Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy

Demos, Stavros G.

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Title: Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy

Abstract

A method is described to enhance the ability to evaluate the depth of a tissue component or a lesion having optical properties different from a surrounding tissue using time resolved optical methods. This invention may be particularly suitable for the evaluation of lesion depth during RF ablation (irreversible tissue modification/damage) using specially designed devises (catheters) that deliver heat in a localized region for therapeutic reasons. The technique allows for increased ability to evaluate the depth of the ablated lesion or detect the presence of other processes such as micro-bubble formation and coagulation with higher sensitivity compared to that offered by steady state spectroscopy. The method can be used for in-vivo, real-time monitoring during tissue ablation or other procedures where information on the depth of a lesion or tissue is needed. Exemplary uses are found in tissue ablation, tissue thermal damage, lesion and tissue depth assessment in medical applications.

Inventors:: Demos, Stavros G.

Issue Date:: Tue Sep 17 00:00:00 EDT 2019

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1576298

Patent Number(s):: 10413188

Application Number:: 13/796,880

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B18/082 - {Probes or electrodes therefor}
A61B18/1492 - {having a flexible, catheter-like structure, e.g. for heart ablation
A61B18/22 - the beam being directed along or through a flexible conduit, e.g. an optical fibre
A61B18/24 - with a catheter
A61B2017/00061 - {spectrum}
A61B2017/00066 - {intensity}
A61B2018/00351 - {Heart}
A61B2018/00357 - {Endocardium}
A61B2018/0212 - {using an instrument inserted into a body lumen, e.g. catheter}
A61B2090/062 - {penetration depth}
A61B5/0075 - {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B5/0084 - {for introduction into the body, e.g. by catheters
A61B5/0086 - {using infra-red radiation}

Show less

DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Mar 12

Country of Publication:: United States

Language:: English

Subject:: 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Demos, Stavros G. Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy.  United States: N. p., 2019. 
        Web.

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                    Demos, Stavros G. Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy.  United States.

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                    Demos, Stavros G. Tue .  
        "Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy".  United States.  https://www.osti.gov/servlets/purl/1576298.

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@article{osti_1576298,

  title        = {Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy},

  author       = {Demos, Stavros G.},

  abstractNote = {A method is described to enhance the ability to evaluate the depth of a tissue component or a lesion having optical properties different from a surrounding tissue using time resolved optical methods. This invention may be particularly suitable for the evaluation of lesion depth during RF ablation (irreversible tissue modification/damage) using specially designed devises (catheters) that deliver heat in a localized region for therapeutic reasons. The technique allows for increased ability to evaluate the depth of the ablated lesion or detect the presence of other processes such as micro-bubble formation and coagulation with higher sensitivity compared to that offered by steady state spectroscopy. The method can be used for in-vivo, real-time monitoring during tissue ablation or other procedures where information on the depth of a lesion or tissue is needed. Exemplary uses are found in tissue ablation, tissue thermal damage, lesion and tissue depth assessment in medical applications.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Sep 17 00:00:00 EDT 2019},

  month        = {Tue Sep 17 00:00:00 EDT 2019}

}

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Title: Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy

Abstract

Citation Formats

Phototherapeutic Wave Guide Apparatus patent-application, December 2002

Apparatus for Real Time Evaluation of Tissue Ablation patent-application, June 2006

Apparatus for Ablating Turbinates patent-application, July 2002

Optical Switching System for Catheter-Based Analysis and Treatment patent-application, August 2005

Irrigated ablation device assembly patent, February 2003

Minimally invasive apparatus for internal ablation of turbinates patent, October 1998

Photodynamic-Based Tissue Sensing Device and Method patent-application, November 2010

Method for laser induced fluorescence of tissue patent, May 1995

Apparatus for tissue type recognition patent, September 1998

Optical biopsy system and methods for tissue diagnosis patent, January 2001

Catheter with multi port tip for optical lesion evaluation patent, February 2010

Tissue Biopsy and Treatment Apparatus and Method patent-application, February 2002

Dynamic heating method and radio frequency thermal treatment patent, January 2000

Endoscopic Ablation System with a Distally Mounted Image Sensor patent-application, September 2003

Endothelium preserving microwave treatment for atherosclerosis patent, April 2000

Catheter for laser angiosurgery patent, April 1990

Catheter with Multi Port Tip for Optical Lesion Evaluation patent-application, December 2007

Method for the ablation treatment of the uvula patent, May 1996

Device and method for analysis of surgical tissue interventions patent, June 1998

Laser fusion of biological materials patent, December 1991

Tissue Ablation Apparatus and Method patent-application, November 2003

Fiber Optic Evaluation of Tissue Modification patent-application, October 2006

Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation patent, July 2011

Catheter with Omni-Directional Optical Lesion Evaluation patent-application, January 2009

Spectral diagonostic and treatment system patent, April 1994

Devices and methods for optical diagnosis of tissue patent, January 1994

Catheters for imaging, sensing electrical potentials, and ablating tissue patent, December 1999

Tissue ablation apparatus and method patent, January 2007

Deflectable catheter with rotatable tip electrode patent, September 1993

Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy patent, August 1997

Endoscope for Observing Scattered Light from Living Body Tissue and Method of Observing Scattered Light from Living Body Tissue patent-application, March 2005

Phototherapeutic Wave Guide Apparatus
patent-application, December 2002

Apparatus for Real Time Evaluation of Tissue Ablation
patent-application, June 2006

Apparatus for Ablating Turbinates
patent-application, July 2002

Optical Switching System for Catheter-Based Analysis and Treatment
patent-application, August 2005

Irrigated ablation device assembly
patent, February 2003

Minimally invasive apparatus for internal ablation of turbinates
patent, October 1998

Photodynamic-Based Tissue Sensing Device and Method
patent-application, November 2010

Method for laser induced fluorescence of tissue
patent, May 1995

Apparatus for tissue type recognition
patent, September 1998

Optical biopsy system and methods for tissue diagnosis
patent, January 2001

Catheter with multi port tip for optical lesion evaluation
patent, February 2010

Tissue Biopsy and Treatment Apparatus and Method
patent-application, February 2002

Dynamic heating method and radio frequency thermal treatment
patent, January 2000

Endoscopic Ablation System with a Distally Mounted Image Sensor
patent-application, September 2003

Endothelium preserving microwave treatment for atherosclerosis
patent, April 2000

Catheter for laser angiosurgery
patent, April 1990

Catheter with Multi Port Tip for Optical Lesion Evaluation
patent-application, December 2007

Method for the ablation treatment of the uvula
patent, May 1996

Device and method for analysis of surgical tissue interventions
patent, June 1998

Laser fusion of biological materials
patent, December 1991

Tissue Ablation Apparatus and Method
patent-application, November 2003

Fiber Optic Evaluation of Tissue Modification
patent-application, October 2006

Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation
patent, July 2011

Catheter with Omni-Directional Optical Lesion Evaluation
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Spectral diagonostic and treatment system
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Devices and methods for optical diagnosis of tissue
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Catheters for imaging, sensing electrical potentials, and ablating tissue
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Tissue ablation apparatus and method
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Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy
patent, August 1997

Endoscope for Observing Scattered Light from Living Body Tissue and Method of Observing Scattered Light from Living Body Tissue
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