Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals
Abstract
A novel nanocomposite scaffold was developed by homogeneous deposition of hydroxyapatite (HAP) on a cellulose nanocrystals (CNCs) matrix suspended in a simulated body fluid (SBF). By adjusting the pH of the SBF, the HAP content in the nanocomposite could be controlled between 15 wt% and 47 wt%. Physical and chemical characteristics of the nanocomposites were analyzed by SEM, FTIR, XRD, SAED, and TEM, which confirmed the successful incorporation of HAP onto the CNCs. The nanocomposites were then freeze-casted into porous scaffolds by different solidification technologies (i.e., directional freezing (DF), plunging in liquid N2 (PL) or in a -20 °C freezer (FZ)) followed by lyophilization. Compression testing of the HAP/CNCs foams indicated that DF caused significant improvement in mechanical properties due to the specific orientation and anisotropic porous structure compared to conventional freezing methods such as PL and FZ. Moreover, the scaffold with high HAP content exhibited improved mechanical and thermal properties, which holds potential for application in bone tissue engineering.
- Authors:
-
[2];
[3];
[4];
[2]
- Nanjing Forestry Univ., Nanjing (China); Univ. of Tennessee, Knoxville, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States)
- Nanjing Forestry Univ., Nanjing (China)
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD); Doctorate Fellowship Foundation of Nanjing Forestry Univ.
- OSTI Identifier:
- 1507845
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- RSC Advances
- Additional Journal Information:
- Journal Volume: 9; Journal Issue: 10; Journal ID: ISSN 2046-2069
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Huang, Chen, Bhagia, Samarthya, Hao, Naijia, Meng, Xianzhi, Liang, Luna, Yong, Qiang, and Ragauskas, Arthur J. Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals. United States: N. p., 2019.
Web. doi:10.1039/c8ra09523j.
Huang, Chen, Bhagia, Samarthya, Hao, Naijia, Meng, Xianzhi, Liang, Luna, Yong, Qiang, & Ragauskas, Arthur J. Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals. United States. https://doi.org/10.1039/c8ra09523j
Huang, Chen, Bhagia, Samarthya, Hao, Naijia, Meng, Xianzhi, Liang, Luna, Yong, Qiang, and Ragauskas, Arthur J. Fri .
"Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals". United States. https://doi.org/10.1039/c8ra09523j. https://www.osti.gov/servlets/purl/1507845.
@article{osti_1507845,
title = {Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals},
author = {Huang, Chen and Bhagia, Samarthya and Hao, Naijia and Meng, Xianzhi and Liang, Luna and Yong, Qiang and Ragauskas, Arthur J.},
abstractNote = {A novel nanocomposite scaffold was developed by homogeneous deposition of hydroxyapatite (HAP) on a cellulose nanocrystals (CNCs) matrix suspended in a simulated body fluid (SBF). By adjusting the pH of the SBF, the HAP content in the nanocomposite could be controlled between 15 wt% and 47 wt%. Physical and chemical characteristics of the nanocomposites were analyzed by SEM, FTIR, XRD, SAED, and TEM, which confirmed the successful incorporation of HAP onto the CNCs. The nanocomposites were then freeze-casted into porous scaffolds by different solidification technologies (i.e., directional freezing (DF), plunging in liquid N2 (PL) or in a -20 °C freezer (FZ)) followed by lyophilization. Compression testing of the HAP/CNCs foams indicated that DF caused significant improvement in mechanical properties due to the specific orientation and anisotropic porous structure compared to conventional freezing methods such as PL and FZ. Moreover, the scaffold with high HAP content exhibited improved mechanical and thermal properties, which holds potential for application in bone tissue engineering.},
doi = {10.1039/c8ra09523j},
journal = {RSC Advances},
number = 10,
volume = 9,
place = {United States},
year = {Fri Feb 15 00:00:00 EST 2019},
month = {Fri Feb 15 00:00:00 EST 2019}
}
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Cited by: 25 works
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Figures / Tables:
Fig. 1: The SEM images of CNCs before and after hydroxyapatite (HAP) coating. (a) Pure CNCs; (b) at SBF of pH 6.0; (c) at SBF pH 7.4; (d) at SBF pH 8.5.
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Works referencing / citing this record:
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