Title: Methods and kits for predicting a response to an erythropoietic agent

Abstract

Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.

Inventors:

Merchant, Michael L.; Klein, Jon B.; Brier, Michael E.; Gaweda, Adam E.

Issue Date:

2015-06-16

Research Org.:

University of Louisville Research Foundation, Inc., Louisville, KY (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1184560

Patent Number(s):

9057731

Application Number:

13/167,478

Assignee:

University of Louisville Research Foundation, Inc. (Louisville, KY)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2333/47 - Assays involving proteins of known structure or function as defined in the subgroups
G01N2800/52 - Predicting or monitoring the response to treatment
G01N33/68 - involving proteins, peptides or amino acids {
G01N33/6863 - {Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors}
G01N33/6893 - {related to diseases not provided for elsewhere}

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DOE Contract Number:  

FG02-05ER64060

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES