Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus
Abstract
Several studies have explored the origin and development mechanism of oral lichen planus (OLP) with limited attention to the role of bacteria in the progression of this common oral disease. Here we utilized MiSeq sequencing of 16S rRNA gene amplicons to identify complex oral microbiota associated with OLP from saliva samples of two subtypes (reticular and erosive) of OLP patients and healthy controls. Our analyses indicated that the overall structure of the salivary microbiome was not significantly affected by disease status. However, we did observe evident variations in abundance for several taxonomic groups in OLP. Porphyromonas and Solobacterium showed significantly higher relative abundances, whereas Haemophilus, Corynebacterium, Cellulosimicrobium and Campylobacter showed lower abundances in OLP patients, as compared with healthy controls. In addition, we explored specific microbial co-occurrence patterns in OLP, and revealed significantly fewer linkers of Streptococcus comprising species in erosive OLP. Furthermore, the disease severity and immune dysregulation were also genus-associated, including with Porphyromonas that correlated to disease scores and salivary levels of interleukin (IL)-17 and IL-23. Overall, this study provides a general description of oral microbiome in OLP, and it will be useful for further investigation of their potential roles in the initiation and immune modulation of OLP.
- Authors:
-
- Sichuan Univ., Chengdu (China). West China Hospital of Stomatology, State Key Lab. of Oral Diseases
- Zhejiang Univ. (China). Dept. of Marine Sciences; Univ. of Oklahoma, Norman, OK (United States). Inst. for Environmental Genomics, Dept. of Microbiology
- Univ. of Oklahoma, Norman, OK (United States). Inst. for Environmental Genomics, Dept. of Microbiology and Plant Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Natural Science Foundation of China (NSFC)
- OSTI Identifier:
- 1580075
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Wang, Kun, Lu, Wenxin, Tu, Qichao, Ge, Yichen, He, Jinzhi, Zhou, Yu, Gou, Yaping, Van Nostrand, Joy D., Qin, Yujia, Li, Jiyao, Zhou, Jizhong, Li, Yan, Xiao, Liying, and Zhou, Xuedong. Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus. United States: N. p., 2016.
Web. doi:10.1038/srep22943.
Wang, Kun, Lu, Wenxin, Tu, Qichao, Ge, Yichen, He, Jinzhi, Zhou, Yu, Gou, Yaping, Van Nostrand, Joy D., Qin, Yujia, Li, Jiyao, Zhou, Jizhong, Li, Yan, Xiao, Liying, & Zhou, Xuedong. Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus. United States. https://doi.org/10.1038/srep22943
Wang, Kun, Lu, Wenxin, Tu, Qichao, Ge, Yichen, He, Jinzhi, Zhou, Yu, Gou, Yaping, Van Nostrand, Joy D., Qin, Yujia, Li, Jiyao, Zhou, Jizhong, Li, Yan, Xiao, Liying, and Zhou, Xuedong. Thu .
"Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus". United States. https://doi.org/10.1038/srep22943. https://www.osti.gov/servlets/purl/1580075.
@article{osti_1580075,
title = {Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus},
author = {Wang, Kun and Lu, Wenxin and Tu, Qichao and Ge, Yichen and He, Jinzhi and Zhou, Yu and Gou, Yaping and Van Nostrand, Joy D. and Qin, Yujia and Li, Jiyao and Zhou, Jizhong and Li, Yan and Xiao, Liying and Zhou, Xuedong},
abstractNote = {Several studies have explored the origin and development mechanism of oral lichen planus (OLP) with limited attention to the role of bacteria in the progression of this common oral disease. Here we utilized MiSeq sequencing of 16S rRNA gene amplicons to identify complex oral microbiota associated with OLP from saliva samples of two subtypes (reticular and erosive) of OLP patients and healthy controls. Our analyses indicated that the overall structure of the salivary microbiome was not significantly affected by disease status. However, we did observe evident variations in abundance for several taxonomic groups in OLP. Porphyromonas and Solobacterium showed significantly higher relative abundances, whereas Haemophilus, Corynebacterium, Cellulosimicrobium and Campylobacter showed lower abundances in OLP patients, as compared with healthy controls. In addition, we explored specific microbial co-occurrence patterns in OLP, and revealed significantly fewer linkers of Streptococcus comprising species in erosive OLP. Furthermore, the disease severity and immune dysregulation were also genus-associated, including with Porphyromonas that correlated to disease scores and salivary levels of interleukin (IL)-17 and IL-23. Overall, this study provides a general description of oral microbiome in OLP, and it will be useful for further investigation of their potential roles in the initiation and immune modulation of OLP.},
doi = {10.1038/srep22943},
journal = {Scientific Reports},
number = 1,
volume = 6,
place = {United States},
year = {Thu Mar 10 00:00:00 EST 2016},
month = {Thu Mar 10 00:00:00 EST 2016}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 102 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Defining the healthy "core microbiome" of oral microbial communities
journal, January 2009
- Zaura, Egija; Keijser, Bart JF; Huse, Susan M.
- BMC Microbiology, Vol. 9, Issue 1
Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
journal, September 2013
- Said, H. S.; Suda, W.; Nakagome, S.
- DNA Research, Vol. 21, Issue 1
Molecular ecological network analyses
journal, January 2012
- Deng, Ye; Jiang, Yi-Huei; Yang, Yunfeng
- BMC Bioinformatics, Vol. 13, Issue 1
Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus
journal, June 2012
- Xie, Sanxiang; Ding, Lei; Xiong, Zhigang
- Journal of Huazhong University of Science and Technology [Medical Sciences], Vol. 32, Issue 3
Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus: Oral microbiota and interleukin17 in OLP
journal, March 2015
- Wang, Kun; Miao, Tianyu; Lu, Wenxin
- Microbiology and Immunology, Vol. 59, Issue 3
Pyrosequencing analysis of the Oral Microflora of healthy adults
journal, November 2008
- Keijser, B. J. F.; Zaura, E.; Huse, S. M.
- Journal of Dental Research, Vol. 87, Issue 11
Cytoscape 2.8: new features for data integration and network visualization
journal, December 2010
- Smoot, M. E.; Ono, K.; Ruscheinski, J.
- Bioinformatics, Vol. 27, Issue 3
Oral lichen planus: a review
journal, August 2000
- Mollaoglu, N.
- British Journal of Oral and Maxillofacial Surgery, Vol. 38, Issue 4
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
journal, January 2013
- Abusleme, Loreto; Dupuy, Amanda K.; Dutzan, Nicolás
- The ISME Journal, Vol. 7, Issue 5
Prevalence of New Candidate Pathogens Prevotella baroniae, Prevotella multisaccharivorax and As-yet-uncultivated Bacteroidetes clone X083 in Primary Endodontic Infections
journal, October 2009
- Rôças, Isabela N.; Siqueira, José F.
- Journal of Endodontics, Vol. 35, Issue 10
attract: A Method for Identifying Core Pathways That Define Cellular Phenotypes
journal, October 2011
- Mar, Jessica C.; Matigian, Nicholas A.; Quackenbush, John
- PLoS ONE, Vol. 6, Issue 10
Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum
journal, January 2013
- Wang, Hui; Luo, Zhenhua; Lei, Lei
- Inflammation, Vol. 36, Issue 3
Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross-Sectional Comparative Study
journal, December 2008
- Bornstein, Michael M.; Hakimi, Basir; Persson, G. Rutger
- Journal of Periodontology, Vol. 79, Issue 12
Computing topological parameters of biological networks
journal, November 2007
- Assenov, Yassen; Ramírez, Fidel; Schelhorn, Sven-Eric
- Bioinformatics, Vol. 24, Issue 2
Investigating the biological and clinical significance of human dysbioses
journal, September 2011
- Frank, Daniel N.; Zhu, Wei; Sartor, R. Balfour
- Trends in Microbiology, Vol. 19, Issue 9
Methods for Collecting Saliva
journal, September 1993
- Navazesh, Mahvash
- Annals of the New York Academy of Sciences, Vol. 694, Issue 1 Saliva as a D
FOXP3+ T regulatory cells in lesions of oral lichen planus correlated with disease activity: FOXP3+ T regulatory cells in OLP patients
journal, January 2010
- Tao, X-a; Xia, J.; Chen, X-b
- Oral Diseases, Vol. 16, Issue 1
Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis
journal, June 2013
- Seckin Ertugrul, Abdullah; Arslan, Ugur; Dursun, Recep
- International Journal of Oral Science, Vol. 5, Issue 2
Saliva microbiomes distinguish caries-active from healthy human populations
journal, June 2011
- Yang, Fang; Zeng, Xiaowei; Ning, Kang
- The ISME Journal, Vol. 6, Issue 1
Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities
journal, October 2009
- Schloss, P. D.; Westcott, S. L.; Ryabin, T.
- Applied and Environmental Microbiology, Vol. 75, Issue 23, p. 7537-7541
The Effect of Probiotics and Gut Microbiota on Th17 Cells
journal, October 2013
- Tanabe, Soichi
- International Reviews of Immunology, Vol. 32, Issue 5-6
White lichenoid lesions of the buccal mucosa in patients with HIV infection
journal, October 1993
- Ficarra, Giuseppe; Flaitz, Catherine M.; Gaglioti, Domenico
- Oral Surgery, Oral Medicine, Oral Pathology, Vol. 76, Issue 4
Upper gastrointestinal findings and detection of Helicobacter pylori in patients with oral lichen planus
journal, June 2010
- Attia, E. A. S.; Abdel Fattah, N. S. A.; Abdella, H. M.
- Clinical and Experimental Dermatology, Vol. 35, Issue 4
Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa
journal, May 2002
- Sand, Lars Peter; Jalouli, Jamshid; Larsson, Per-Anders
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 93, Issue 5
Metagenomic analysis for detecting pathogens in culture-negative infective endocarditis
journal, December 2015
- Fukui, Yuto; Aoki, Kotaro; Okuma, Shinnosuke
- Journal of Infection and Chemotherapy, Vol. 21, Issue 12
Mucosal Microbiome in Patients with Recurrent Aphthous Stomatitis
journal, December 2014
- Hijazi, K.; Lowe, T.; Meharg, C.
- Journal of Dental Research, Vol. 94, Issue 3_suppl
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
journal, June 2007
- Wang, Q.; Garrity, G. M.; Tiedje, J. M.
- Applied and Environmental Microbiology, Vol. 73, Issue 16
Helicobacter pylori in oral ulcerations.
journal, January 2000
- Shimoyama, Tetsuo; Horie, Norio; Kato, Takao
- Journal of Oral Science, Vol. 42, Issue 4
Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients
journal, March 2014
- Li, Yan; He, Jinzhi; He, Zhili
- The ISME Journal, Vol. 8, Issue 9
Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis
journal, June 2014
- Maekawa, Tomoki; Krauss, Jennifer L.; Abe, Toshiharu
- Cell Host & Microbe, Vol. 15, Issue 6
Detection and identification of non-Candida albicans species in human oral lichen planus: Non-Candida albicans in oral lichen planus
journal, December 2010
- Masaki, Mika; Sato, Takuichi; Sugawara, Yumiko
- Microbiology and Immunology, Vol. 55, Issue 1
Modularity and community structure in networks
journal, May 2006
- Newman, M. E. J.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 23
Human cytomegalovirus as a potential etiologic agent in recurrent aphthous ulcers and Behcet's disease
journal, May 1996
- Sun, A.; Chang, J. -G.; Kao, C. -L.
- Journal of Oral Pathology and Medicine, Vol. 25, Issue 5
Porphyromonas gingivalis infection enhances Th17 responses for development of atherosclerosis
journal, November 2014
- Cai, Yu; Kobayashi, Ryoki; Hashizume-Takizawa, Tomomi
- Archives of Oral Biology, Vol. 59, Issue 11
Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis
journal, July 2005
- Lodi, Giovanni; Scully, Crispian; Carrozzo, Marco
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 100, Issue 1
Microbial-associated oral lichenoid reactions
journal, July 2007
- Bäckman, K.; Jontell, M.
- Oral Diseases, Vol. 13, Issue 4
No evidence for Helicobacter pylori in oral lichen planus
journal, April 2014
- Hulimavu, Shwetha R.; Mohanty, Leeky; V. Tondikulam, Narayan
- Journal of Oral Pathology & Medicine, Vol. 43, Issue 8
Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications
journal, October 2003
- van der Meij, E. H.; van der Waal, I.
- Journal of Oral Pathology and Medicine, Vol. 32, Issue 9
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation
journal, January 2007
- Ismail, Sumairi B.; Kumar, Satish K. S.; Zain, Rosnah B.
- Journal of Oral Science, Vol. 49, Issue 2
Cytokine profiles in serum of patients with oral lichen planus
journal, December 2012
- Pekiner, Filiz Namdar; Demirel, Gülderen Yanıkkaya; Borahan, Mehmet Oğuz
- Cytokine, Vol. 60, Issue 3
Microbial Co-occurrence Relationships in the Human Microbiome
journal, July 2012
- Faust, Karoline; Sathirapongsasuti, J. Fah; Izard, Jacques
- PLoS Computational Biology, Vol. 8, Issue 7
Hepatitis C virus infection in patients with oral lichen planus
journal, January 2011
- Konidena, A.; Pavani, Bv
- Nigerian Journal of Clinical Practice, Vol. 14, Issue 2
Innate IL-17 and IL-22 responses to enteric bacterial pathogens
journal, March 2012
- Rubino, Stephen J.; Geddes, Kaoru; Girardin, Stephen E.
- Trends in Immunology, Vol. 33, Issue 3
Defining dysbiosis and its influence on host immunity and disease: How changes in microbiota structure influence health
journal, June 2014
- Petersen, Charisse; Round, June L.
- Cellular Microbiology, Vol. 16, Issue 7
Subgingival microbiome in patients with healthy and ailing dental implants
journal, June 2015
- Zheng, Hui; Xu, Lixin; Wang, Zicheng
- Scientific Reports, Vol. 5, Issue 1
Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum
journal, January 2013
- Wang, Hui; Luo, Zhenhua; Lei, Lei
- Inflammation, Vol. 36, Issue 3
Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus
journal, June 2012
- Xie, Sanxiang; Ding, Lei; Xiong, Zhigang
- Journal of Huazhong University of Science and Technology [Medical Sciences], Vol. 32, Issue 3
Effect of dental plaque control on gingival lichen planus
journal, May 1990
- Holmstrup, Palle; Schiøtz, Annette Westborg; Westergaard, Jytte
- Oral Surgery, Oral Medicine, Oral Pathology, Vol. 69, Issue 5
Porphyromonas gingivalis infection enhances Th17 responses for development of atherosclerosis
journal, November 2014
- Cai, Yu; Kobayashi, Ryoki; Hashizume-Takizawa, Tomomi
- Archives of Oral Biology, Vol. 59, Issue 11
Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis
journal, June 2014
- Maekawa, Tomoki; Krauss, Jennifer L.; Abe, Toshiharu
- Cell Host & Microbe, Vol. 15, Issue 6
Innate IL-17 and IL-22 responses to enteric bacterial pathogens
journal, March 2012
- Rubino, Stephen J.; Geddes, Kaoru; Girardin, Stephen E.
- Trends in Immunology, Vol. 33, Issue 3
Metagenomic analysis for detecting pathogens in culture-negative infective endocarditis
journal, December 2015
- Fukui, Yuto; Aoki, Kotaro; Okuma, Shinnosuke
- Journal of Infection and Chemotherapy, Vol. 21, Issue 12
Prevalence of New Candidate Pathogens Prevotella baroniae, Prevotella multisaccharivorax and As-yet-uncultivated Bacteroidetes clone X083 in Primary Endodontic Infections
journal, October 2009
- Rôças, Isabela N.; Siqueira, José F.
- Journal of Endodontics, Vol. 35, Issue 10
Investigating the biological and clinical significance of human dysbioses
journal, September 2011
- Frank, Daniel N.; Zhu, Wei; Sartor, R. Balfour
- Trends in Microbiology, Vol. 19, Issue 9
Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis
journal, July 2005
- Lodi, Giovanni; Scully, Crispian; Carrozzo, Marco
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 100, Issue 1
Candida in patients with oral lichen planus
journal, June 1984
- Lundström, Inger M. C.; Anneroth, Göran B.; Holmberg, Kenneth
- International Journal of Oral Surgery, Vol. 13, Issue 3
The evaluation of cutaneous, genital, scalp, nail, esophageal, and ocular involvement in patients with oral lichen planus
journal, October 1999
- Eisen, Drore
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 88, Issue 4
Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis
journal, June 2013
- Seckin Ertugrul, Abdullah; Arslan, Ugur; Dursun, Recep
- International Journal of Oral Science, Vol. 5, Issue 2
Saliva microbiomes distinguish caries-active from healthy human populations
journal, June 2011
- Yang, Fang; Zeng, Xiaowei; Ning, Kang
- The ISME Journal, Vol. 6, Issue 1
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
journal, January 2013
- Abusleme, Loreto; Dupuy, Amanda K.; Dutzan, Nicolás
- The ISME Journal, Vol. 7, Issue 5
Oral lichen planus: a review
journal, August 2000
- Mollaoglu, N.
- British Journal of Oral and Maxillofacial Surgery, Vol. 38, Issue 4
Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa
journal, May 2002
- Sand, Lars Peter; Jalouli, Jamshid; Larsson, Per-Anders
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 93, Issue 5
Computing topological parameters of biological networks
journal, November 2007
- Assenov, Yassen; Ramírez, Fidel; Schelhorn, Sven-Eric
- Bioinformatics, Vol. 24, Issue 2
Cytoscape 2.8: new features for data integration and network visualization
journal, December 2010
- Smoot, M. E.; Ono, K.; Ruscheinski, J.
- Bioinformatics, Vol. 27, Issue 3
Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
journal, September 2013
- Said, H. S.; Suda, W.; Nakagome, S.
- DNA Research, Vol. 21, Issue 1
Defining dysbiosis and its influence on host immunity and disease: How changes in microbiota structure influence health
journal, June 2014
- Petersen, Charisse; Round, June L.
- Cellular Microbiology, Vol. 16, Issue 7
Human cytomegalovirus as a potential etiologic agent in recurrent aphthous ulcers and Behcet's disease
journal, May 1996
- Sun, A.; Chang, J. -G.; Kao, C. -L.
- Journal of Oral Pathology and Medicine, Vol. 25, Issue 5
Methods for Collecting Saliva
journal, September 1993
- Navazesh, Mahvash
- Annals of the New York Academy of Sciences, Vol. 694, Issue 1 Saliva as a D
No evidence for Helicobacter pylori in oral lichen planus
journal, April 2014
- Hulimavu, Shwetha R.; Mohanty, Leeky; V. Tondikulam, Narayan
- Journal of Oral Pathology & Medicine, Vol. 43, Issue 8
Mucosal Microbiome in Patients with Recurrent Aphthous Stomatitis
journal, December 2014
- Hijazi, K.; Lowe, T.; Meharg, C.
- Journal of Dental Research, Vol. 94, Issue 3_suppl
Pyrosequencing analysis of the Oral Microflora of healthy adults
journal, November 2008
- Keijser, B. J. F.; Zaura, E.; Huse, S. M.
- Journal of Dental Research, Vol. 87, Issue 11
Molecular ecological network analyses
journal, January 2012
- Deng, Ye; Jiang, Yi-Huei; Yang, Yunfeng
- BMC Bioinformatics, Vol. 13, Issue 1
Defining the healthy "core microbiome" of oral microbial communities
journal, January 2009
- Zaura, Egija; Keijser, Bart JF; Huse, Susan M.
- BMC Microbiology, Vol. 9, Issue 1
Microbial Co-occurrence Relationships in the Human Microbiome
journal, July 2012
- Faust, Karoline; Sathirapongsasuti, J. Fah; Izard, Jacques
- PLoS Computational Biology, Vol. 8, Issue 7
Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross-Sectional Comparative Study
journal, December 2008
- Bornstein, Michael M.; Hakimi, Basir; Persson, G. Rutger
- Journal of Periodontology, Vol. 79, Issue 12
Helicobacter pylori in oral ulcerations.
journal, January 2000
- Shimoyama, Tetsuo; Horie, Norio; Kato, Takao
- Journal of Oral Science, Vol. 42, Issue 4
Works referencing / citing this record:
Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples
journal, November 2019
- Bajerski, F.; Bürger, A.; Glasmacher, B.
- Applied Microbiology and Biotechnology, Vol. 104, Issue 1
Oral microbiomes: more and more importance in oral cavity and whole body
journal, May 2018
- Gao, Lu; Xu, Tiansong; Huang, Gang
- Protein & Cell, Vol. 9, Issue 5
The Oral Microbiome Bank of China
journal, May 2018
- Xian, Peng; Xuedong, Zhou; Xin, Xu
- International Journal of Oral Science, Vol. 10, Issue 2
Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus
journal, June 2019
- Li, Yan; Wang, Kun; Zhang, Bo
- International Journal of Oral Science, Vol. 11, Issue 2
‘NetShift’: a methodology for understanding ‘driver microbes’ from healthy and disease microbiome datasets
journal, October 2018
- Kuntal, Bhusan K.; Chandrakar, Pranjal; Sadhu, Sudipta
- The ISME Journal, Vol. 13, Issue 2
Synergism between Corynebacterium and Streptococcus sanguinis reveals new interactions between oral commensals
journal, February 2020
- Treerat, Puthayalai; Redanz, Ulrike; Redanz, Sylvio
- The ISME Journal, Vol. 14, Issue 5
The core microbiome of sessile ciliate Stentor coeruleus is not shaped by the environment
journal, August 2019
- Lanzoni, Olivia; Plotnikov, Andrey; Khlopko, Yuri
- Scientific Reports, Vol. 9, Issue 1
No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism
journal, February 2020
- Vehviläinen, Mari; Salem, Abdelhakim; Asghar, Muhammad Yasir
- Acta Odontologica Scandinavica, Vol. 78, Issue 5
Detection of multi-dimensional co-exclusion patterns in microbial communities
journal, June 2018
- Albayrak, Levent; Khanipov, Kamil; Golovko, George
- Bioinformatics, Vol. 34, Issue 21
ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples
journal, May 2019
- Gonzalez, Emmanuel; Pitre, Frederic E.; Brereton, Nicholas J. B.
- Environmental Microbiology, Vol. 21, Issue 7
A survey of the oral cavity microbiome of New Zealand fur seal pups ( Arctocephalus forsteri )
journal, June 2019
- Emami‐Khoyi, Arsalan; Benmazouz, Isma; Ross, James G.
- Marine Mammal Science, Vol. 36, Issue 1
The oral microbiome in oral lichen planus during a 1‐year randomized clinical trial
journal, February 2018
- Kragelund, Camilla; Keller, Mette Kirstine
- Oral Diseases, Vol. 25, Issue 1
World Workshop on Oral Medicine VII: Targeting the oral microbiome Part 2: Current knowledge on malignant and potentially malignant oral disorders
journal, May 2019
- Robledo‐Sierra, Jairo; Ben‐Amy, Dalit Porat; Varoni, Elena
- Oral Diseases, Vol. 25, Issue S1
The dynamics of the oral microbiome and oral health among patients receiving clear aligner orthodontic treatment
journal, November 2019
- Zhao, Rui; Huang, Renhuan; Long, Hu
- Oral Diseases, Vol. 26, Issue 2
Potential association between Fusobacterium nucleatum enrichment on oral mucosal surface and oral lichen planus
journal, November 2019
- Du, Guan‐huan; Wang, Yu‐feng; Chen, Jun‐jun
- Oral Diseases, Vol. 26, Issue 1
The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?
journal, October 2017
- Baek, K.; Choi, Y.
- Molecular Oral Microbiology, Vol. 33, Issue 1
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
journal, January 2019
- Chattopadhyay, Indranil; Verma, Mukesh; Panda, Madhusmita
- Technology in Cancer Research & Treatment, Vol. 18
Dysbiosis of saliva microbiome in patients with oral lichen planus
journal, April 2020
- Yu, Fei Yan; Wang, Qian Qian; Li, Miao
- BMC Microbiology, Vol. 20, Issue 1
Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach
journal, January 2018
- Wang, Kun; Wang, Yufei; Wang, Xiuqing
- Journal of Translational Medicine, Vol. 16, Issue 1
iTRAQ-based quantitative analysis of age-specific variations in salivary proteome of caries-susceptible individuals
journal, October 2018
- Wang, Kun; Wang, Xiuqing; Zheng, Sainan
- Journal of Translational Medicine, Vol. 16, Issue 1
Unraveling the human salivary microbiome diversity in Indian populations
journal, September 2017
- Sarkar, Anujit; Stoneking, Mark; Nandineni, Madhusudan R.
- PLOS ONE, Vol. 12, Issue 9
Ecological Shifts of Supragingival Microbiota in Association with Pregnancy
journal, February 2018
- Lin, Wenzhen; Jiang, Wenxin; Hu, Xuchen
- Frontiers in Cellular and Infection Microbiology, Vol. 8
Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus
journal, April 2019
- Salem, Abdelhakim; Almahmoudi, Rabeia; Hagström, Jaana
- International Journal of Molecular Sciences, Vol. 20, Issue 7
The Oral Microbiome Bank of China
book, January 2021
- Peng, Xian; Zhou, Xuedong; Xu, Xin
- Atlas of Oral Microbiology: From Healthy Microflora to Disease
Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples
other, January 2020
- Bajerski, F.; Bürger, A.; Glasmacher, B.
- Heidelberg : Springer Verlag
Species Level Description of the Human Ileal Bacterial Microbiota
journal, March 2018
- Villmones, Heidi Cecilie; Haug, Erik Skaaheim; Ulvestad, Elling
- Scientific Reports, Vol. 8, Issue 1
Characterization of intratissue bacterial communities and isolation of Escherichia coli from oral lichen planus lesions
journal, February 2020
- Baek, Keumjin; Lee, Jaewon; Lee, Ahreum
- Scientific Reports, Vol. 10, Issue 1
ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples
journal, May 2019
- Gonzalez, Emmanuel; Pitre, Frederic E.; Brereton, Nicholas J. B.
- Environmental Microbiology, Vol. 21, Issue 7
Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach
journal, January 2018
- Wang, Kun; Wang, Yufei; Wang, Xiuqing
- Journal of Translational Medicine, Vol. 16, Issue 1
Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study
journal, January 2019
- Yokoi, Aya; Ekuni, Daisuke; Hata, Hironobu
- Journal of Applied Oral Science, Vol. 27
Ecological Shifts of Supragingival Microbiota in Association with Pregnancy
journal, February 2018
- Lin, Wenzhen; Jiang, Wenxin; Hu, Xuchen
- Frontiers in Cellular and Infection Microbiology, Vol. 8
Commensal and Pathogenic Members of the Dental Calculus Microbiome of Badia Pozzeveri Individuals from the 11th to 19th Centuries
journal, April 2019
- Santiago-Rodriguez,
- Genes, Vol. 10, Issue 4