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Title: Process and targets for production of no-carrier-added radiotin

Abstract

One embodiment of the present invention includes a process for production and recovery of no-carrier-added radioactive tin (NCA radiotin). An antimony target can be irradiated with a beam of accelerated particles forming NCA radiotin, followed by separation of the NCA radiotin from the irradiated target. The target is metallic Sb in a hermetically sealed shell. The shell can be graphite, molybdenum, or stainless steel. The irradiated target can be removed from the shell by chemical or mechanical means, and dissolved in an acidic solution. Sb can be removed from the dissolved irradiated target by extraction. NCA radiotin can be separated from the remaining Sb and other impurities using chromatography on silica gel sorbent. NCA tin-117m can be obtained from this process. NCA tin-117m can be used for labeling organic compounds and biological objects to be applied in medicine for imaging and therapy of various diseases.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1129379
Patent Number(s):
8,705,681
Application Number:
11/962,851
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Dec 21
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS

Citation Formats

Srivastava, Suresh C, Zhuikov, Boris Leonidovich, Ermolaev, Stanislav Victorovich, Konyakhin, Nikolay Alexandrovich, Kokhanyuk, Vladimir Mikhailovich, Khamyanov, Stepan Vladimirovich, and Togaeva, Natalya Roaldovna. Process and targets for production of no-carrier-added radiotin. United States: N. p., 2014. Web.
Srivastava, Suresh C, Zhuikov, Boris Leonidovich, Ermolaev, Stanislav Victorovich, Konyakhin, Nikolay Alexandrovich, Kokhanyuk, Vladimir Mikhailovich, Khamyanov, Stepan Vladimirovich, & Togaeva, Natalya Roaldovna. Process and targets for production of no-carrier-added radiotin. United States.
Srivastava, Suresh C, Zhuikov, Boris Leonidovich, Ermolaev, Stanislav Victorovich, Konyakhin, Nikolay Alexandrovich, Kokhanyuk, Vladimir Mikhailovich, Khamyanov, Stepan Vladimirovich, and Togaeva, Natalya Roaldovna. Tue . "Process and targets for production of no-carrier-added radiotin". United States. https://www.osti.gov/servlets/purl/1129379.
@article{osti_1129379,
title = {Process and targets for production of no-carrier-added radiotin},
author = {Srivastava, Suresh C and Zhuikov, Boris Leonidovich and Ermolaev, Stanislav Victorovich and Konyakhin, Nikolay Alexandrovich and Kokhanyuk, Vladimir Mikhailovich and Khamyanov, Stepan Vladimirovich and Togaeva, Natalya Roaldovna},
abstractNote = {One embodiment of the present invention includes a process for production and recovery of no-carrier-added radioactive tin (NCA radiotin). An antimony target can be irradiated with a beam of accelerated particles forming NCA radiotin, followed by separation of the NCA radiotin from the irradiated target. The target is metallic Sb in a hermetically sealed shell. The shell can be graphite, molybdenum, or stainless steel. The irradiated target can be removed from the shell by chemical or mechanical means, and dissolved in an acidic solution. Sb can be removed from the dissolved irradiated target by extraction. NCA radiotin can be separated from the remaining Sb and other impurities using chromatography on silica gel sorbent. NCA tin-117m can be obtained from this process. NCA tin-117m can be used for labeling organic compounds and biological objects to be applied in medicine for imaging and therapy of various diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {4}
}

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Works referenced in this record:

Production of carrier-free 117mSn
journal, July 1984

  • Qaim, S. M.; Döhler, H.
  • The International Journal of Applied Radiation and Isotopes, Vol. 35, Issue 7, p. 645-650
  • DOI: 10.1016/0020-708X(84)90110-8

Nuclear data for production of 117m Sn for biomedical application
journal, March 1986


Improved specific activity of reactor produced 117mSn with the Szilard-Chalmers process
journal, September 1992

  • Mausner, L. F.; Mirzadeh, S.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 9, p. 1117-1122
  • DOI: 10.1016/0883-2889(92)90053-H

Production yields of117mSn from natural antimony target in proton energy range 145–35 MeV
journal, January 2007

  • Ermolaev, Stanislav V.; Zhuikov, Boris L.; Kokhanyuk, Vladimir M.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 50, Issue 5-6
  • DOI: 10.1002/jlcr.1307