No-carrier-added [1.sup.11 c]putrescine
Abstract
The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.
- Inventors:
-
- Baltimore, MD
- Bellport, NY
- Setauket, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 867138
- Patent Number(s):
- 4874600
- Assignee:
- United States of America as Represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- no-carrier-added; 11; putrescine; relates; radiolabeled; imaging; agent; 1-; pure; material; radiotracer; positron; emission; tomography; brain; tumors; synthesis; based; michael; addition; potassium; c-labeled; cyanide; acrylonitrile; followed; reduction; dinitrile; method; rapid; efficient; provides; specific; activity; curies; millimol; purity; 95; emission tomography; positron emission; specific activity; imaging agent; pure material; brain tumors; /424/999/
Citation Formats
McPherson, Daniel W, Fowler, Joanna S, and Wolf, Alfred P. No-carrier-added [1.sup.11 c]putrescine. United States: N. p., 1989.
Web.
McPherson, Daniel W, Fowler, Joanna S, & Wolf, Alfred P. No-carrier-added [1.sup.11 c]putrescine. United States.
McPherson, Daniel W, Fowler, Joanna S, and Wolf, Alfred P. Sun .
"No-carrier-added [1.sup.11 c]putrescine". United States. https://www.osti.gov/servlets/purl/867138.
@article{osti_867138,
title = {No-carrier-added [1.sup.11 c]putrescine},
author = {McPherson, Daniel W and Fowler, Joanna S and Wolf, Alfred P},
abstractNote = {The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}