Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy
Abstract
How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca’s area/the right Broca’s homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca’s area/the right Broca’s homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated functional connectivity with Broca’s area decreased in the left midtemporal cortex. Furthermore, task-related response decreased in the left mid temporal cortex that overlapped with the region showing a decrease in the structural connectivity. In contrast, the region showing an increase in the structural connectivity through the AF overlapped with the regions showing an increase in task-modulated functional connectivity in the left inferior parietal cortex. These structural and functional changes in the overlapping regions were correlated. The results suggest that the change in the structural connectivity through the left frontal–temporal AF pathway underliesmore »
- Authors:
-
- Massachusetts General Hospital (MGH), Charlestown, MA (United States). Harvard-MIT Program in Health Sciences and Technology (HST) Athinoula A. Martinos Center for Biomedical Imaging; Harvard Univ., Boston, MA (United States). Harvard Medical School (HMS); Kyoto Univ. (Japan). Graduate School of Medicine, Human Brain Research Center and Dept. of Neurology
- Massachusetts General Hospital (MGH), Charlestown, MA (United States). Harvard-MIT Program in Health Sciences and Technology (HST) Athinoula A. Martinos Center for Biomedical Imaging; Harvard Univ., Boston, MA (United States). Harvard Medical School (HMS)
- Harvard Univ., Boston, MA (United States). Harvard Medical School (HMS); Massachusetts General Hospital (MGH), Boston, MA (United States)
- Harvard Univ., Boston, MA (United States). Harvard Medical School (HMS); Massachusetts General Hospital (MGH), Boston, MA (United States). Dept. of Neurology
- Publication Date:
- Research Org.:
- Massachusetts General Hospital (MGH), Boston, MA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH); National Science Foundation (NSF); Uehara Memorial Foundation
- OSTI Identifier:
- 1463084
- Grant/Contract Number:
- SC0008430; R01-NS069696; P41-EB015896; U01-MH093765; T32-EB001680; NFSDMS-1042134
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Human Brain Mapping
- Additional Journal Information:
- Journal Volume: 37; Journal Issue: 12; Journal ID: ISSN 1065-9471
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; Broca's area; freesurfer; function; language; MRI; psychophysiological interaction; reorganization; semantic; structure; tractography
Citation Formats
Takaya, Shigetoshi, Liu, Hesheng, Greve, Douglas N., Tanaka, Naoaki, Leveroni, Catherine, Cole, Andrew J., and Stufflebeam, Steven M. Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy. United States: N. p., 2016.
Web. doi:10.1002/hbm.23319.
Takaya, Shigetoshi, Liu, Hesheng, Greve, Douglas N., Tanaka, Naoaki, Leveroni, Catherine, Cole, Andrew J., & Stufflebeam, Steven M. Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy. United States. https://doi.org/10.1002/hbm.23319
Takaya, Shigetoshi, Liu, Hesheng, Greve, Douglas N., Tanaka, Naoaki, Leveroni, Catherine, Cole, Andrew J., and Stufflebeam, Steven M. Mon .
"Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy". United States. https://doi.org/10.1002/hbm.23319. https://www.osti.gov/servlets/purl/1463084.
@article{osti_1463084,
title = {Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy},
author = {Takaya, Shigetoshi and Liu, Hesheng and Greve, Douglas N. and Tanaka, Naoaki and Leveroni, Catherine and Cole, Andrew J. and Stufflebeam, Steven M.},
abstractNote = {How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca’s area/the right Broca’s homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca’s area/the right Broca’s homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated functional connectivity with Broca’s area decreased in the left midtemporal cortex. Furthermore, task-related response decreased in the left mid temporal cortex that overlapped with the region showing a decrease in the structural connectivity. In contrast, the region showing an increase in the structural connectivity through the AF overlapped with the regions showing an increase in task-modulated functional connectivity in the left inferior parietal cortex. These structural and functional changes in the overlapping regions were correlated. The results suggest that the change in the structural connectivity through the left frontal–temporal AF pathway underlies the altered functional networks between the frontal and temporal cortices during the language-related processing in patients with left TLE. The left frontal–parietal AF pathway might be employed to connect anterior and posterior brain regions during language processing and compensate for the compromised left frontal–temporal AF pathway.},
doi = {10.1002/hbm.23319},
journal = {Human Brain Mapping},
number = 12,
volume = 37,
place = {United States},
year = {Mon Jul 25 00:00:00 EDT 2016},
month = {Mon Jul 25 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
Bilateral inferior frontal language-related activation correlates with verbal recall in patients with left temporal lobe epilepsy and typical language distribution
journal, March 2013
- Sanjuán, Ana; Bustamante, Juan Carlos; García-Porcar, María
- Epilepsy Research, Vol. 104, Issue 1-2
Changes in Language Pathways in Patients with Temporal Lobe Epilepsy: Diffusion Tensor Imaging Analysis of the Uncinate and Arcuate Fasciculi
journal, March 2011
- Kim, Chi Heon; Chung, Chun Kee; Koo, Bang-Bon
- World Neurosurgery, Vol. 75, Issue 3-4
Altered white matter integrity in temporal lobe epilepsy: Association with cognitive and clinical profiles
journal, April 2010
- Riley, Jeffrey D.; Franklin, David L.; Choi, Vicky
- Epilepsia, Vol. 51, Issue 4
Structural connectivity differences in left and right temporal lobe epilepsy
journal, October 2014
- Besson, Pierre; Dinkelacker, Vera; Valabregue, Romain
- NeuroImage, Vol. 100
MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome
journal, July 2004
- Carne, R. P.; O'Brien, T. J.; Kilpatrick, C. J.
- Brain, Vol. 127, Issue 10
Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing
journal, May 2006
- Vigneau, M.; Beaucousin, V.; Hervé, P. Y.
- NeuroImage, Vol. 30, Issue 4
Structural substrates for resting network disruption in temporal lobe epilepsy
journal, June 2012
- Voets, Natalie L.; Beckmann, Christian F.; Cole, David M.
- Brain, Vol. 135, Issue 8
Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy
journal, July 2012
- Concha, L.; Kim, H.; Bernasconi, A.
- Neurology, Vol. 79, Issue 5
Improved picture naming in chronic aphasia after TMS to part of right Broca?s area: An open-protocol study
journal, April 2005
- Naeser, M.; Martin, P.; Nicholas, M.
- Brain and Language, Vol. 93, Issue 1
Functional MRI of phonological and semantic processing in temporal lobe epilepsy
journal, June 2001
- Billingsley, R. L.
- Brain, Vol. 124, Issue 6
Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language
journal, May 2004
- Hickok, Gregory; Poeppel, David
- Cognition, Vol. 92, Issue 1-2
Vulnerability of the frontal-temporal connections in temporal lobe epilepsy
journal, December 2008
- Lin, Jack J.; Riley, Jeffrey D.; Juranek, Jenifer
- Epilepsy Research, Vol. 82, Issue 2-3
Hemispheric asymmetries in language-related pathways: A combined functional MRI and tractography study
journal, August 2006
- Powell, H. W. Robert; Parker, Geoff J. M.; Alexander, Daniel C.
- NeuroImage, Vol. 32, Issue 1
Characterizing Functional Integrity: Intraindividual Brain Signal Variability Predicts Memory Performance in Patients with Medial Temporal Lobe Epilepsy
journal, June 2013
- Protzner, A. B.; Kovacevic, N.; Cohn, M.
- Journal of Neuroscience, Vol. 33, Issue 23
Is Amygdalohippocampectomy Really Selective in Medial Temporal Lobe Epilepsy? A Study Using Positron Emission Tomography with 18Fluorodeoxyglucose
journal, June 2001
- Dupont, Sophie; Croizé, Anne-Claire; Semah, Franck
- Epilepsia, Vol. 42, Issue 6
White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis
journal, August 2013
- Perlaki, Gabor; Horvath, Reka; Orsi, Gergely
- Brain and Cognition, Vol. 82, Issue 3
Reorganization of language-related neuronal networks in patients with left temporal lobe epilepsy - an fMRI study
journal, April 2005
- Brazdil, M.; Chlebus, P.; Mikl, M.
- European Journal of Neurology, Vol. 12, Issue 4
Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain
journal, September 2015
- Takaya, Shigetoshi; Kuperberg, Gina R.; Liu, Hesheng
- Frontiers in Neuroanatomy, Vol. 9
Segmentation of Subcomponents within the Superior Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study
journal, December 2004
- Makris, Nikos; Kennedy, David N.; McInerney, Sean
- Cerebral Cortex, Vol. 15, Issue 6
White matter microstructure complements morphometry for predicting verbal memory in epilepsy
journal, September 2014
- McDonald, Carrie R.; Leyden, Kelly M.; Hagler, Donald J.
- Cortex, Vol. 58
Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
journal, September 2008
- Liegeois, F.
- Brain and Language, Vol. 106, Issue 3
Changes in extratemporal integrity and cognition in temporal lobe epilepsy: A diffusion tensor imaging study
journal, January 2010
- Lang, Sen-yang; Hong, Lu; Lin, Ma
- Neurology India, Vol. 58, Issue 6
Extensive Cortical Rewiring after Brain Injury
journal, November 2005
- Dancause, N.
- Journal of Neuroscience, Vol. 25, Issue 44
Accurate and robust brain image alignment using boundary-based registration
journal, October 2009
- Greve, Douglas N.; Fischl, Bruce
- NeuroImage, Vol. 48, Issue 1
Productive and perceptive language reorganization in temporal lobe epilepsy
journal, February 2005
- Thivard, Lionel; Hombrouck, Jérémie; Tézenas du Montcel, Sophie
- NeuroImage, Vol. 24, Issue 3
Symmetries in human brain language pathways correlate with verbal recall
journal, October 2007
- Catani, M.; Allin, M. P. G.; Husain, M.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 43
High-resolution intersubject averaging and a coordinate system for the cortical surface
journal, January 1999
- Fischl, Bruce; Sereno, Martin I.; Tootell, Roger B. H.
- Human Brain Mapping, Vol. 8, Issue 4
Where Is the Semantic System? A Critical Review and Meta-Analysis of 120 Functional Neuroimaging Studies
journal, March 2009
- Binder, Jeffrey R.; Desai, Rutvik H.; Graves, William W.
- Cerebral Cortex, Vol. 19, Issue 12
Smoothing and cluster thresholding for cortical surface-based group analysis of fMRI data
journal, December 2006
- Hagler, Donald J.; Saygin, Ayse Pinar; Sereno, Martin I.
- NeuroImage, Vol. 33, Issue 4
Network specific change in white matter integrity in mesial temporal lobe epilepsy
journal, February 2016
- Imamura, Hisaji; Matsumoto, Riki; Takaya, Shigetoshi
- Epilepsy Research, Vol. 120
Beyond the arcuate fasciculus: consensus and controversy in the connectional anatomy of language
journal, October 2012
- Dick, A. S.; Tremblay, P.
- Brain, Vol. 135, Issue 12
The Neural Organization of Semantic Control: TMS Evidence for a Distributed Network in Left Inferior Frontal and Posterior Middle Temporal Gyrus
journal, September 2010
- Whitney, C.; Kirk, M.; O'Sullivan, J.
- Cerebral Cortex, Vol. 21, Issue 5
Where do you know what you know? The representation of semantic knowledge in the human brain
journal, December 2007
- Patterson, Karalyn; Nestor, Peter J.; Rogers, Timothy T.
- Nature Reviews Neuroscience, Vol. 8, Issue 12
Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy
journal, October 2008
- McDonald, C. R.; Ahmadi, M. E.; Hagler, D. J.
- Neurology, Vol. 71, Issue 23
Perisylvian language networks of the human brain
journal, January 2004
- Catani, Marco; Jones, Derek K.; ffytche, Dominic H.
- Annals of Neurology, Vol. 57, Issue 1
Neuropsychological Characteristics of the Syndrome of Mesial Temporal Lobe Epilepsy
journal, April 1997
- Hermann, B. P.; Seidenberg, M.; Schoenfeld, J.
- Archives of Neurology, Vol. 54, Issue 4
Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy
journal, September 2008
- Takaya, Shigetoshi; Mikuni, Nobuhiro; Mitsueda, Takahiro
- Brain, Vol. 132, Issue 1
Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy
journal, December 1997
- Jokeit, H.
- Brain, Vol. 120, Issue 12
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
journal, July 2011
- Petanjek, Zdravko; Judaš, Miloš; Šimić, Goran
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 32
Effect of lateralized temporal lobe epilepsy on the default mode network
journal, November 2012
- Haneef, Zulfi; Lenartowicz, Agatha; Yeh, Hsiang J.
- Epilepsy & Behavior, Vol. 25, Issue 3
White matter abnormalities in children and adolescents with temporal lobe epilepsy
journal, November 2010
- Meng, Lu; Xiang, Jing; Kotecha, Rupesh
- Magnetic Resonance Imaging, Vol. 28, Issue 9
Neural correlates of recovery from aphasia after damage to left inferior frontal cortex
journal, December 2000
- Rosen, H. J.; Petersen, S. E.; Linenweber, M. R.
- Neurology, Vol. 55, Issue 12
Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy
journal, May 2008
- Yogarajah, M.; Powell, H. W. R.; Parker, G. J. M.
- NeuroImage, Vol. 40, Issue 4
Abnormalities of language networks in temporal lobe epilepsy
journal, May 2007
- Powell, H. W. Robert; Parker, Geoff J. M.; Alexander, Daniel C.
- NeuroImage, Vol. 36, Issue 1
Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery After Neocortical Infarction in Rats
journal, November 1995
- Stroemer, R. Paul; Kent, Thomas A.; Hulsebosch, Claire E.
- Stroke, Vol. 26, Issue 11
Structural correlates of impaired working memory in hippocampal sclerosis
journal, April 2013
- Winston, Gavin P.; Stretton, Jason; Sidhu, Meneka K.
- Epilepsia, Vol. 54, Issue 7
Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy
journal, May 1996
- Arnold, S.; Schlaug, G.; Niemann, H.
- Neurology, Vol. 46, Issue 5
Myelination of Cortical-hippocampal Relays During Late Adolescence
journal, January 1989
- Benes, F. M.
- Schizophrenia Bulletin, Vol. 15, Issue 4
Inosine induces axonal rewiring and improves behavioral outcome after stroke
journal, June 2002
- Chen, P.; Goldberg, D. E.; Kolb, B.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 13
Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
journal, April 2008
- Focke, Niels K.; Yogarajah, Mahinda; Bonelli, Silvia B.
- NeuroImage, Vol. 40, Issue 2
Brain regions underlying word finding difficulties in temporal lobe epilepsy
journal, April 2009
- Fonseca, Agnes Trebuchon-Da; Guedj, Eric; Alario, F-Xavier
- Brain, Vol. 132, Issue 10
Distinct right frontal lobe activation in language processing following left hemisphere injury
journal, November 2005
- Voets, N. L.; Adcock, J. E.; Flitney, D. E.
- Brain, Vol. 129, Issue 3
Changes in white matter microstructure during adolescence
journal, January 2008
- Giorgio, A.; Watkins, K. E.; Douaud, G.
- NeuroImage, Vol. 39, Issue 1
Cortical thickness analysis in temporal lobe epilepsy: Reproducibility and relation to outcome
journal, May 2010
- Bernhardt, B. C.; Bernasconi, N.; Concha, L.
- Neurology, Vol. 74, Issue 22
Side Matters: Diffusion Tensor Imaging Tractography in Left and Right Temporal Lobe Epilepsy
journal, June 2009
- Ahmadi, M. E.; Hagler, D. J.; McDonald, C. R.
- American Journal of Neuroradiology, Vol. 30, Issue 9
White Matter Development in Adolescence: A DTI Study
journal, January 2010
- Asato, M. R.; Terwilliger, R.; Woo, J.
- Cerebral Cortex, Vol. 20, Issue 9
fMRI language dominance and FDG-PET hypometabolism
journal, March 2011
- Gaillard, W. D.; Berl, M. M.; Duke, E. S.
- Neurology, Vol. 76, Issue 15
Cortical Surface-Based Analysis
journal, February 1999
- Dale, Anders M.; Fischl, Bruce; Sereno, Martin I.
- NeuroImage, Vol. 9, Issue 2
Network Alterations Supporting Word Retrieval in Patients with Medial Temporal Lobe Epilepsy
journal, September 2011
- Protzner, Andrea B.; McAndrews, Mary Pat
- Journal of Cognitive Neuroscience, Vol. 23, Issue 9
TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia
journal, December 2011
- Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo
- Brain and Language, Vol. 119, Issue 3
Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis
journal, June 2009
- Mueller, S. G.; Laxer, K. D.; Barakos, J.
- NeuroImage, Vol. 46, Issue 2
The evolution of the arcuate fasciculus revealed with comparative DTI
journal, March 2008
- Rilling, James K.; Glasser, Matthew F.; Preuss, Todd M.
- Nature Neuroscience, Vol. 11, Issue 4
Functional MRI of Language: New Approaches to Understanding the Cortical Organization of Semantic Processing
journal, March 2002
- Bookheimer, Susan
- Annual Review of Neuroscience, Vol. 25, Issue 1
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
journal, July 2006
- Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce
- NeuroImage, Vol. 31, Issue 3
Left-sided Interictal Epileptic Activity Induces Shift of Language Lateralization in Temporal Lobe Epilepsy: An fMRI Study
journal, May 2006
- Janszky, Jozsef; Mertens, Markus; Janszky, Imre
- Epilepsia, Vol. 47, Issue 5
Microdysgenesis in mesial temporal lobe epilepsy: A clinicopathological study
journal, September 2003
- Kasper, Burkhard S.; Stefan, Hermann; Paulus, Werner
- Annals of Neurology, Vol. 54, Issue 4
Recovery from nonfluent aphasia after melodic intonation therapy: A PET study
journal, December 1996
- Belin, P.; Zilbovicius, M.; Remy, Ph.
- Neurology, Vol. 47, Issue 6
Functional MRI measurement of language Lateralization in Wada-tested patients
journal, January 1995
- Desmond, J. E.; Sum, J. M.; Wagner, A. D.
- Brain, Vol. 118, Issue 6
Chronic epilepsy and cognition: A longitudinal study in temporal lobe epilepsy
journal, September 2003
- Helmstaedter, Christoph; Kurthen, Martin; Lux, Silke
- Annals of Neurology, Vol. 54, Issue 4
Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex
journal, September 2005
- Badre, David; Poldrack, Russell A.; Paré-Blagoev, E. Juliana
- Neuron, Vol. 47, Issue 6
Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy
journal, November 2006
- Takaya, S.; Hanakawa, T.; Hashikawa, K.
- Neurology, Vol. 67, Issue 9
Voxel-based morphometry of temporal lobe epilepsy: An introduction and review of the literature
journal, May 2008
- Keller, Simon Sean; Roberts, Neil
- Epilepsia, Vol. 49, Issue 5
Atypical language lateralisation associated with right fronto-temporal grey matter increases — a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients
journal, January 2012
- Labudda, Kirsten; Mertens, Markus; Janszky, Jozsef
- NeuroImage, Vol. 59, Issue 1
A lateralized brain network for visuospatial attention
journal, September 2011
- de Schotten, Michel Thiebaut; Dell'Acqua, Flavio; Forkel, Stephanie J.
- Nature Neuroscience, Vol. 14, Issue 10
Psychophysiological and Modulatory Interactions in Neuroimaging
journal, October 1997
- Friston, K. J.; Buechel, C.; Fink, G. R.
- NeuroImage, Vol. 6, Issue 3
Anterior temporal abnormality in temporal lobe epilepsy: A quantitative MRI and histopathologic study
journal, January 1999
- Mitchell, L. A.; Jackson, G. D.; Kalnins, R. M.
- Neurology, Vol. 52, Issue 2
Quality of life and memory performance in patients with temporal lobe epilepsy
journal, May 2000
- Giovagnoli, A. R.; Avanzini, G.
- Acta Neurologica Scandinavica, Vol. 101, Issue 5
Stimulating conversation: Enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation
journal, April 2010
- Hamilton, Roy H.; Sanders, Linda; Benson, Jennifer
- Brain and Language, Vol. 113, Issue 1
Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A reevaluation
journal, December 1997
- Thompson-Schill, S. L.; D'Esposito, M.; Aguirre, G. K.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 26
DTI Tractography of the Human Brain's Language Pathways
journal, February 2008
- Glasser, Matthew F.; Rilling, James K.
- Cerebral Cortex, Vol. 18, Issue 11
The nature and course of neuropsychological morbidity in chronic temporal lobe epilepsy
journal, May 2004
- Oyegbile, T. O.; Dow, C.; Jones, J.
- Neurology, Vol. 62, Issue 10
Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy
journal, October 2004
- Bernasconi, N.; Duchesne, S.; Janke, A.
- NeuroImage, Vol. 23, Issue 2
Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy
journal, August 2008
- Diehl, Beate; Busch, Robyn M.; Duncan, John S.
- Epilepsia, Vol. 49, Issue 8
Recovering Meaning
journal, August 2001
- Wagner, Anthony D.; Paré-Blagoev, E. Juliana; Clark, Jill
- Neuron, Vol. 31, Issue 2
The interictal language profile in adult epilepsy
journal, August 2014
- Bartha-Doering, Lisa; Trinka, Eugen
- Epilepsia, Vol. 55, Issue 10
Functional anatomy of a common semantic system for words and pictures
journal, September 1996
- Vandenberghe, R.; Price, C.; Wise, R.
- Nature, Vol. 383, Issue 6597
Lateralization of ventral and dorsal auditory-language pathways in the human brain
journal, February 2005
- Parker, Geoffrey J. M.; Luzzi, Simona; Alexander, Daniel C.
- NeuroImage, Vol. 24, Issue 3
Measuring the thickness of the human cerebral cortex from magnetic resonance images
journal, September 2000
- Fischl, B.; Dale, A. M.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 20
Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
journal, July 2008
- Govindan, Rajkumar Munian; Makki, Malek I.; Sundaram, Senthil K.
- Epilepsy Research, Vol. 80, Issue 1
Role of Frontotemporal Fiber Tract Integrity in Task-Switching Performance of Healthy Controls and Patients with Temporal Lobe Epilepsy
journal, October 2011
- Kucukboyaci, N. Erkut; Girard, H. M.; Hagler, D. J.
- Journal of the International Neuropsychological Society, Vol. 18, Issue 1
Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy
journal, February 2003
- Adcock, J. E.; Wise, R. G.; Oxbury, J. M.
- NeuroImage, Vol. 18, Issue 2
Regional neocortical thinning in mesial temporal lobe epilepsy
journal, May 2008
- McDonald, Carrie R.; Hagler, Donald J.; Ahmadi, Mazyar E.
- Epilepsia, Vol. 49, Issue 5
Human Brain Language Areas Identified by Functional Magnetic Resonance Imaging
journal, January 1997
- Binder, Jeffrey R.; Frost, Julie A.; Hammeke, Thomas A.
- The Journal of Neuroscience, Vol. 17, Issue 1
Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity
journal, September 1995
- Demb, Jb; Desmond, Je; Wagner, Ad
- The Journal of Neuroscience, Vol. 15, Issue 9
Works referencing / citing this record:
Network Modeling of Epilepsy Using Structural and Functional MRI
book, January 2019
- Caciagli, Lorenzo; Bernhardt, Boris C.; Bernasconi, Andrea
- Imaging Biomarkers in Epilepsy