Synthesis of 2H- and 13C-substituted dithanes

Martinez, Rodolfo A; Alvarez, Marc A; Unkefer, Clifford J

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Title: Synthesis of 2H- and 13C-substituted dithanes

Abstract

The present invention is directed to labeled compounds, [2-.sup.13 C]dithiane wherein the .sup.13 C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-.sup.13 C]dithiane wherein the .sup.13 C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., [.sup.2 H.sub.1-2, .sup.13 C]methanol (arylthio)-, acetates wherein the .sup.13 C atom is directly bonded to exactly one or two deuterium atoms.

Inventors:

Martinez, Rodolfo A ^[1]; Alvarez, Marc A ^[1]; Silks, III, Louis A. ^[2]; Unkefer, Clifford J ^[3]

Santa Fe, NM
(Los Alamos, NM)
Los Alamos, NM

Issue Date:: Wed Jan 01 00:00:00 EST 2003

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

OSTI Identifier:: 875140

Patent Number(s):: 6541671

Assignee:: The Regents of the University of California (Los Alamos, NM)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B2200/05 - Isotopically modified compounds, e.g. labelled

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C319/14 - of sulfides
C07C323/12 - the carbon skeleton being acyclic and saturated

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/54373 - {involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings}
G01N33/5438 - {Electrodes}
G01N33/54386 - {Analytical elements}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S435/808 - Optical sensing apparatus
Y10S435/966 - involving an enzyme system with high turnover rate or complement magnified assay, e.g. multi-enzyme systems
Y10S436/805 - Optical property
Y10S436/806 - Electrical property or magnetic property
Y10S436/808 - Automated or kit
Y10S436/823 - Immunogenic carrier or carrier per se
Y10S530/811 - Peptides or proteins is immobilized on, or in, an inorganic carrier
Y10S530/812 - Peptides or proteins is immobilized on, or in, an organic carrier

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: synthesis; 2h-; 13c-substituted; dithanes; directed; labeled; compounds; 2-sup13; cdithiane; sup13; atom; directly; bonded; deuterium; atoms; processes; preparing; sup2; hsub1-2; cmethanol; arylthio-; acetates; exactly; labeled compounds; /999/424/

Citation Formats


                    Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., and Unkefer, Clifford J. Synthesis of 2H- and 13C-substituted dithanes.  United States: N. p., 2003. 
        Web.

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                    Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., & Unkefer, Clifford J. Synthesis of 2H- and 13C-substituted dithanes.  United States.

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                    Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., and Unkefer, Clifford J. Wed .  
        "Synthesis of 2H- and 13C-substituted dithanes".  United States.  https://www.osti.gov/servlets/purl/875140.

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@article{osti_875140,

  title        = {Synthesis of 2H- and 13C-substituted dithanes},

  author       = {Martinez, Rodolfo A and Alvarez, Marc A and Silks, III, Louis A. and Unkefer, Clifford J},

  abstractNote = {The present invention is directed to labeled compounds, [2-.sup.13 C]dithiane wherein the .sup.13 C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-.sup.13 C]dithiane wherein the .sup.13 C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., [.sup.2 H.sub.1-2, .sup.13 C]methanol (arylthio)-, acetates wherein the .sup.13 C atom is directly bonded to exactly one or two deuterium atoms.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Wed Jan 01 00:00:00 EST 2003},

  month        = {Wed Jan 01 00:00:00 EST 2003}

}

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Works referenced in this record:

Stereoelectronic effects in the gas-phase. 2. Negative ion reactions of 1,3-dithianes and 1,3-dithiane 1-oxides
journal, September 1989

Fisher, Cindy L.; Kahn, Scott D.; Hehre, Warren J.
Journal of the American Chemical Society, Vol. 111, Issue 19
https://doi.org/10.1021/ja00201a015

The use of metalloids (-SiMe3,-SnR3) as protected carbanions
journal, January 1981

Andersen, Niels H.; McCrae, David A.; Grotjahn, Douglas B.
Tetrahedron, Vol. 37, Issue 23
https://doi.org/10.1016/S0040-4020(01)93282-X

9-Phenylfluorene: a powerful labeling agent
journal, July 2001

Cintrat, Jean-Christophe; Pillon, Florence; Rousseau, Bernard
Tetrahedron Letters, Vol. 42, Issue 30
https://doi.org/10.1016/S0040-4039(01)00903-0

Protonic and conformational equilibriums of 1,3-dithiaalkanes and their congeners in highly acidic media
journal, December 1979

Lambert, Joseph B.; Majchrzak, Michal W.; Stec, Daniel
The Journal of Organic Chemistry, Vol. 44, Issue 25
https://doi.org/10.1021/jo00393a046

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Similar Records

Title: Synthesis of 2H- and 13C-substituted dithanes

Abstract

Citation Formats

Stereoelectronic effects in the gas-phase. 2. Negative ion reactions of 1,3-dithianes and 1,3-dithiane 1-oxides journal, September 1989

The use of metalloids (-SiMe3,-SnR3) as protected carbanions journal, January 1981

9-Phenylfluorene: a powerful labeling agent journal, July 2001

Protonic and conformational equilibriums of 1,3-dithiaalkanes and their congeners in highly acidic media journal, December 1979

Stereoelectronic effects in the gas-phase. 2. Negative ion reactions of 1,3-dithianes and 1,3-dithiane 1-oxides
journal, September 1989

The use of metalloids (-SiMe3,-SnR3) as protected carbanions
journal, January 1981

9-Phenylfluorene: a powerful labeling agent
journal, July 2001

Protonic and conformational equilibriums of 1,3-dithiaalkanes and their congeners in highly acidic media
journal, December 1979