Characterization of the salivary microbiome in patients with pancreatic cancer
Abstract
Clinical manifestations of pancreatic cancer often do not occur until the cancer has undergone metastasis, resulting in a very low survival rate. In this study, we investigated whether salivary bacterial profiles might provide useful biomarkers for early detection of pancreatic cancer. Using high-throughput sequencing of bacterial small subunit ribosomal RNA (16S rRNA) gene, we characterized the salivary microbiota of patients with pancreatic cancer and compared them to healthy patients and patients with other diseases, including pancreatic disease, non-pancreatic digestive disease/cancer and non-digestive disease/cancer. A total of 146 patients were enrolled at the UCSD Moores Cancer Center where saliva and demographic data were collected from each patient. Of these, we analyzed the salivary microbiome of 108 patients: 8 had been diagnosed with pancreatic cancer, 78 with other diseases and 22 were classified as non-diseased (healthy) controls. Bacterial 16S rRNA sequences were amplified directly from salivary DNA extractions and subjected to high-throughput sequencing (HTS). Several bacterial genera differed in abundance in patients with pancreatic cancer. We found a significantly higher ratio ofLeptotrichiatoPorphyromonasin the saliva of patients with pancreatic cancer than in the saliva of healthy patients or those with other disease (Kruskal–Wallis Test;P< 0.001).Leptotrichiaabundances were confirmed using real-time qPCR withLeptotrichiaspecific primers. Similarmore »
- Authors:
-
- Department of Biology, San Diego State University, San Diego, CA, United States
- Department of Medical Sciences, Harvard University, Boston, MA, United States
- Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, United States; Institute for Genomics and Systems Biology, Argonne National Laboratory, Lemont, IL, United States
- Department of Surgery, University of California, San Diego, La Jolla, CA, United States
- Department of Biology, San Diego State University, San Diego, CA, United States; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, United States
- Publication Date:
- Research Org.:
- Argonne National Lab (ANL), Lemont, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institutes of Health (NIH) Public Health Service; Environmental Protection Agency (EPA) STAR Graduate Fellowship
- OSTI Identifier:
- 1628923
- Grant/Contract Number:
- AC02-06CH11357; U54CA132384; U54CA132379; R25GM058906; 5T-32EB-009412
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PeerJ
- Additional Journal Information:
- Journal Volume: 3; Journal ID: ISSN 2167-8359
- Publisher:
- PeerJ Inc.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- Science & Technology - Other Topics
Citation Formats
Torres, Pedro J., Fletcher, Erin M., Gibbons, Sean M., Bouvet, Michael, Doran, Kelly S., and Kelley, Scott T. Characterization of the salivary microbiome in patients with pancreatic cancer. United States: N. p., 2015.
Web. doi:10.7717/peerj.1373.
Torres, Pedro J., Fletcher, Erin M., Gibbons, Sean M., Bouvet, Michael, Doran, Kelly S., & Kelley, Scott T. Characterization of the salivary microbiome in patients with pancreatic cancer. United States. https://doi.org/10.7717/peerj.1373
Torres, Pedro J., Fletcher, Erin M., Gibbons, Sean M., Bouvet, Michael, Doran, Kelly S., and Kelley, Scott T. Thu .
"Characterization of the salivary microbiome in patients with pancreatic cancer". United States. https://doi.org/10.7717/peerj.1373. https://www.osti.gov/servlets/purl/1628923.
@article{osti_1628923,
title = {Characterization of the salivary microbiome in patients with pancreatic cancer},
author = {Torres, Pedro J. and Fletcher, Erin M. and Gibbons, Sean M. and Bouvet, Michael and Doran, Kelly S. and Kelley, Scott T.},
abstractNote = {Clinical manifestations of pancreatic cancer often do not occur until the cancer has undergone metastasis, resulting in a very low survival rate. In this study, we investigated whether salivary bacterial profiles might provide useful biomarkers for early detection of pancreatic cancer. Using high-throughput sequencing of bacterial small subunit ribosomal RNA (16S rRNA) gene, we characterized the salivary microbiota of patients with pancreatic cancer and compared them to healthy patients and patients with other diseases, including pancreatic disease, non-pancreatic digestive disease/cancer and non-digestive disease/cancer. A total of 146 patients were enrolled at the UCSD Moores Cancer Center where saliva and demographic data were collected from each patient. Of these, we analyzed the salivary microbiome of 108 patients: 8 had been diagnosed with pancreatic cancer, 78 with other diseases and 22 were classified as non-diseased (healthy) controls. Bacterial 16S rRNA sequences were amplified directly from salivary DNA extractions and subjected to high-throughput sequencing (HTS). Several bacterial genera differed in abundance in patients with pancreatic cancer. We found a significantly higher ratio ofLeptotrichiatoPorphyromonasin the saliva of patients with pancreatic cancer than in the saliva of healthy patients or those with other disease (Kruskal–Wallis Test;P< 0.001).Leptotrichiaabundances were confirmed using real-time qPCR withLeptotrichiaspecific primers. Similar to previous studies, we found lower relative abundances ofNeisseriaandAggregatibacterin the saliva of pancreatic cancer patients, though these results were not significant at theP< 0.05 level (K–W Test;P= 0.07 andP= 0.09 respectively). However, the relative abundances of other previously identified bacterial biomarkers, e.g.,Streptococcus mitisandGranulicatella adiacens, were not significantly different in the saliva of pancreatic cancer patients. Overall, this study supports the hypothesis that bacteria abundance profiles in saliva are useful biomarkers for pancreatic cancer though much larger patient studies are needed to verify their predictive utility.},
doi = {10.7717/peerj.1373},
journal = {PeerJ},
number = ,
volume = 3,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2015},
month = {Thu Jan 01 00:00:00 EST 2015}
}
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Works referenced in this record:
Defining the Normal Bacterial Flora of the Oral Cavity
journal, November 2005
- Aas, J. A.; Paster, B. J.; Stokes, L. N.
- Journal of Clinical Microbiology, Vol. 43, Issue 11
Oral Microbiome Profiles: 16S rRNA Pyrosequencing and Microarray Assay Comparison
journal, July 2011
- Ahn, Jiyoung; Yang, Liying; Paster, Bruce J.
- PLoS ONE, Vol. 6, Issue 7
Microbial shift and periodontitis: Microbial shift
journal, December 2010
- Berezow, Alex B.; Darveau, Richard P.
- Periodontology 2000, Vol. 55, Issue 1
In silico analysis of complete bacterial genomes: PCR, AFLP-PCR and endonuclease restriction
journal, January 2004
- Bikandi, J.; Millan, R. S.; Rementeria, A.
- Bioinformatics, Vol. 20, Issue 5
Obesity and pancreatic cancer: Overview of epidemiologic evidence and biologic mechanisms
journal, December 2011
- Bracci, Paige M.
- Molecular Carcinogenesis, Vol. 51, Issue 1
PyNAST: a flexible tool for aligning sequences to a template alignment
journal, November 2009
- Caporaso, J. G.; Bittinger, K.; Bushman, F. D.
- Bioinformatics, Vol. 26, Issue 2
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
journal, June 2010
- Caporaso, J. G.; Lauber, C. L.; Walters, W. A.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue Supplement_1
The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
journal, January 2010
- Chen, T.; Yu, W. -H.; Izard, J.
- Database, Vol. 2010, Issue 0
The Ribosomal Database Project (RDP-II): previewing a new autoaligner that allows regular updates and the new prokaryotic taxonomy
journal, January 2003
- Cole, J. R.
- Nucleic Acids Research, Vol. 31, Issue 1
Dynamics and associations of microbial community types across the human body
journal, April 2014
- Ding, Tao; Schloss, Patrick D.
- Nature, Vol. 509, Issue 7500
Search and clustering orders of magnitude faster than BLAST
journal, August 2010
- Edgar, Robert C.
- Bioinformatics, Vol. 26, Issue 19, p. 2460-2461
Associations between Periodontitis and Systemic Inflammatory Diseases: Response to Treatment
journal, September 2013
- El-Shinnawi, Una; Soory, Mena
- Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, Vol. 7, Issue 3
Leptotrichia species in human infections
journal, June 2008
- Eribe, Emenike Ribs K.; Olsen, Ingar
- Anaerobe, Vol. 14, Issue 3
Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
journal, October 2011
- Farrell, James J.; Zhang, Lei; Zhou, Hui
- Gut, Vol. 61, Issue 4
IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
journal, July 2007
- Feurino, Louis W.; Zhang, Yuqing; Bharadwaj, Uddalak
- Cancer Biology & Therapy, Vol. 6, Issue 7
A Prospective Study of Cigarette Smoking and the Risk of Pancreatic Cancer
journal, October 1996
- Fuchs, Charles S.
- Archives of Internal Medicine, Vol. 156, Issue 19
Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators
journal, January 2014
- Galimanas, Vaia; Hall, Michael; Singh, Natasha
- Microbiome, Vol. 2, Issue 1
The Human Microbiome: Our Second Genome
journal, September 2012
- Grice, Elizabeth A.; Segre, Julia A.
- Annual Review of Genomics and Human Genetics, Vol. 13, Issue 1
Mobile Microbiome: Oral Bacteria in Extra-oral Infections and Inflammation
journal, April 2013
- Han, Y. W.; Wang, X.
- Journal of Dental Research, Vol. 92, Issue 6
Diabetes, Smoking, Alcohol Use, and Family History of Cancer as Risk Factors for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis
journal, January 2015
- Haugvik, Sven-Petter; Hedenström, Per; Korsæth, Emilie
- Neuroendocrinology, Vol. 101, Issue 2
Bayesian community-wide culture-independent microbial source tracking
journal, July 2011
- Knights, Dan; Kuczynski, Justin; Charlson, Emily S.
- Nature Methods, Vol. 8, Issue 9
Experimental and analytical tools for studying the human microbiome
journal, December 2011
- Kuczynski, Justin; Lauber, Christian L.; Walters, William A.
- Nature Reviews Genetics, Vol. 13, Issue 1
Analysis of the salivary microbiome using culture-independent techniques
journal, January 2012
- Lazarevic, Vladimir; Whiteson, Katrine; Gaïa, Nadia
- Journal of Clinical Bioinformatics, Vol. 2, Issue 1
Pancreatic cancer
journal, March 2004
- Li, Donghui; Xie, Keping; Wolff, Robert
- The Lancet, Vol. 363, Issue 9414
Abstract 101: Pilot study of oral microbiome and risk of pancreatic cancer.
conference, November 2014
- Lin, I-Hsin; Wu, Jing; Cohen, Steven M.
- Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC, Epidemiology
Cancer risk in patients with type 2 diabetes mellitus and their relatives: Type 2 diabetes mellitus and cancer
journal, February 2015
- Liu, Xiangdong; Hemminki, Kari; Försti, Asta
- International Journal of Cancer, Vol. 137, Issue 4
The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects
journal, July 2005
- Mager, D. L.; Haffajee, A. D.; Devlin, P. M.
- Journal of Translational Medicine, Vol. 3, Issue 1
Risk of pancreatic adenocarcinoma in chronic pancreatitis
journal, December 2002
- Malka, D.
- Gut, Vol. 51, Issue 6
Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study
journal, September 2012
- Michaud, Dominique S.; Izard, Jacques; Wilhelm-Benartzi, Charlotte S.
- Gut, Vol. 62, Issue 12
A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals
journal, January 2007
- Michaud, Dominique S.; Joshipura, Kaumudi; Giovannucci, Edward
- JNCI: Journal of the National Cancer Institute, Vol. 99, Issue 2
Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
journal, March 2015
- Mitsuhashi, Kei; Nosho, Katsuhiko; Sukawa, Yasutaka
- Oncotarget, Vol. 6, Issue 9
The diagnostic role of saliva - A Review
journal, January 2010
- Mittal, S.; Bansal, V.; Garg, S.
- Journal of Clinical and Experimental Dentistry
Orthodontic bracket designs and their impact on microbial profile and periodontal disease: A clinical trial
journal, January 2014
- Moolya, NikeshN; Sharma, Rashmi; Shetty, Arvind
- Journal of Orthodontic Science, Vol. 3, Issue 4
Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set
journal, January 2002
- Hunter, Neil; Nadkarni, Mangala A.; Jacques, Nicholas A.
- Microbiology, Vol. 148, Issue 1
Cigarette Smoking and Other Lifestyle Factors in Relation to the Risk of Pancreatic Cancer Death: A Prospective Cohort Study in Japan
journal, November 2010
- Nakamura, K.; Nagata, C.; Wada, K.
- Japanese Journal of Clinical Oncology, Vol. 41, Issue 2
Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates.
journal, January 1994
- Persson, G. R.; Engel, D.; Whitney, C.
- Infection and Immunity, Vol. 62, Issue 3
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
journal, April 2009
- Price, M. N.; Dehal, P. S.; Arkin, A. P.
- Molecular Biology and Evolution, Vol. 26, Issue 7
The Personal Human Oral Microbiome Obscures the Effects of Treatment on Periodontal Disease
journal, January 2014
- Schwarzberg, Karen; Le, Rosalin; Bharti, Balambal
- PLoS ONE, Vol. 9, Issue 1
Real-time PCR (qPCR) primer design using free online software
journal, March 2011
- Thornton, Brenda; Basu, Chhandak
- Biochemistry and Molecular Biology Education, Vol. 39, Issue 2
EMPeror: a tool for visualizing high-throughput microbial community data
journal, November 2013
- Vázquez-Baeza, Yoshiki; Pirrung, Meg; Gonzalez, Antonio
- GigaScience, Vol. 2, Issue 1
Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
journal, January 2010
- Vrieling, Alina; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C.
- International Journal of Cancer
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
journal, May 2013
- Wang, Jinfeng; Qi, Ji; Zhao, Hui
- Scientific Reports, Vol. 3, Issue 1
Co-occurrence of anaerobic bacteria in colorectal carcinomas
journal, January 2013
- Warren, René L.; Freeman, Douglas J.; Pleasance, Stephen
- Microbiome, Vol. 1, Issue 1
DECIPHER, a Search-Based Approach to Chimera Identification for 16S rRNA Sequences
journal, November 2011
- Wright, Erik S.; Yilmaz, L. Safak; Noguera, Daniel R.
- Applied and Environmental Microbiology, Vol. 78, Issue 3
Compositional Stability of a Salivary Bacterial Population against Supragingival Microbiota Shift following Periodontal Therapy
journal, August 2012
- Yamanaka, Wataru; Takeshita, Toru; Shibata, Yukie
- PLoS ONE, Vol. 7, Issue 8
Defining the healthy "core microbiome" of oral microbial communities
journal, January 2009
- Zaura, Egija; Keijser, Bart JF; Huse, Susan M.
- BMC Microbiology, Vol. 9, Issue 1
Microbiota associated with type 2 diabetes and its related complications
journal, September 2013
- Zhang, Yong; Zhang, Heping
- Food Science and Human Wellness, Vol. 2, Issue 3-4
A prospective study of cigarette smoking and the risk of pancreatic cancer
journal, October 1996
- Fuchs, C. S.
- Archives of Internal Medicine, Vol. 156, Issue 19
Methods to Activate and Elucidate Complex Endogenous Sugar Metabolism in Yarrowia lipolytica
book, January 2021
- Ryu, Seunghyun; Trinh, Cong T.
- Methods in Molecular Biology
The Gut Microbiome in Autism: Study-Site Effects and Longitudinal Analysis of Behavior Change
journal, April 2021
- Fouquier, Jennifer; Moreno Huizar, Nancy; Donnelly, Jody
- mSystems, Vol. 6, Issue 2
A Prospective Study of Cigarette Smoking and the Risk of Pancreatic Cancer
journal, October 1996
- Fuchs, Charles S.
- Archives of Internal Medicine, Vol. 156, Issue 19
Real-time PCR (qPCR) primer design using free online software
journal, March 2011
- Thornton, Brenda; Basu, Chhandak
- Biochemistry and Molecular Biology Education, Vol. 39, Issue 2
Obesity and pancreatic cancer: Overview of epidemiologic evidence and biologic mechanisms
journal, December 2011
- Bracci, Paige M.
- Molecular Carcinogenesis, Vol. 51, Issue 1
A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States)
journal, September 1993
- Zheng, Wei; McLaughlin, Joseph K.; Gridley, Gloria
- Cancer Causes & Control, Vol. 4, Issue 5
Microbiota associated with type 2 diabetes and its related complications
journal, September 2013
- Zhang, Yong; Zhang, Heping
- Food Science and Human Wellness, Vol. 2, Issue 3-4
Inflammation and the development of pancreatic cancer
journal, May 2002
- Farrow, Buckminster; Evers, B. Mark
- Surgical Oncology, Vol. 10, Issue 4
Signs and symptoms of pancreatic cancer: a population-based case-control study in the San Francisco Bay area
journal, June 2004
- Holly, Elizabeth A.; Chaliha, Indranushi; Bracci, Paige M.
- Clinical Gastroenterology and Hepatology, Vol. 2, Issue 6
Dynamics and associations of microbial community types across the human body
journal, April 2014
- Ding, Tao; Schloss, Patrick D.
- Nature, Vol. 509, Issue 7500
Bayesian community-wide culture-independent microbial source tracking
journal, July 2011
- Knights, Dan; Kuczynski, Justin; Charlson, Emily S.
- Nature Methods, Vol. 8, Issue 9
Experimental and analytical tools for studying the human microbiome
journal, December 2011
- Kuczynski, Justin; Lauber, Christian L.; Walters, William A.
- Nature Reviews Genetics, Vol. 13, Issue 1
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
journal, May 2013
- Wang, Jinfeng; Qi, Ji; Zhao, Hui
- Scientific Reports, Vol. 3, Issue 1
PyNAST: a flexible tool for aligning sequences to a template alignment
journal, November 2009
- Caporaso, J. G.; Bittinger, K.; Bushman, F. D.
- Bioinformatics, Vol. 26, Issue 2
Search and clustering orders of magnitude faster than BLAST
journal, August 2010
- Edgar, Robert C.
- Bioinformatics, Vol. 26, Issue 19, p. 2460-2461
The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
journal, January 2010
- Chen, T.; Yu, W. -H.; Izard, J.
- Database, Vol. 2010, Issue 0
Cigarette Smoking and Other Lifestyle Factors in Relation to the Risk of Pancreatic Cancer Death: A Prospective Cohort Study in Japan
journal, November 2010
- Nakamura, K.; Nagata, C.; Wada, K.
- Japanese Journal of Clinical Oncology, Vol. 41, Issue 2
A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals
journal, January 2007
- Michaud, Dominique S.; Joshipura, Kaumudi; Giovannucci, Edward
- JNCI: Journal of the National Cancer Institute, Vol. 99, Issue 2
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
journal, April 2009
- Price, M. N.; Dehal, P. S.; Arkin, A. P.
- Molecular Biology and Evolution, Vol. 26, Issue 7
The Ribosomal Database Project (RDP-II): previewing a new autoaligner that allows regular updates and the new prokaryotic taxonomy
journal, January 2003
- Cole, J. R.
- Nucleic Acids Research, Vol. 31, Issue 1
Immune modulation of Prevotella intermedia colonization in squirrel monkeys.
journal, January 1991
- Clark, W. B.; Magnusson, I.; Beem, J. E.
- Infection and Immunity, Vol. 59, Issue 6
Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.
journal, January 1992
- Evans, R. T.; Klausen, B.; Sojar, H. T.
- Infection and Immunity, Vol. 60, Issue 7
Risk of pancreatic adenocarcinoma in chronic pancreatitis
journal, December 2002
- Malka, D.
- Gut, Vol. 51, Issue 6
Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
journal, October 2011
- Farrell, James J.; Zhang, Lei; Zhou, Hui
- Gut, Vol. 61, Issue 4
Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study
journal, September 2012
- Michaud, Dominique S.; Izard, Jacques; Wilhelm-Benartzi, Charlotte S.
- Gut, Vol. 62, Issue 12
Diabetes, Smoking, Alcohol Use, and Family History of Cancer as Risk Factors for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis
journal, January 2015
- Haugvik, Sven-Petter; Hedenström, Per; Korsæth, Emilie
- Neuroendocrinology, Vol. 101, Issue 2
Mobile Microbiome: Oral Bacteria in Extra-oral Infections and Inflammation
journal, April 2013
- Han, Y. W.; Wang, X.
- Journal of Dental Research, Vol. 92, Issue 6
Defining the healthy "core microbiome" of oral microbial communities
journal, January 2009
- Zaura, Egija; Keijser, Bart JF; Huse, Susan M.
- BMC Microbiology, Vol. 9, Issue 1
The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects
journal, July 2005
- Mager, D. L.; Haffajee, A. D.; Devlin, P. M.
- Journal of Translational Medicine, Vol. 3, Issue 1
Compositional Stability of a Salivary Bacterial Population against Supragingival Microbiota Shift following Periodontal Therapy
journal, August 2012
- Yamanaka, Wataru; Takeshita, Toru; Shibata, Yukie
- PLoS ONE, Vol. 7, Issue 8
Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
journal, March 2015
- Mitsuhashi, Kei; Nosho, Katsuhiko; Sukawa, Yasutaka
- Oncotarget, Vol. 6, Issue 9
Associations between Periodontitis and Systemic Inflammatory Diseases: Response to Treatment
journal, September 2013
- El-Shinnawi, Una; Soory, Mena
- Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, Vol. 7, Issue 3
Orthodontic bracket designs and their impact on microbial profile and periodontal disease: A clinical trial
journal, January 2014
- Moolya, NikeshN; Sharma, Rashmi; Shetty, Arvind
- Journal of Orthodontic Science, Vol. 3, Issue 4
IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
journal, July 2007
- Feurino, Louis W.; Zhang, Yuqing; Bharadwaj, Uddalak
- Cancer Biology & Therapy, Vol. 6, Issue 7
The diagnostic role of saliva - A Review
journal, January 2010
- Mittal, S.; Bansal, V.; Garg, S.
- Journal of Clinical and Experimental Dentistry
Characterization of Salivary Microbiome in Patients with Pancreatic Cancer
dataset, January 2015
- Kelley, Scott
- figshare
Works referencing / citing this record:
Oral microbial community composition is associated with pancreatic cancer: A case‐control study in Iran
journal, November 2019
- Vogtmann, Emily; Han, Yongli; Caporaso, J. Gregory
- Cancer Medicine, Vol. 9, Issue 2
Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects: Lower airway microbiome and lung cancer
journal, November 2017
- Liu, Hai-Xia; Tao, Li-Li; Zhang, Jing
- International Journal of Cancer, Vol. 142, Issue 4
Salivary biomarkers in cancer detection
journal, December 2016
- Wang, Xiaoqian; Kaczor-Urbanowicz, Karolina Elżbieta; Wong, David T. W.
- Medical Oncology, Vol. 34, Issue 1
Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity
journal, January 2017
- Hall, Michael W.; Singh, Natasha; Ng, Kester F.
- npj Biofilms and Microbiomes, Vol. 3, Issue 1
Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
journal, May 2018
- Cani, Patrice D.; Jordan, Benedicte F.
- Nature Reviews Gastroenterology & Hepatology, Vol. 15, Issue 11
Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker
journal, April 2018
- Iwasawa, Kentaro; Suda, Wataru; Tsunoda, Tomoyuki
- Scientific Reports, Vol. 8, Issue 1
Leptotrichia species in human infections II
journal, January 2017
- Eribe, Emenike R. K.; Olsen, Ingar
- Journal of Oral Microbiology, Vol. 9, Issue 1
Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls
journal, January 2019
- Lu, Haifeng; Ren, Zhigang; Li, Ang
- Journal of Oral Microbiology, Vol. 11, Issue 1
Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study
journal, October 2016
- Fan, Xiaozhou; Alekseyenko, Alexander V.; Wu, Jing
- Gut, Vol. 67, Issue 1
The oral microbiota in colorectal cancer is distinctive and predictive
journal, October 2017
- Flemer, Burkhardt; Warren, Ryan D.; Barrett, Maurice P.
- Gut, Vol. 67, Issue 8
Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders
journal, January 2018
- Pagliari, D.; Saviano, A.; Newton, E. E.
- Mediators of Inflammation, Vol. 2018
Microbial Diversity of Chronic Wound and Successful Management of Traditional Chinese Medicine
journal, July 2018
- Wu, Minfeng; Li, Yan; Guo, Dongjie
- Evidence-Based Complementary and Alternative Medicine, Vol. 2018
The potential role of P.gingivalis in gastrointestinal cancer: a mini review
journal, September 2019
- Liu, Xiao-bo; Gao, Zi-ye; Sun, Chuan-tao
- Infectious Agents and Cancer, Vol. 14, Issue 1
High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients
journal, August 2019
- Zhang, Nan; Zhang, Hongbo; Yu, Yanhui
- Parasites & Vectors, Vol. 12, Issue 1
Beyond Head and Neck Cancer: The Relationship Between Oral Microbiota and Tumour Development in Distant Organs
journal, June 2019
- Mascitti, Marco; Togni, Lucrezia; Troiano, Giuseppe
- Frontiers in Cellular and Infection Microbiology, Vol. 9
Elevated Polyamines in Saliva of Pancreatic Cancer
journal, February 2018
- Asai, Yasutsugu; Itoi, Takao; Sugimoto, Masahiro
- Cancers, Vol. 10, Issue 2
Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity
journal, September 2016
- Rapado-González, Óscar; Majem, Blanca; Muinelo-Romay, Laura
- International Journal of Molecular Sciences, Vol. 17, Issue 9
Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance
journal, October 2018
- Cascetta, Priscilla; Cavaliere, Alessandro; Piro, Geny
- International Journal of Molecular Sciences, Vol. 19, Issue 11
Characterization of the salivary microbiome in people with obesity
journal, January 2018
- Wu, Yujia; Chi, Xiaopei; Zhang, Qian
- PeerJ, Vol. 6
Elevated Polyamines in Saliva of Pancreatic Cancer
journal, January 2018
- Asai, Yasutsugu; Itoi, Takao; Sugimoto, Masahiro
- Cancers, Vol. 10, Issue 43
Oral microbial community composition is associated with pancreatic cancer: A case-control study in Iran
text, January 2020
- Vogtmann, Emily; Han, Yongli; Caporaso, J. Gregory
- ETH Zurich
Oral microbial community composition is associated with pancreatic cancer: A case‐control study in Iran
journal, November 2019
- Vogtmann, Emily; Han, Yongli; Caporaso, J. Gregory
- Cancer Medicine, Vol. 9, Issue 2
Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker
journal, April 2018
- Iwasawa, Kentaro; Suda, Wataru; Tsunoda, Tomoyuki
- Scientific Reports, Vol. 8, Issue 1
Leptotrichia species in human infections II
journal, January 2017
- Eribe, Emenike R. K.; Olsen, Ingar
- Journal of Oral Microbiology, Vol. 9, Issue 1
Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls
journal, January 2019
- Lu, Haifeng; Ren, Zhigang; Li, Ang
- Journal of Oral Microbiology, Vol. 11, Issue 1
Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) formalin fixed paraffin-embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis
journal, August 2020
- Masi, Andrea C.; Oppong, Yaa E. A.; Haugk, Beate
- Gut, Vol. 70, Issue 5
Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders
journal, January 2018
- Pagliari, D.; Saviano, A.; Newton, E. E.
- Mediators of Inflammation, Vol. 2018
Microbial Diversity of Chronic Wound and Successful Management of Traditional Chinese Medicine
journal, July 2018
- Wu, Minfeng; Li, Yan; Guo, Dongjie
- Evidence-Based Complementary and Alternative Medicine, Vol. 2018
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
journal, December 2019
- Wang, Yicheng; Yang, Gang; You, Lei
- Molecular Cancer, Vol. 18, Issue 1
High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients
journal, August 2019
- Zhang, Nan; Zhang, Hongbo; Yu, Yanhui
- Parasites & Vectors, Vol. 12, Issue 1
Beyond Head and Neck Cancer: The Relationship Between Oral Microbiota and Tumour Development in Distant Organs
journal, June 2019
- Mascitti, Marco; Togni, Lucrezia; Troiano, Giuseppe
- Frontiers in Cellular and Infection Microbiology, Vol. 9
Elevated Polyamines in Saliva of Pancreatic Cancer
journal, February 2018
- Asai, Yasutsugu; Itoi, Takao; Sugimoto, Masahiro
- Cancers, Vol. 10, Issue 2
Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity
journal, September 2016
- Rapado-González, Óscar; Majem, Blanca; Muinelo-Romay, Laura
- International Journal of Molecular Sciences, Vol. 17, Issue 9
Salivary biomarkers for diagnosis of systemic diseases and malignant tumors. A systematic review
journal, January 2020
- Meleti, M.; Cassi, D.; Vescovi, P.
- Medicina Oral Patología Oral y Cirugia Bucal
Characterization of the salivary microbiome in people with obesity
journal, January 2018
- Wu, Yujia; Chi, Xiaopei; Zhang, Qian
- PeerJ, Vol. 6