Kit for providing a technetium medical radioimaging agent
Abstract
The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.
- Inventors:
-
- Richland, WA
- Greybull, WY
- Issue Date:
- Research Org.:
- Battelle Memorial Institute, Columbus, OH (United States)
- OSTI Identifier:
- 873391
- Patent Number(s):
- 6150155
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- kit; providing; technetium; medical; radioimaging; agent; directed; microbial; reduction; compound; form; compounds; value; imaging; combined; mixture; non-growing; cells; contain; technetium-reducing; enzyme; stabilizing; electron; donor; saline; solution; anaerobic; conditions; substantially; free; inorganic; reducing; products; resulting; product; tc; oxidation; partially; controlled; discovered; microorganisms; shewanella; alga; strain; bry; putrifacians; cn-32; systems; mono; nuclear; polynuclear; reduced; species; depending; saline solution; resulting product; substantially free; reducing agent; anaerobic conditions; electron donor; stabilizing agent; microbial reduction; medical imaging; imaging agent; technetium compound; microbial cell; aerobic conditions; /435/424/430/
Citation Formats
Wildung, Raymond E, Garland, Thomas R, and Li, Shu-Mei W. Kit for providing a technetium medical radioimaging agent. United States: N. p., 2000.
Web.
Wildung, Raymond E, Garland, Thomas R, & Li, Shu-Mei W. Kit for providing a technetium medical radioimaging agent. United States.
Wildung, Raymond E, Garland, Thomas R, and Li, Shu-Mei W. Sat .
"Kit for providing a technetium medical radioimaging agent". United States. https://www.osti.gov/servlets/purl/873391.
@article{osti_873391,
title = {Kit for providing a technetium medical radioimaging agent},
author = {Wildung, Raymond E and Garland, Thomas R and Li, Shu-Mei W},
abstractNote = {The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}