Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study
Abstract
Abstract Objectives To investigate the neuroimaging characteristics of auditory verbal hallucinations (AVHs) in patients with bipolar disorder (BP) experiencing depressive episodes with and without AVHs, and alterations in those characteristics after transcranial direct current stimulation (tDCS). Methods For a baseline pilot study, we recruited 80 patients with BP and depressive status (40 with and 40 without AVHs), and 40 healthy controls (HCs). Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging (fMRI). Voxel‐wise one‐way analysis of covariance (ANCOVA) was conducted to detect intergroup differences in gFCD. In a follow‐up study, the effects of 5 weeks of tDCS augmentation treatment on clinical symptoms and gFCD were assessed in the 40 BP patients with AVHs. Results Compared to HCs, BP patients with and without AVHs exhibited increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, with decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). Only patients with AVHs showed increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). After 5 weeks of tDCS, AVHs were slightly alleviated and gFCD abnormalities in the hippocampus were mildly attenuated. Conclusions Patients with BP and AVHsmore »
- Authors:
-
[1];
- School of Mental Health Jining Medical University Jining China, Psychiatric‐Neuroimaging‐Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China, Psychiatric‐Neuroimaging‐Genetics‐Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China, Department of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan China, MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China
- School of Mental Health Jining Medical University Jining China
- Psychiatric‐Neuroimaging‐Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China
- Psychiatric‐Neuroimaging‐Genetics‐Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China
- Department of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan China, MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China
- Co‐collaboration Laboratory of China and Canada Xiamen Xianyue Hospital and University of Alberta Xiamen China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1615387
- Alternate Identifier(s):
- OSTI ID: 1615388
- Resource Type:
- Published Article
- Journal Name:
- Brain and Behavior (Online)
- Additional Journal Information:
- Journal Name: Brain and Behavior (Online) Journal Volume: 10 Journal Issue: 6; Journal ID: ISSN 2162-3279
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Zhuo, Chuanjun, Ji, Feng, Lin, Xiaodong, Tian, Hongjun, Wang, Lina, Xu, Yong, Wang, Wenqiang, and Jiang, Deguo. Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study. United States: N. p., 2020.
Web. doi:10.1002/brb3.1637.
Zhuo, Chuanjun, Ji, Feng, Lin, Xiaodong, Tian, Hongjun, Wang, Lina, Xu, Yong, Wang, Wenqiang, & Jiang, Deguo. Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study. United States. https://doi.org/10.1002/brb3.1637
Zhuo, Chuanjun, Ji, Feng, Lin, Xiaodong, Tian, Hongjun, Wang, Lina, Xu, Yong, Wang, Wenqiang, and Jiang, Deguo. Sat .
"Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study". United States. https://doi.org/10.1002/brb3.1637.
@article{osti_1615387,
title = {Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study},
author = {Zhuo, Chuanjun and Ji, Feng and Lin, Xiaodong and Tian, Hongjun and Wang, Lina and Xu, Yong and Wang, Wenqiang and Jiang, Deguo},
abstractNote = {Abstract Objectives To investigate the neuroimaging characteristics of auditory verbal hallucinations (AVHs) in patients with bipolar disorder (BP) experiencing depressive episodes with and without AVHs, and alterations in those characteristics after transcranial direct current stimulation (tDCS). Methods For a baseline pilot study, we recruited 80 patients with BP and depressive status (40 with and 40 without AVHs), and 40 healthy controls (HCs). Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging (fMRI). Voxel‐wise one‐way analysis of covariance (ANCOVA) was conducted to detect intergroup differences in gFCD. In a follow‐up study, the effects of 5 weeks of tDCS augmentation treatment on clinical symptoms and gFCD were assessed in the 40 BP patients with AVHs. Results Compared to HCs, BP patients with and without AVHs exhibited increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, with decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). Only patients with AVHs showed increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). After 5 weeks of tDCS, AVHs were slightly alleviated and gFCD abnormalities in the hippocampus were mildly attenuated. Conclusions Patients with BP and AVHs showed disturbances in the brain's communication capacity mainly in the left frontoparietal network, control network, and memory circuitry. Five weeks of tDCS alleviated AVHs slightly, without improving depressive symptoms, and attenuated hippocampal gFCD alterations in these patients.},
doi = {10.1002/brb3.1637},
journal = {Brain and Behavior (Online)},
number = 6,
volume = 10,
place = {United States},
year = {Sat Apr 18 00:00:00 EDT 2020},
month = {Sat Apr 18 00:00:00 EDT 2020}
}
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