoning toxin congeners by a sodium channel receptor binding assay
journal, July 2004
- Usup, Gires; Leaw, Chui-Pin; Cheah, Mei-Yee
- Toxicon, Vol. 44, Issue 1
Investigations into matrix components affecting the performance of the official bioassay reference method for quantitation of paralytic shellfish poisoning toxins in oysters
journal, February 2012
- Turner, Andrew D.; Dhanji-Rapkova, Monika; Algoet, Myriam
- Toxicon, Vol. 59, Issue 2
A Fluorimetric Method Based on Changes in Membrane Potential for Screening Paralytic Shellfish Toxins in Mussels
journal, February 2001
- Louzao, M. C.; Vieytes, M. R.; Baptista de Sousa, J. M. V.
- Analytical Biochemistry, Vol. 289, Issue 2
Verification and quantification of saxitoxin from algal samples using fast and validated hydrophilic interaction liquid chromatography–tandem mass spectrometry method
journal, January 2012
- Halme, Mia; Rapinoja, Marja-Leena; Karjalainen, Maaret
- Journal of Chromatography B, Vol. 880
Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve.
journal, August 1984
- Strichartz, G.
- Journal of General Physiology, Vol. 84, Issue 2
Evolution of Saxitoxin Synthesis in Cyanobacteria and Dinoflagellates
journal, October 2012
- Hackett, Jeremiah D.; Wisecaver, Jennifer H.; Brosnahan, Michael L.
- Molecular Biology and Evolution, Vol. 30, Issue 1
The sodium channel from rat brain. Purification and subunit composition.
journal, February 1984
- Hartshorne, R. P.; Catterall, W. A.
- Journal of Biological Chemistry, Vol. 259, Issue 3
The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.
journal, October 1994
- Dancis, A.; Haile, D.; Yuan, D. S.
- Journal of Biological Chemistry, Vol. 269, Issue 41
Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin.
journal, July 1995
- Morabito, M. A.; Moczydlowski, E.
- Proceedings of the National Academy of Sciences, Vol. 92, Issue 14
Solid-Phase Radioreceptor Assay for Paralytic Shellfish Toxins
journal, May 1993
- Vieytes, M. R.; Cabado, A. G.; Alfonso, A.
- Analytical Biochemistry, Vol. 211, Issue 1
Tetrazolium-Based Cell Bioassay for Neurotoxins Active on Voltage-Sensitive Sodium Channels: Semiautomated Assay for Saxitoxins, Brevetoxins, and Ciguatoxins
journal, October 1993
- Manger, R. L.; Leja, L. S.; Lee, S. Y.
- Analytical Biochemistry, Vol. 214, Issue 1
A Fluorimetric Method Based on Changes in Membrane Potential for Screening Paralytic Shellfish Toxins in Mussels
journal, February 2001
- Louzao, M. C.; Vieytes, M. R.; Baptista de Sousa, J. M. V.
- Analytical Biochemistry, Vol. 289, Issue 2
Detection of Loop-Mediated Isothermal Amplification Reaction by Turbidity Derived from Magnesium Pyrophosphate Formation
journal, November 2001
- Mori, Yasuyoshi; Nagamine, Kentaro; Tomita, Norihiro
- Biochemical and Biophysical Research Communications, Vol. 289, Issue 1
Production of antibodies and development of highly sensitive formats of enzyme immunoassay for saxitoxin analysis
journal, August 2002
- Micheli, L.; Di Stefano, S.; Moscone, D.
- Analytical and Bioanalytical Chemistry, Vol. 373, Issue 8
Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins
journal, January 2010
- Humpage, A. R.; Magalhaes, V. F.; Froscio, S. M.
- Analytical and Bioanalytical Chemistry, Vol. 397, Issue 5
A new simple screening method for the detection of paralytic shellfish poisoning toxins
journal, September 2012
- Cheng, Jinping; Pi, Shuaishuai; Ye, Shufeng
- Chinese Journal of Oceanology and Limnology, Vol. 30, Issue 5
Induction of toxin production in dinoflagellates: the grazer makes a difference
journal, February 2008
- Bergkvist, Johanna; Selander, Erik; Pavia, Henrik
- Oecologia, Vol. 156, Issue 1
A structural perspective on copper uptake in eukaryotes
journal, January 2007
- De Feo, Christopher J.; Aller, Stephen G.; Unger, Vinzenz M.
- BioMetals, Vol. 20, Issue 3-4
A competitive displacement assay to detect saxitoxin and tetrodotoxin
journal, August 1984
- Davio, Stephen R.; Fontelo, Paulito A.
- Analytical Biochemistry, Vol. 141, Issue 1
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II
journal, December 1989
- Noda, Masaharu; Suzuki, Harukazu; Numa, Shosaku
- FEBS Letters, Vol. 259, Issue 1
Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana)
journal, January 1991
- Mahar, Janice; Lukács, Gergely L.; Li, Li
- Toxicon, Vol. 29, Issue 1
Paralytic shellfish poison (saxitoxin family) bioassays: Automated endpoint determination and standardization of the in vitro tissue culture bioassay, and comparison with the standard mouse bioassay
journal, October 1992
- Jellett, Joanne F.; Marks, Linda J.; Stewart, James E.
- Toxicon, Vol. 30, Issue 10
Bioaccumulation of paralytic shellfish poisoning (PSP) toxins from the cyanobacterium Anabaena circinalis by the freshwater mussel Alathyria condola
journal, May 1995
- Negri, Andrew P.; Jones, Gary J.
- Toxicon, Vol. 33, Issue 5
A tissue culture assay for direct detection of sodium channel blocking toxins in bacterial culture supernates
journal, April 1992
- Gallacher, S.
- FEMS Microbiology Letters, Vol. 92, Issue 1
Beyond bilobal: Transferrin homologs having unusual domain architectures
journal, March 2012
- Gaffney, Jean P.; Valentine, Ann M.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1820, Issue 3
Toxicity of Alexandrium lusitanicum to gastropod larvae is not caused by paralytic-shellfish-poisoning toxins
journal, August 2008
- Juhl, A. R.; Martins, C. A.; Anderson, D. M.
- Harmful Algae, Vol. 7, Issue 5
Saxitoxin monitoring in three species of Florida puffer fish
journal, January 2009
- Abbott, Jay P.; Flewelling, Leanne J.; Landsberg, Jan H.
- Harmful Algae, Vol. 8, Issue 2
A multiplex qPCR targeting hepato- and neurotoxigenic cyanobacteria of global significance
journal, March 2012
- Al-Tebrineh, Jamal; Pearson, Leanne A.; Yasar, Serhat A.
- Harmful Algae, Vol. 15
Toxin content and toxic effects of the dinoflagellate Gyrodinium corsicum (Paulmier) on the ingestion and survival rates of the copepods Acartia grani and Euterpina acutifrons
journal, September 2005
- da Costa, Rauquírio Marinho; Franco, José; Cacho, Emiliano
- Journal of Experimental Marine Biology and Ecology, Vol. 322, Issue 2
Biological control of harmful algal blooms: A modelling study
journal, July 2006
- Solé, Jordi; Estrada, Marta; Garcia-Ladona, Emilio
- Journal of Marine Systems, Vol. 61, Issue 3-4
Voltage-gated ion channels and gating modifier toxins
journal, February 2007
- Catterall, William A.; Cestèle, Sandrine; Yarov-Yarovoy, Vladimir
- Toxicon, Vol. 49, Issue 2
Neurotoxic cyanobacterial toxins
journal, October 2010
- Aráoz, Rómulo; Molgó, Jordi; Tandeau de Marsac, Nicole
- Toxicon, Vol. 56, Issue 5
Paralytic shellfish poisoning: Seafood safety and human health perspectives
journal, August 2010
- Etheridge, Stacey M.
- Toxicon, Vol. 56, Issue 2
Investigations into matrix components affecting the performance of the official bioassay reference method for quantitation of paralytic shellfish poisoning toxins in oysters
journal, February 2012
- Turner, Andrew D.; Dhanji-Rapkova, Monika; Algoet, Myriam
- Toxicon, Vol. 59, Issue 2
PSP toxins from Aphanizomenon flos-aquae (cyanobacteria) collected in the Crestuma-Lever reservoir (Douro river, northern Portugal)
journal, June 2001
- Ferreira, Filipa M. B.; Soler, José M. Franco; Fidalgo, Maria Leonor
- Toxicon, Vol. 39, Issue 6
A rapid and sensitive assay for paralytic shellfish poison (PSP) toxins using mouse brain synaptoneurosomes
journal, June 2002
- Nicholson, Russell A.; Li, Guo Hua; Buenaventura, Enrico
- Toxicon, Vol. 40, Issue 6
Development and preliminary validation of a microtiter plate-based receptor binding assay for paralytic shellfish poisoning toxins
journal, May 1997
- Doucette, Gregory J.; Logan, Margaret M.; Ramsdell, John S.
- Toxicon, Vol. 35, Issue 5
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
journal, September 2000
- Cestèle, S.
- Biochimie, Vol. 82, Issue 9-10
Polyketides from dinoflagellates: origins, pharmacology and biosynthesis
journal, October 1999
- Rein, Kathleen S.; Borrone, James
- Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Vol. 124, Issue 2
Expression of Saxiphilin in Insect Cells and Localization of the Saxitoxin-Binding Site to the C-Terminal Domain Homologous to the C-Lobe of Transferrins
journal, October 1995
- Morabito, Maria A.; Llewellyn, Lyndon E.; Moczydlowski, Edward G.
- Biochemistry, Vol. 34, Issue 40
Characterization of Saxitoxin Binding to Saxiphilin, a Relative of the Transferrin Family That Displays pH-Dependent Ligand Binding
journal, October 1994
- Llewellyn, Lyndon E.; Moczydlowski, Edward G.
- Biochemistry, Vol. 33, Issue 40
The Purification and Characterization of the Poison Produced by Gonyaulax catenella in Axenic Culture *
journal, April 1966
- Schantz, Edward J.; Lynch, Joseph M.; Vayvada, George
- Biochemistry, Vol. 5, Issue 4
NaChBac: The Long Lost Sodium Channel Ancestor
journal, August 2011
- Charalambous, Kalypso; Wallace, B. A.
- Biochemistry, Vol. 50, Issue 32
Inhibition of Copper Uptake in Yeast Reveals the Copper Transporter Ctr1p As a Potential Molecular Target of Saxitoxin
journal, February 2012
- Cusick, Kathleen D.; Minkin, Steven C.; Dodani, Sheel C.
- Environmental Science & Technology, Vol. 46, Issue 5
Structure of saxitoxin in solutions and stereochemistry of dihydrosaxitoxins
journal, February 1981
- Shimizu, Yuzuru; Hsu, Chien-Ping; Genenah, Almoursi
- Journal of the American Chemical Society, Vol. 103, Issue 3
The pKa's of saxitoxin
journal, November 1980
- Rogers, R. Scott; Rapoport, Henry
- Journal of the American Chemical Society, Vol. 102, Issue 24
Specific toxicity of paralytic shellfish poisons
journal, November 1981
- Genenah, Almoursi A.; Shimizu, Yuzuru
- Journal of Agricultural and Food Chemistry, Vol. 29, Issue 6
Direct Competitive Enzyme-Linked Immunosorbent Assay for Saxitoxin and Neosaxitoxin
journal, January 1996
- Huang, Xuan; Hsu, Kuo-Hui; Chu, Fun S.
- Journal of Agricultural and Food Chemistry, Vol. 44, Issue 4
A Fluorimetric Microplate Assay for Detection and Quantitation of Toxins Causing Paralytic Shellfish Poisoning
journal, April 2003
- Louzao, Maria Carmen; Vieytes, Mercedes Rodriguez; Cabado, Ana Garcia
- Chemical Research in Toxicology, Vol. 16, Issue 4
Purification and characterization of sulfotransferase specific to O-22 of 11-hydroxy saxitoxin from the toxic dinoflagellate Gymnodinium catenatum (dinophyceae)
journal, June 2002
- Yoshida, Takashi; Sako, Yoshihiko; Uchida, Aritsune
- Fisheries Science, Vol. 68, Issue 3
Ecological functions of tetrodotoxin in a deadly polyclad flatworm
journal, February 2006
- Ritson-Williams, R.; Yotsu-Yamashita, M.; Paul, V. J.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 9
Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture
journal, February 2006
- Aller, S. G.; Unger, V. M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 10
DNA probes, targeting large sub‐unit rRNA, for the rapid identification of the paralytic shellfish poison producing dinoflagellate, Gymnodinium catenatum
journal, December 2007
- Rhodes, Lesley; Smith, Kirsty; De Salas, Miguel
- New Zealand Journal of Marine and Freshwater Research, Vol. 41, Issue 4
Production and characterization of antibodies against neosaxitoxin utilizing a novel immunogen Synthesis procedure
journal, January 1995
- Bürk, Christine; Usleber, Ewald; Dietrich, Richard
- Food and Agricultural Immunology, Vol. 7, Issue 4
Development of ELISAs for detecting domoic acid, okadaic acid, and saxitoxin and their applicability for the detection of marine toxins in samples collected in Belgium
journal, June 2010
- Dubois, M.; Demoulin, L.; Charlier, C.
- Food Additives & Contaminants: Part A, Vol. 27, Issue 6
Saxitoxin Is a Gating Modifier of hERG K+ Channels
journal, May 2003
- Wang, Jixin; Salata, Joseph J.; Bennett, Paul B.
- The Journal of General Physiology, Vol. 121, Issue 6
Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve.
journal, August 1984
- Strichartz, G.
- Journal of General Physiology, Vol. 84, Issue 2
Extraordinary Conservation, Gene Loss, and Positive Selection in the Evolution of an Ancient Neurotoxin
journal, November 2010
- Murray, Shauna A.; Mihali, Troco K.; Neilan, Brett A.
- Molecular Biology and Evolution, Vol. 28, Issue 3
Dozens of Toxin-Related Genes Are Expressed in a Nontoxic Strain of the Dinoflagellate Heterocapsa circularisquama
journal, January 2012
- Salcedo, Tovah; Upadhyay, Ravi J.; Nagasaki, Keizo
- Molecular Biology and Evolution, Vol. 29, Issue 6
Evolution of Saxitoxin Synthesis in Cyanobacteria and Dinoflagellates
journal, October 2012
- Hackett, Jeremiah D.; Wisecaver, Jennifer H.; Brosnahan, Michael L.
- Molecular Biology and Evolution, Vol. 30, Issue 1
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability
journal, January 1993
- Strong, M.; Chandy, K. G.; Gutman, G. A.
- Molecular Biology and Evolution, Vol. 10, Issue 1, 221–242
Three estuarine Australian dinoflagellates that can produce paralytic shellfish toxins
journal, January 1988
- Hallegraeff, G. M.; Steffensen, D. A.; Wetherbee, R.
- Journal of Plankton Research, Vol. 10, Issue 3
Notes on Alexandrium population dynamics
journal, January 1997
- Wyatt, Tim; Jenkinson, Ian R.
- Journal of Plankton Research, Vol. 19, Issue 5
Copepods induce paralytic shellfish toxin production in marine dinoflagellates
journal, April 2006
- Selander, Erik; Thor, Peter; Toth, Gunilla
- Proceedings of the Royal Society B: Biological Sciences, Vol. 273, Issue 1594
Regulated Copper Uptake in Chlamydomonas reinhardtii in Response to Copper Availability
journal, October 1996
- Hill, K. L.; Hassett, R.; Kosman, D.
- Plant Physiology, Vol. 112, Issue 2
Direct enzyme immunoassay in microtitration plate and test strip format for the detection of saxitoxin in shellfish
journal, December 1991
- Usleber, E.; Schneider, E.; Terplan, G.
- Letters in Applied Microbiology, Vol. 13, Issue 6
Intracellular Localization of Saxitoxins in the Dinoflagellate Gonyaulax Tamarensis1
journal, March 1988
- Anderson, Donald M.; Cheng, Toni Po-On
- Journal of Phycology, Vol. 24, Issue 1
Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon.
journal, February 1982
- Kao, C. Y.; Walker, S. E.
- The Journal of Physiology, Vol. 323, Issue 1
Saxitoxin Blocks L-Type I Ca
journal, October 2003
- Su, Zhi; Sheets, Michael; Ishida, Hideyuki
- Journal of Pharmacology and Experimental Therapeutics, Vol. 308, Issue 1
sxtA -Based Quantitative Molecular Assay To Identify Saxitoxin-Producing Harmful Algal Blooms in Marine Waters
journal, August 2011
- Murray, Shauna A.; Wiese, Maria; Stüken, Anke
- Applied and Environmental Microbiology, Vol. 77, Issue 19
Examination of the Seasonal Dynamics of the Toxic Dinoflagellate Alexandrium catenella at Redondo Beach, California, by Quantitative PCR
journal, November 2011
- Garneau, Marie-Ève; Schnetzer, Astrid; Countway, Peter D.
- Applied and Environmental Microbiology, Vol. 77, Issue 21
Evidence for paralytic shellfish poisons in the freshwater cyanobacterium Lyngbya wollei (Farlow ex Gomont) comb. nov
journal, August 1997
- Carmichael, W. W.; Evans, W. R.; Yin, Q. Q.
- Applied and Environmental Microbiology, Vol. 63, Issue 8
MICROALGAL METABOLITES: A New Perspective
journal, October 1996
- Shimizu, Yuzuru
- Annual Review of Microbiology, Vol. 50, Issue 1
Bioterrorism: Toxins as Weapons
journal, April 2012
- Anderson, Peter D.
- Journal of Pharmacy Practice, Vol. 25, Issue 2
Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5
journal, January 2009
- Mihali, Troco K.; Kellmann, Ralf; Neilan, Brett A.
- BMC Biochemistry, Vol. 10, Issue 1
Studies on paralytic shellfish poisoning in tropical waters. Part IV. Structures of two paralytic shellfish toxins, gonyautoxins V and VI, isolated from a tropical dinoflagellate, Pyrodinium bahamense var. compressa.
journal, January 1982
- Harada, Takako; Oshima, Yasukatsu; Yasumoto, Takeshi
- Agricultural and Biological Chemistry, Vol. 46, Issue 7
From Stop to Start: Tandem Gene Arrangement, Copy Number and Trans-Splicing Sites in the Dinoflagellate Amphidinium carterae
journal, August 2008
- Bachvaroff, Tsvetan R.; Place, Allen R.
- PLoS ONE, Vol. 3, Issue 8
Origin of Saxitoxin Biosynthetic Genes in Cyanobacteria
journal, June 2009
- Moustafa, Ahmed; Loram, Jeannette E.; Hackett, Jeremiah D.
- PLoS ONE, Vol. 4, Issue 6
Transcriptome Profiling of a Toxic Dinoflagellate Reveals a Gene-Rich Protist and a Potential Impact on Gene Expression Due to Bacterial Presence
journal, March 2010
- Moustafa, Ahmed; Evans, Andrew N.; Kulis, David M.
- PLoS ONE, Vol. 5, Issue 3
A Putative Gene Cluster from a Lyngbya wollei Bloom that Encodes Paralytic Shellfish Toxin Biosynthesis
journal, February 2011
- Mihali, Troco K.; Carmichael, Wayne W.; Neilan, Brett A.
- PLoS ONE, Vol. 6, Issue 2
Discovery of Nuclear-Encoded Genes for the Neurotoxin Saxitoxin in Dinoflagellates
journal, May 2011
- Stüken, Anke; Orr, Russell J. S.; Kellmann, Ralf
- PLoS ONE, Vol. 6, Issue 5
Neuroecology, Chemical Defense, and the Keystone Species Concept
journal, December 2007
- Zimmer, Richard K.; Ferrer, Ryan P.
- The Biological Bulletin, Vol. 213, Issue 3
Copepod grazing selection and particle discrimination on the basis of PSP toxin content
journal, January 1999
- Teegarden, Gj
- Marine Ecology Progress Series, Vol. 181
Short-term and long-term effects of the toxic dinoflagellate Alexandrium minutum on the copepod Acartia clausi
journal, January 2000
- Frangópulos, M.; Guisande, C.; Maneiro, I.
- Marine Ecology Progress Series, Vol. 203
New Insights into Cardiac and Brain Sodium Channels Modulation by Beta Blockers
journal, January 2011
- Chahine, Mohamed
- Frontiers in Pharmacology, Vol. 2
Non-Traditional Vectors for Paralytic Shellfish Poisoning
journal, June 2008
- Deeds, Jonathan; Landsberg, Jan; Etheridge, Stacey
- Marine Drugs, Vol. 6, Issue 2
Development and Application of an Enzyme Immunoassay Based on a Monoclonal Antibody against Gonyautoxin Components of Paralytic Shellfish Poisoning Toxins
journal, August 2002
- Kawatsu, Kentaro; Hamano, Yonekazu; Sugiyama, Akira
- Journal of Food Protection, Vol. 65, Issue 8
Toxic marine phytoplankton, zooplankton grazers, and pelagic food webs
journal, July 1997
- Turner, Jefferson T.; Tester, Patricia A.
- Limnology and Oceanography, Vol. 42, Issue 5part2
Refinement of AOAC Official MethodSM 2005.06 Liquid Chromatography-Fluorescence Detection Method to Improve Performance Characteristics for the Determination of Paralytic Shellfish Toxins in King and Queen Scallops
journal, January 2012
- Turner, Andrew D.; Hatfield, Robert G.
- Journal of AOAC INTERNATIONAL, Vol. 95, Issue 1
Determination of Paralytic Shellfish Toxins in Shellfish by Receptor Binding Assay: Collaborative Study
journal, May 2012
- Van Dolah, Frances M.; Fire, Spencer E.; Leighfield, Tod A.
- Journal of AOAC INTERNATIONAL, Vol. 95, Issue 3
Works referencing / citing this record:
Marine natural products
journal, January 2020
- Carroll, Anthony R.; Copp, Brent R.; Davis, Rohan A.
- Natural Product Reports, Vol. 37, Issue 2
Biosynthetic route towards saxitoxin and shunt pathway
journal, February 2016
- Tsuchiya, Shigeki; Cho, Yuko; Konoki, Keiichi
- Scientific Reports, Vol. 6, Issue 1
One‐Step Synthesis of 2,5‐Diaminoimidazoles and Total Synthesis of Methylglyoxal‐Derived Imidazolium Crosslink (MODIC)
journal, November 2019
- Sabbasani, Venkata R.; Wang, Kung‐Pern; Streeter, Matthew D.
- Angewandte Chemie, Vol. 131, Issue 52
In silico prediction of the secretome from the invasive neurotoxic marine dinoflagellate Alexandrium catenella
journal, May 2019
- Chetouhi, Cherif; Laabir, Mohammed; Masseret, Estelle
- Environmental Microbiology Reports, Vol. 11, Issue 4
Development of an Electrochemical Biosensor for the Rapid Detection of Saxitoxin Based on Air Stable Lipid Films with Incorporated Anti-STX Using Graphene Electrodes
journal, December 2016
- Bratakou, Spyridoula; Nikoleli, Georgia-Paraskevi; Siontorou, Christina G.
- Electroanalysis, Vol. 29, Issue 4
Saxitoxin and tetrodotoxin bioavailability increases in future oceans
journal, October 2019
- Roggatz, C. C.; Fletcher, N.; Benoit, D. M.
- Nature Climate Change, Vol. 9, Issue 11
Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels
journal, October 2017
- Durán-Riveroll, Lorena; Cembella, Allan
- Marine Drugs, Vol. 15, Issue 10
Occurrence and diversity of cyanotoxins in Greek lakes
journal, December 2018
- Christophoridis, Christophoros; Zervou, Sevasti-Kiriaki; Manolidi, Korina
- Scientific Reports, Vol. 8, Issue 1
The invasive sea slug Pleurobranchaea maculata is a vector of two potent neurotoxins in coasts of Argentina
journal, May 2019
- Farias, Nahuel E.; Goya, Alejandra B.; Schwindt, Evangelina
- Marine Biology, Vol. 166, Issue 7
Evolutionary processes and cellular functions underlying divergence in Alexandrium minutum
journal, September 2016
- Le Gac, Mickael; Metegnier, Gabriel; Chomérat, Nicolas
- Molecular Ecology, Vol. 25, Issue 20
The gene-rich genome of the scallop Pecten maximus.
text, January 2020
- Kenny, Nathan J.; McCarthy, Shane; Dudchenko, Olga
- Apollo - University of Cambridge Repository
The Gene-Rich Genome of the Scallop Pecten maximus
posted_content, January 2020
- Kenny, Nathan J.; McCarthy, Shane A.; Dudchenko, Olga
- bioRxiv
One‐Step Synthesis of 2,5‐Diaminoimidazoles and Total Synthesis of Methylglyoxal‐Derived Imidazolium Crosslink (MODIC)
journal, December 2019
- Sabbasani, Venkata R.; Wang, Kung‐Pern; Streeter, Matthew D.
- Angewandte Chemie International Edition, Vol. 58, Issue 52
Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates
journal, December 2017
- Assunção, Joana; Guedes, A.; Malcata, F.
- Marine Drugs, Vol. 15, Issue 12
Analysis of the genomic basis of functional diversity in dinoflagellates using a transcriptome-based sequence similarity network
journal, May 2018
- Meng, Arnaud; Corre, Erwan; Probert, Ian
- Molecular Ecology, Vol. 27, Issue 10
iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium catenella at Different Stages of Toxin Biosynthesis during the Cell Cycle
journal, December 2018
- Zhang, Shu-Fei; Zhang, Yong; Lin, Lin
- Marine Drugs, Vol. 16, Issue 12
Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)
journal, January 2014
- Tsuchiya, Shigeki; Cho, Yuko; Konoki, Keiichi
- Org. Biomol. Chem., Vol. 12, Issue 19
Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways
journal, January 2019
- Cullen, Alescia; Pearson, Leanne A.; Mazmouz, Rabia
- Natural Product Reports, Vol. 36, Issue 8
Chemical ecology of marine plankton
journal, January 2016
- Schwartz, Emily R.; Poulin, Remington X.; Mojib, Nazia
- Natural Product Reports, Vol. 33, Issue 7
Saxitoxin
journal, April 2014
- Thottumkara, Arun P.; Parsons, William H.; Du Bois, J.
- Angewandte Chemie International Edition, Vol. 53, Issue 23
Rapid screening fluorescence method applied to detection and quantitation of paralytic shellfish toxins in invertebrate marine vectors
journal, May 2019
- Masias, Daisy; Gómez, Kelly; Contreras, Cristóbal
- Food Additives & Contaminants: Part A, Vol. 36, Issue 7
A sensing smartphone and its portable accessory for on-site rapid biochemical detection of marine toxins
journal, January 2016
- Fang, Jiaru; Qiu, Xianxin; Wan, Zijian
- Analytical Methods, Vol. 8, Issue 38
Marine Natural Products
journal, May 2004
- Blunt, John W.; Copp, Brent R.; Munro, Murray H. G.
- ChemInform, Vol. 35, Issue 20
The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review
journal, September 2019
- Du, Xingde; Liu, Haohao; Yuan, Le
- Toxins, Vol. 11, Issue 9
Saxitoxin-Producing cyanobacteria in Lake Baikal
journal, March 2015
- Belykh, O. I.; Gladkikh, A. S.; Sorokovikova, E. G.
- Contemporary Problems of Ecology, Vol. 8, Issue 2
The gene-rich genome of the scallop Pecten maximus
journal, April 2020
- Kenny, Nathan J.; McCarthy, Shane A.; Dudchenko, Olga
- GigaScience, Vol. 9, Issue 5
Marine chemical ecology in benthic environments
journal, January 2019
- Puglisi, Melany P.; Sneed, Jennifer M.; Ritson-Williams, Raphael
- Natural Product Reports, Vol. 36, Issue 3
Experimental exposure of the mussel Mytilus platensis (d’Orbigny, 1842) to the dinoflagellate Alexandrium catenella from Argentine Patagonia
journal, February 2020
- Gracia Villalobos, Leilén L.; Tobke, Jésica L.; Montoya, Nora G.
- Ecotoxicology, Vol. 29, Issue 2
Analysis of the Genomic Basis of Functional Diversity in Dinoflagellates using a Transcriptome-Based Sequence Similarity Network
posted_content, October 2017
- Meng, Arnaud; Corre, Erwan; Probert, Ian
- Molecular Ecology
Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
journal, December 2019
- Adachi, Kanna; Ishizuka, Hayate; Odagi, Minami
- Marine Drugs, Vol. 18, Issue 1
Saxitoxin
journal, April 2014
- Thottumkara, Arun P.; Parsons, William H.; Du Bois, J.
- Angewandte Chemie, Vol. 126, Issue 23
First Report on the Occurrence of Tetrodotoxins in Bivalve Mollusks in The Netherlands
journal, November 2018
- Gerssen, Arjen; Bovee, Toine; Klijnstra, Mirjam
- Toxins, Vol. 10, Issue 11
Insights in the determination of saxitoxin with fluorogenic crown ethers in water
journal, January 2018
- Müller, Bernhard J.; Mistlberger, Günter; Klimant, Ingo
- Monatshefte für Chemie - Chemical Monthly, Vol. 149, Issue 3
Mercury, selenium and fish oils in marine food webs and implications for human health
journal, September 2015
- Gribble, Matthew O.; Karimi, Roxanne; Feingold, Beth J.
- Journal of the Marine Biological Association of the United Kingdom, Vol. 96, Issue 1
Occurrence and diversity of cyanotoxins in Greek lakes
journal, December 2018
- Christophoridis, Christophoros; Zervou, Sevasti-Kiriaki; Manolidi, Korina
- Scientific Reports, Vol. 8, Issue 1
Biosynthetic route towards saxitoxin and shunt pathway
journal, February 2016
- Tsuchiya, Shigeki; Cho, Yuko; Konoki, Keiichi
- Scientific Reports, Vol. 6, Issue 1
iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium catenella and Its Non-toxigenic Mutant Exposed to a Cell Cycle Inhibitor Colchicine
journal, April 2018
- Zhang, Shu-Fei; Zhang, Yong; Lin, Lin
- Frontiers in Microbiology, Vol. 9
Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action
journal, August 2017
- Mayer, Alejandro; Rodríguez, Abimael; Taglialatela-Scafati, Orazio
- Marine Drugs, Vol. 15, Issue 9
Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels
journal, October 2017
- Durán-Riveroll, Lorena; Cembella, Allan
- Marine Drugs, Vol. 15, Issue 10
Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates
journal, December 2017
- Assunção, Joana; Guedes, A.; Malcata, F.
- Marine Drugs, Vol. 15, Issue 12
Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective
journal, February 2020
- Akbar, Muhamad Afiq; Mohd Yusof, Nurul Yuziana; Tahir, Noor Idayu
- Marine Drugs, Vol. 18, Issue 2
Metagenomic Sequencing Identifies Highly Diverse Assemblages of Dinoflagellate Cysts in Sediments from Ships’ Ballast Tanks
journal, August 2019
- Shang,
- Microorganisms, Vol. 7, Issue 8
A Systematic Literature Review for Evidence of Aphanizomenon flos-aquae Toxigenicity in Recreational Waters and Toxicity of Dietary Supplements: 2000–2017
journal, June 2018
- Lyon-Colbert, Amber; Su, Shelley; Cude, Curtis
- Toxins, Vol. 10, Issue 7
First Report on the Occurrence of Tetrodotoxins in Bivalve Mollusks in The Netherlands
journal, November 2018
- Gerssen, Arjen; Bovee, Toine; Klijnstra, Mirjam
- Toxins, Vol. 10, Issue 11
Contrasting Toxin Selectivity between the Marine Pufferfish Takifugu pardalis and the Freshwater Pufferfish Pao suvattii
journal, August 2019
- Gao, Wei; Kanahara, Yoko; Yamada, Misako
- Toxins, Vol. 11, Issue 8
The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review
journal, September 2019
- Du, Xingde; Liu, Haohao; Yuan, Le
- Toxins, Vol. 11, Issue 9