1-.sup.11 C-D-Glucose and related compounds

Shiue, Chyng-Yann; Wolf, Alfred P

Title: 1-.sup.11 C-D-Glucose and related compounds

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Abstract

The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.

Inventors:

Shiue, Chyng-Yann ^[1]; Wolf, Alfred P ^[2]

Wading River, NY
Setauket, NY

Issue Date:: 1984-03-27

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 864932

Patent Number(s):: 4439414

Application Number:: 06/342,684

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo

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DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 1-; 11; c-d-glucose; related; compounds; novel; c-d-mannose; c-d-galactose; 2-; nuclear; medicine; monitor; metabolism; glucose; galactose; rapidly; prepared; reaction; appropriate; aldose; substrate; alkali; metal; c-labeled; cyanide; followed; reduction; raney; alloy; formic; acid; related compounds; nuclear medicine; alkali metal; novel compounds; formic acid; novel compound; /424/127/250/999/600/

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                    Shiue, Chyng-Yann, and Wolf, Alfred P. 1-.sup.11 C-D-Glucose and related compounds.  United States: N. p., 1984. 
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                    Shiue, Chyng-Yann, & Wolf, Alfred P. 1-.sup.11 C-D-Glucose and related compounds.  United States.

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                    Shiue, Chyng-Yann, and Wolf, Alfred P. Tue .  
        "1-.sup.11 C-D-Glucose and related compounds".  United States.  https://www.osti.gov/servlets/purl/864932.

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@article{osti_864932,

  title        = {1-.sup.11 C-D-Glucose and related compounds},

  author       = {Shiue, Chyng-Yann and Wolf, Alfred P},

  abstractNote = {The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1984},

  month        = {3}

}

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