Routine Production of 89Zr Using an Automated Module
Abstract
89Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t1/2 = 3.27 days) is well-suited for in vivo targeting of macromolecules and nanoparticles to cell surface antigens expressed by cancer cells. Furthermore, 89Zr emits a low-energy positron (Eβ+,mean = 0.40 MeV), which is favorable for high spatial resolution in PET, with an adequate branching ratio for positron emission (BR = 23%). The demand for 89Zr for research purposes is increasing; however, 89Zr also emits significant gamma radiation (Γ15 keV = 6.6 R∙cm2/mCi∙h), which makes producing large amounts of this isotope by hand unrealistic from a radiation safety standpoint. Fortunately, a straightforward method exists for production of 89Zr by bombarding a natural Y target in a biomedical cyclotron and then separation of 89Zr from the target material by column chromatography. The chemical separation in this method lends itself to remote processing using an automated module placed inside a hot cell. In this work, we have designed, built and commissioned a module that has performed the chemical separation of 89Zr safely and routinely, at activities in excess ofmore »
- Authors:
-
- Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Biomedical Engineering
- Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology
- Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Physics
- Publication Date:
- Research Org.:
- Washington Univ., St. Louis, MO (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Nuclear Physics (NP); National Inst. of Health (NIH) (United States)
- OSTI Identifier:
- 1454864
- Grant/Contract Number:
- NA0000979; SC0008657; T32EB014855-01
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Applied Sciences
- Additional Journal Information:
- Journal Volume: 3; Journal Issue: 3; Journal ID: ISSN 2076-3417
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 07 ISOTOPE AND RADIATION SOURCES; 89Zr; isotope production; automation; cyclotron; positron emission tomography
Citation Formats
Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, and Lapi, Suzanne. Routine Production of 89Zr Using an Automated Module. United States: N. p., 2013.
Web. doi:10.3390/app3030593.
Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, & Lapi, Suzanne. Routine Production of 89Zr Using an Automated Module. United States. https://doi.org/10.3390/app3030593
Wooten, A., Madrid, Evelyn, Schweitzer, Gordon, Lawrence, Luke, Mebrahtu, Efrem, Lewis, Benjamin, and Lapi, Suzanne. Fri .
"Routine Production of 89Zr Using an Automated Module". United States. https://doi.org/10.3390/app3030593. https://www.osti.gov/servlets/purl/1454864.
@article{osti_1454864,
title = {Routine Production of 89Zr Using an Automated Module},
author = {Wooten, A. and Madrid, Evelyn and Schweitzer, Gordon and Lawrence, Luke and Mebrahtu, Efrem and Lewis, Benjamin and Lapi, Suzanne},
abstractNote = {89Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t1/2 = 3.27 days) is well-suited for in vivo targeting of macromolecules and nanoparticles to cell surface antigens expressed by cancer cells. Furthermore, 89Zr emits a low-energy positron (Eβ+,mean = 0.40 MeV), which is favorable for high spatial resolution in PET, with an adequate branching ratio for positron emission (BR = 23%). The demand for 89Zr for research purposes is increasing; however, 89Zr also emits significant gamma radiation (Γ15 keV = 6.6 R∙cm2/mCi∙h), which makes producing large amounts of this isotope by hand unrealistic from a radiation safety standpoint. Fortunately, a straightforward method exists for production of 89Zr by bombarding a natural Y target in a biomedical cyclotron and then separation of 89Zr from the target material by column chromatography. The chemical separation in this method lends itself to remote processing using an automated module placed inside a hot cell. In this work, we have designed, built and commissioned a module that has performed the chemical separation of 89Zr safely and routinely, at activities in excess of 50 mCi, with radionuclidic purity > 99.9% and satisfactory effective specific activity (ESA).},
doi = {10.3390/app3030593},
journal = {Applied Sciences},
number = 3,
volume = 3,
place = {United States},
year = {Fri Jul 12 00:00:00 EDT 2013},
month = {Fri Jul 12 00:00:00 EDT 2013}
}
Web of Science
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