Sample injector for high pressure liquid chromatography
Abstract
Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.
- Inventors:
-
- Livermore, CA
- Castro Valley, CA
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 874001
- Patent Number(s):
- 6290909
- Assignee:
- Sandia Corporation (Livermore, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- sample; injector; pressure; liquid; chromatography; apparatus; method; driving; well-defined; volume; column; conventional; sampling; valve; replaced; composed; pair; components; connected; series; common; junction; containers; porous; dielectric; material; constructed; provide; electroosmotic; flow; appropriate; time; pulse; source; electrokinetic; pump; drives; portion; size; determined; dead; chromatographic; subsequent; separation; analysis; fabricated; substrate; microanalytical; applications; subsequent separation; electrokinetic pump; liquid chromatograph; dead volume; liquid chromatography; dielectric material; chromatographic column; pressure liquid; chromatography column; appropriate time; pressure source; pressure pulse; sample injector; components connected; analytical applications; /422/73/204/210/
Citation Formats
Paul, Phillip H, Arnold, Don W, and Neyer, David W. Sample injector for high pressure liquid chromatography. United States: N. p., 2001.
Web.
Paul, Phillip H, Arnold, Don W, & Neyer, David W. Sample injector for high pressure liquid chromatography. United States.
Paul, Phillip H, Arnold, Don W, and Neyer, David W. Mon .
"Sample injector for high pressure liquid chromatography". United States. https://www.osti.gov/servlets/purl/874001.
@article{osti_874001,
title = {Sample injector for high pressure liquid chromatography},
author = {Paul, Phillip H and Arnold, Don W and Neyer, David W},
abstractNote = {Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
The fabrication of micro-porous silica structures for micro-reactor technology
journal, January 1998
- Christensen, P. D.; Johnson, S. W. P.; McCreedy, T.
- Analytical Communications, Vol. 35, Issue 10