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FDG positron emission computed tomography in a study of aphasia

Journal Article · · Ann. Neurol.; (United States)
; ; ; ;

Positron emission computed tomography (PECT) using 18F-2-fluoro-2-deoxy-D-glucose (FDG) was used to investigate the correlations between clinical status, anatomy (as described by CT), and metabolism in five patients with stable aphasia resulting from ischemic cerebral infarction. Local cerebral metabolic activity was diminished in an area larger than the area of infarction demonstrated by CT. In one patient, FDG PECT revealed a metabolic lesion that probably caused the aphasic syndrome and was not apparent by CT. The data suggest that reliance on CT in delineating the extent of the brain lesion in aphasia or other neuropsychological defects can be misleading; FDG PECT may provide important additional information. Two patients with similar metabolic lesions had very different clinical syndromes, showing that even when currently available methods are combined, major gaps remain in clinicoanatomical correlations in aphasia.

OSTI ID:
5476645
Journal Information:
Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 10:2; ISSN ANNED
Country of Publication:
United States
Language:
English

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550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANATOMY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
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FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISCHEMIA
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LIGHT NUCLEI
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
USES
VASCULAR DISEASES