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Title: Routine Production of 89Zr Using an Automated Module

Abstract

89Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t 1/2 = 3.27 days) is well-suited for in vivo targeting of macromolecules and nanoparticles to cell surface antigens expressed by cancer cells. Furthermore, 89Zr emits a low-energy positron (E β+,mean = 0.40 MeV), which is favorable for high spatial resolution in PET, with an adequate branching ratio for positron emission (BR = 23%). The demand for 89Zr for research purposes is increasing; however, 89Zr also emits significant gamma radiation (Γ 15 keV = 6.6 R∙cm 2/mCi∙h), which makes producing large amounts of this isotope by hand unrealistic from a radiation safety standpoint. Fortunately, a straightforward method exists for production of 89Zr by bombarding a natural Y target in a biomedical cyclotron and then separation of 89Zr from the target material by column chromatography. The chemical separation in this method lends itself to remote processing using an automated module placed inside a hot cell. In this work, we have designed, built and commissioned a module that has performed the chemical separation of 89Zr safely and routinely, atmore » activities in excess of 50 mCi, with radionuclidic purity > 99.9% and satisfactory effective specific activity (ESA).« less

Authors:
 [1];  [2];  [2];  [2];  [2];  [3];  [1]
  1. Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Biomedical Engineering
  2. Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology
  3. Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Physics
Publication Date:
Research Org.:
Washington Univ., St. Louis, MO (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26); National Inst. of Health (NIH) (United States)
OSTI Identifier:
1454864
Grant/Contract Number:  
NA0000979; SC0008657; T32EB014855-01
Resource Type:
Accepted Manuscript
Journal Name:
Applied Sciences
Additional Journal Information:
Journal Volume: 3; Journal Issue: 3; Journal ID: ISSN 2076-3417
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPE AND RADIATION SOURCES; 89Zr; isotope production; automation; cyclotron; positron emission tomography

Citation Formats

Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, and Lapi, Suzanne. Routine Production of 89Zr Using an Automated Module. United States: N. p., 2013. Web. doi:10.3390/app3030593.
Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, & Lapi, Suzanne. Routine Production of 89Zr Using an Automated Module. United States. doi:10.3390/app3030593.
Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, and Lapi, Suzanne. Fri . "Routine Production of 89Zr Using an Automated Module". United States. doi:10.3390/app3030593. https://www.osti.gov/servlets/purl/1454864.
@article{osti_1454864,
title = {Routine Production of 89Zr Using an Automated Module},
author = {Wooten, A. and Madrid, Evelyn and Schweitzer, Gordon and Lawrence, Luke and Mebrahtu, Efrem and Lewis, Benjamin and Lapi, Suzanne},
abstractNote = {89Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t1/2 = 3.27 days) is well-suited for in vivo targeting of macromolecules and nanoparticles to cell surface antigens expressed by cancer cells. Furthermore, 89Zr emits a low-energy positron (Eβ+,mean = 0.40 MeV), which is favorable for high spatial resolution in PET, with an adequate branching ratio for positron emission (BR = 23%). The demand for 89Zr for research purposes is increasing; however, 89Zr also emits significant gamma radiation (Γ15 keV = 6.6 R∙cm2/mCi∙h), which makes producing large amounts of this isotope by hand unrealistic from a radiation safety standpoint. Fortunately, a straightforward method exists for production of 89Zr by bombarding a natural Y target in a biomedical cyclotron and then separation of 89Zr from the target material by column chromatography. The chemical separation in this method lends itself to remote processing using an automated module placed inside a hot cell. In this work, we have designed, built and commissioned a module that has performed the chemical separation of 89Zr safely and routinely, at activities in excess of 50 mCi, with radionuclidic purity > 99.9% and satisfactory effective specific activity (ESA).},
doi = {10.3390/app3030593},
journal = {Applied Sciences},
number = 3,
volume = 3,
place = {United States},
year = {2013},
month = {7}
}

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Cited by: 23 works
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Works referenced in this record:

Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89
journal, December 1992

  • Meijs, Wilma E.; Herscheid, Jacobus D. M.; Haisma, Hidde J.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 12
  • DOI: 10.1016/0883-2889(92)90170-J

Standardized methods for the production of high specific-activity zirconium-89
journal, October 2009


Investigations of 89Y(p,x)86,88,89gZr, 86m+g,87g,87m,88gY, 85gSr, and 84gRb nuclear processes up to 42MeV
journal, January 2012

  • Khandaker, Mayeen Uddin; Kim, Kwangsoo; Lee, Man-Woo
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 271
  • DOI: 10.1016/j.nimb.2011.11.009

Survey of ( p ,   n ) Reactions at 12 Mev
journal, December 1955


Nuclear reactions in Rb, Sr, Y, and Zr targets
journal, September 1982


Reactions (p, pn), (p, 2n) and (p, n) on 89Y induced by high-energy protons
journal, June 1966


Excitation Functions of Proton Induced Reactions on 89Y and 93Nb with Emphasis on the Production of Selected Radio-Zirconiums
journal, August 2011

  • Steyn, G. F.; Vermeulen, C.; Szelecsenyi, F.
  • Journal of the Korean Physical Society, Vol. 59, Issue 2(3)
  • DOI: 10.3938/jkps.59.1991

Unconventional Nuclides for Radiopharmaceuticals
journal, January 2010

  • Holland, Jason P.; Williamson, Matthew J.; Lewis, Jason S.
  • Molecular Imaging, Vol. 9, Issue 1
  • DOI: 10.2310/7290.2010.00008

Simultaneous production of 89Zr and 90,91m,92mNb in α-particle activated yttrium and their subsequent separation by HDEHP
journal, July 1997


The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86
journal, April 2011

  • Ikotun, Oluwatayo F.; Lapi, Suzanne E.
  • Future Medicinal Chemistry, Vol. 3, Issue 5
  • DOI: 10.4155/fmc.11.14

Radioimmunoimaging with Longer-Lived Positron-Emitting Radionuclides: Potentials and Challenges
journal, May 2009

  • Nayak, Tapan K.; Brechbiel, Martin W.
  • Bioconjugate Chemistry, Vol. 20, Issue 5
  • DOI: 10.1021/bc800299f

PET Tracers Based on Zirconium-89
journal, April 2011


Fully automated production of iodine-124 using a vertical beam
journal, January 2011


Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies
journal, January 2010


Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr
journal, January 2009


Production of 88,89Zr by proton induced activation of natY and separation by SLX and LLX
journal, June 2009

  • Dutta, Binita; Maiti, Moumita; Lahiri, Susanta
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 281, Issue 3
  • DOI: 10.1007/s10967-009-0051-5

An automated method for regular productions of copper-64 for PET radiopharmaceuticals
journal, April 2010


Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT
journal, June 2011


Immuno-PET: A Navigator in Monoclonal Antibody Development and Applications
journal, December 2007



journal, September 2011


PET imaging with 89Zr: From radiochemistry to the clinic
journal, January 2013


Pre-equilibrium processes in (p,n) reactions
journal, February 1973


Image-Quality Assessment for Several Positron Emitters Using the NEMA NU 4-2008 Standards in the Siemens Inveon Small-Animal PET Scanner
journal, March 2010


Production and purification of 89Zr, a potential PET antibody label
journal, January 1990

  • Dejesus, O. T.; Nickles, R. J.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 8
  • DOI: 10.1016/0883-2889(90)90030-K

Manganese-52m for direct application: A new 52Fe/52mMn generator based on a hydroxamate resin
journal, June 1983

  • Herscheid, Jacobus D. M.; Vos, Cornelis M.; Hoekstra, Arend
  • The International Journal of Applied Radiation and Isotopes, Vol. 34, Issue 6
  • DOI: 10.1016/0020-708X(83)90147-3

Preparation, properties and analytical application of silica with chemically grafted hydroxamic acid groups
journal, January 1989


Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease
journal, May 2010

  • Wadas, Thaddeus J.; Wong, Edward H.; Weisman, Gary R.
  • Chemical Reviews, Vol. 110, Issue 5
  • DOI: 10.1021/cr900325h

( p ,   xn ) and ( p ,   pxn ) Reactions of Yttrium-89 with 5-85-MeV Protons
journal, April 1966


89Zr-PET Radiochemistry in the Development and Application of Therapeutic Monoclonal Antibodies and Other Biologicals]]>
journal, March 2013

  • Vugts, Danielle J.; Visser, Gerard W. M.; van Dongen, Guus A. M. S.
  • Current Topics in Medicinal Chemistry, Vol. 13, Issue 4
  • DOI: 10.2174/1568026611313040005

Positive Progress in ImmunoPET—Not Just a Coincidence
journal, June 2010

  • McCabe, Katelyn E.; Wu, Anna M.
  • Cancer Biotherapy and Radiopharmaceuticals, Vol. 25, Issue 3
  • DOI: 10.1089/cbr.2010.0776

Review on Production of 89Zr in a Medical Cyclotron for PET Radiopharmaceuticals
journal, January 2013

  • Kasbollah, A.; Eu, P.; Cowell, S.
  • Journal of Nuclear Medicine Technology, Vol. 41, Issue 1
  • DOI: 10.2967/jnmt.112.111377

Study of ( p , x n ) Reactions at 400 MeV
journal, February 1969


Exposure rate Constants and lead Shielding Values for over 1,100 Radionuclides
journal, January 2012


A computerized compact module for separation of 99mTc-radionuclide from molybdenum
journal, November 2012


Interaction of Yttrium with Protons of Energy between 60 and 240 Mev
journal, September 1959


Semi-automated 86Y purification using a three-column system
journal, February 2004


Immuno-Positron Emission Tomography: Shedding Light on Clinical Antibody Therapy
journal, August 2010

  • van Dongen, Guus A. M. S.; Vosjan, Maria J. W. D.
  • Cancer Biotherapy and Radiopharmaceuticals, Vol. 25, Issue 4
  • DOI: 10.1089/cbr.2010.0812

Production of no-carrier-added zirconium-89 for positron emission tomography
journal, January 1991

  • Zweit, J.; Downey, S.; Sharma, H. L.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 42, Issue 2
  • DOI: 10.1016/0883-2889(91)90074-B

Cross sections for the production of residual nuclides by low- and medium-energy protons from the target elements C, N, O, Mg, Al, Si, Ca, Ti, V, Mn, Fe, Co, Ni, Cu, Sr, Y, Zr, Nb, Ba and Au
journal, July 1997

  • Michel, R.; Bodemann, R.; Busemann, H.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 129, Issue 2
  • DOI: 10.1016/S0168-583X(97)00213-9

Radiometal-Labeled Agents (Non-Technetium) for Diagnostic Imaging
journal, September 1999

  • Anderson, Carolyn J.; Welch, Michael J.
  • Chemical Reviews, Vol. 99, Issue 9, p. 2219-2234
  • DOI: 10.1021/cr980451q

A semi-automated system for the routine production of copper-64
journal, August 2012


Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter
journal, December 1994

  • Meijs, Wilma E.; Herscheid, Jacobus D. M.; Haisma, Hidde J.
  • Applied Radiation and Isotopes, Vol. 45, Issue 12
  • DOI: 10.1016/0969-8043(94)90029-9

Experimental studies on excitation functions of the proton-induced activation reactions on yttrium
journal, September 2005