Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C–H) with indoles (sp2 C–H) using a heterogeneous mesoporous manganese oxide catalyst [Mesoporous manganese oxide catalyzed cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C–H) with indoles (sp2 C–H)]

Dutta, B.; Sharma, Vinit K.; Sassu, N.; Dang, Y.; Weerakkody, C.; Macharia, J.; Miao, R.; Howell, A. R.; Suib, Steven L.

doi:10.1039/C7GC01919J

Title: Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp³ C–H) with indoles (sp² C–H) using a heterogeneous mesoporous manganese oxide catalyst [Mesoporous manganese oxide catalyzed cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp³ C–H) with indoles (sp² C–H)]

Journal Article · Tue Sep 26 20:00:00 EDT 2017 · Green Chemistry

DOI: https://doi.org/10.1039/C7GC01919J · OSTI ID:1456820

Dutta, B. ^[1];

^[2]; Sassu, N. ^[1]; Dang, Y. ^[1]; Weerakkody, C. ^[1]; Macharia, J. ^[1]; Miao, R. ^[1]; Howell, A. R. ^[1];

^[1]

Univ. of Connecticut, Storrs, CT (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Here, we disclose a novel, heterogeneous catalytic approach for selective coupling of C1 of N-aryltetrahydroisoquinolines with C3 of indoles in the presence of mesoporous manganese oxides. Our work involves a detailed mechanistic investigation of the reaction on the catalyst surface, backed by DFT computational studies, to understand the superior catalytic activity of manganese oxides.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1456820

Journal Information:: Green Chemistry, Journal Name: Green Chemistry Journal Issue: 22 Vol. 19; ISSN GRCHFJ; ISSN 1463-9262

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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