Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks
Abstract
Complex 3D organizations of materials represent ubiquitous structural motifs found in the most sophisticated forms of matter, the most notable of which are in life-sustaining hierarchical structures found in biology, but where simpler examples also exist as dense multilayered constructs in high-performance electronics. Each class of system evinces specific enabling forms of assembly to establish their functional organization at length scales not dissimilar to tissue-level constructs. Furthermore, this study describes materials and means of assembly that extend and join these disparate systems—schemes for the functional integration of soft and biological materials with synthetic 3D microscale, open frameworks that can leverage the most advanced forms of multilayer electronic technologies, including device-grade semiconductors such as monocrystalline silicon. Cellular migration behaviors, temporal dependencies of their growth, and contact guidance cues provided by the nonplanarity of these frameworks illustrate design criteria useful for their functional integration with living matter (e.g., NIH 3T3 fibroblast and primary rat dorsal root ganglion cell cultures).
- Publication Date:
- Research Org.:
- Univ. of Illinois at Urbana-Champaign, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1875126
- Alternate Identifier(s):
- OSTI ID: 1389095
- Grant/Contract Number:
- FG02-07ER46471; DE‐FG02‐07ER46471
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Advanced Biosystems
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 9; Journal ID: ISSN 2366-7478
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 3D scaffolds; cellular contact guidance; compressive-assembly; direct ink writing; hydrogels
Citation Formats
McCracken, Joselle M., Xu, Sheng, Badea, Adina, Jang, Kyung‐In, Yan, Zheng, Wetzel, David J., Nan, Kewang, Lin, Qing, Han, Mengdi, Anderson, Mikayla A., Lee, Jung Woo, Wei, Zijun, Pharr, Matt, Wang, Renhan, Su, Jessica, Rubakhin, Stanislav S., Sweedler, Jonathan V., Rogers, John A., and Nuzzo, Ralph G. Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks. United States: N. p., 2017.
Web. doi:10.1002/adbi.201700068.
McCracken, Joselle M., Xu, Sheng, Badea, Adina, Jang, Kyung‐In, Yan, Zheng, Wetzel, David J., Nan, Kewang, Lin, Qing, Han, Mengdi, Anderson, Mikayla A., Lee, Jung Woo, Wei, Zijun, Pharr, Matt, Wang, Renhan, Su, Jessica, Rubakhin, Stanislav S., Sweedler, Jonathan V., Rogers, John A., & Nuzzo, Ralph G. Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks. United States. https://doi.org/10.1002/adbi.201700068
McCracken, Joselle M., Xu, Sheng, Badea, Adina, Jang, Kyung‐In, Yan, Zheng, Wetzel, David J., Nan, Kewang, Lin, Qing, Han, Mengdi, Anderson, Mikayla A., Lee, Jung Woo, Wei, Zijun, Pharr, Matt, Wang, Renhan, Su, Jessica, Rubakhin, Stanislav S., Sweedler, Jonathan V., Rogers, John A., and Nuzzo, Ralph G. Mon .
"Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks". United States. https://doi.org/10.1002/adbi.201700068. https://www.osti.gov/servlets/purl/1875126.
@article{osti_1875126,
title = {Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks},
author = {McCracken, Joselle M. and Xu, Sheng and Badea, Adina and Jang, Kyung‐In and Yan, Zheng and Wetzel, David J. and Nan, Kewang and Lin, Qing and Han, Mengdi and Anderson, Mikayla A. and Lee, Jung Woo and Wei, Zijun and Pharr, Matt and Wang, Renhan and Su, Jessica and Rubakhin, Stanislav S. and Sweedler, Jonathan V. and Rogers, John A. and Nuzzo, Ralph G.},
abstractNote = {Complex 3D organizations of materials represent ubiquitous structural motifs found in the most sophisticated forms of matter, the most notable of which are in life-sustaining hierarchical structures found in biology, but where simpler examples also exist as dense multilayered constructs in high-performance electronics. Each class of system evinces specific enabling forms of assembly to establish their functional organization at length scales not dissimilar to tissue-level constructs. Furthermore, this study describes materials and means of assembly that extend and join these disparate systems—schemes for the functional integration of soft and biological materials with synthetic 3D microscale, open frameworks that can leverage the most advanced forms of multilayer electronic technologies, including device-grade semiconductors such as monocrystalline silicon. Cellular migration behaviors, temporal dependencies of their growth, and contact guidance cues provided by the nonplanarity of these frameworks illustrate design criteria useful for their functional integration with living matter (e.g., NIH 3T3 fibroblast and primary rat dorsal root ganglion cell cultures).},
doi = {10.1002/adbi.201700068},
journal = {Advanced Biosystems},
number = 9,
volume = 1,
place = {United States},
year = {Mon Jul 31 00:00:00 EDT 2017},
month = {Mon Jul 31 00:00:00 EDT 2017}
}
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