Cerebral glucose metabolism in Wernicke's, Broca's, and conduction aphasia

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1989.00520370029014· OSTI ID:6396788

Metter, E J; Kempler, D; Jackson, C; Hanson, W R; Mazziotta, J C; Phelps, M E

Cerebral glucose metabolism was evaluated in patients with either Wernicke's (N = 7), Broca's (N = 11), or conduction (N = 10) aphasia using /sup 18/F-2-fluoro-2-deoxy-D-glucose with positron emission tomography. The three aphasic syndromes differed in the degree of left-to-right frontal metabolic asymmetry, with Broca's aphasia showing severe asymmetry and Wernicke's aphasia mild-to-moderate metabolic asymmetry, while patients with conduction aphasia were metabolically symmetric. On the other hand, the three syndromes showed the same degree of metabolic decline in the left temporal region. The parietal region appeared to separate conduction aphasia from both Broca's and Wernicke's aphasias. Common aphasic features in the three syndromes appear to be due to common changes in the temporal region, while unique features were associated with frontal and parietal metabolic differences.

• Research Organization: Veterans Administration Medical Center, Sepulveda, CA (USA)
• OSTI ID: 6396788
• Journal Information: Arch. Neurol.; (United States), Vol. 46:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
FLUORINE 18
NERVOUS SYSTEM DISEASES
PATIENTS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics