Synthesis Of [2h, 13c] And [2h3, 13c]Methyl Aryl Sulfides
Abstract
The present invention is directed to labeled compounds, [.sup.2 H.sub.1, .sup.13 C], [.sup.2 H.sub.2, .sup.13 C] and [.sup.2 H.sub.3, .sup.13 C]methyl aryl sulfides wherein the .sup.13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently, hydrogen, a C.sub.1 -C.sub.4 lower alkyl, a halogen, an amino group from the group consisting of NH.sub.2, NHR and NRR' where R and R' are each a C.sub.1 -C.sub.4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [.sup.2 H.sub.1, .sup.13 C], [.sup.2 H.sub.2,.sup.13 C] and [.sup.2 H.sub.3, .sup.13 C]methyl aryl sulfides wherein the .sup.13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [.sup.2 H.sub.1, .sup.13 C]methyl iodide and [.sup.2 H.sub.2, .sup.13 C]methyl iodide.
- Inventors:
-
- Santa Fe, NM
- (Los Alamos, NM)
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 879908
- Patent Number(s):
- 6713044
- Application Number:
- 10/342577
- Assignee:
- The Regents of the University of California (Los Alamos, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., and Unkefer, Clifford J. Synthesis Of [2h, 13c] And [2h3, 13c]Methyl Aryl Sulfides. United States: N. p., 2004.
Web.
Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., & Unkefer, Clifford J. Synthesis Of [2h, 13c] And [2h3, 13c]Methyl Aryl Sulfides. United States.
Martinez, Rodolfo A, Alvarez, Marc A, Silks, III, Louis A., and Unkefer, Clifford J. Tue .
"Synthesis Of [2h, 13c] And [2h3, 13c]Methyl Aryl Sulfides". United States. https://www.osti.gov/servlets/purl/879908.
@article{osti_879908,
title = {Synthesis Of [2h, 13c] And [2h3, 13c]Methyl Aryl Sulfides},
author = {Martinez, Rodolfo A and Alvarez, Marc A and Silks, III, Louis A. and Unkefer, Clifford J},
abstractNote = {The present invention is directed to labeled compounds, [.sup.2 H.sub.1, .sup.13 C], [.sup.2 H.sub.2, .sup.13 C] and [.sup.2 H.sub.3, .sup.13 C]methyl aryl sulfides wherein the .sup.13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently, hydrogen, a C.sub.1 -C.sub.4 lower alkyl, a halogen, an amino group from the group consisting of NH.sub.2, NHR and NRR' where R and R' are each a C.sub.1 -C.sub.4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [.sup.2 H.sub.1, .sup.13 C], [.sup.2 H.sub.2,.sup.13 C] and [.sup.2 H.sub.3, .sup.13 C]methyl aryl sulfides wherein the .sup.13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [.sup.2 H.sub.1, .sup.13 C]methyl iodide and [.sup.2 H.sub.2, .sup.13 C]methyl iodide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 30 00:00:00 EST 2004},
month = {Tue Mar 30 00:00:00 EST 2004}
}
Works referenced in this record:
Large-Scale Preparation of [ 13 C]Methyl Phenyl Sulfide from [ 13 C]Methanol by a One-Step Process
journal, November 2002
- Martinez, Rodolfo A.; Alvarez, Marc A.; Velarde, Stephen P.
- Organic Process Research & Development, Vol. 6, Issue 6
Synthese und NMR-Spektren einiger 13 C-markierter Thio- und Seleno-äther, -acetale und -orthoester
journal, June 1984
- Gabriel, Josef; Seebach, Dieter
- Helvetica Chimica Acta, Vol. 67, Issue 4
A practical laboratory route to the synthesis of trideuteriomethyl-[13C] iodide
journal, January 2003
- Coumbarides, Gregory S.; Eames, Jason; Weerasooriya, Neluka
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 4