Biosensor method and system based on feature vector extraction

Greenbaum, Elias; Rodriguez, Miguel; Qi, Hairong; Wang, Xiaoling

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Title: Biosensor method and system based on feature vector extraction

Abstract

A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.

Inventors:: Greenbaum, Elias; Rodriguez, Jr., Miguel; Qi, Hairong; Wang, Xiaoling

Issue Date:: Tue Jul 02 00:00:00 EDT 2013

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1086740

Patent Number(s):: 8476062

Application Number:: 13/431,664

Assignee:: University of Tennessee Research Foundation (Knoxville, TN); UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/025 - {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

Show less

DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Greenbaum, Elias, Rodriguez, Jr., Miguel, Qi, Hairong, and Wang, Xiaoling. Biosensor method and system based on feature vector extraction.  United States: N. p., 2013. 
        Web.

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                    Greenbaum, Elias, Rodriguez, Jr., Miguel, Qi, Hairong, & Wang, Xiaoling. Biosensor method and system based on feature vector extraction.  United States.

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                    Greenbaum, Elias, Rodriguez, Jr., Miguel, Qi, Hairong, and Wang, Xiaoling. Tue .  
        "Biosensor method and system based on feature vector extraction".  United States.  https://www.osti.gov/servlets/purl/1086740.

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@article{osti_1086740,

  title        = {Biosensor method and system based on feature vector extraction},

  author       = {Greenbaum, Elias and Rodriguez, Jr., Miguel and Qi, Hairong and Wang, Xiaoling},

  abstractNote = {A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 02 00:00:00 EDT 2013},

  month        = {Tue Jul 02 00:00:00 EDT 2013}

}

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Similar Records

Title: Biosensor method and system based on feature vector extraction

Abstract

Citation Formats

Development and evaluation of electrochemical glucose enzyme biosensors based on carbon film electrodes journal, January 2005

Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control patent, April 2000

Measurement chip for surface plasmon resonance biosensor patent, April 2004

Water monitoring systems patent, September 2006

Methods, systems, and software for identifying functional biomolecules patent, June 2010

Biosensors for rapid monitoring of primary-source drinking water using naturally occurring photosynthesis journal, October 2002

Method and apparatus for enhanced detection of toxic agents patent, June 2012

Velocity modulated capillary electrophoresis analysis system patent, March 1990

Acoustic biosensor for monitoring physiological conditions in a body implantation site patent, November 2002

Ultrasensitive magnetic biosensor for homogeneous immunoassay journal, December 2000

Fast repetition rate (FRR) fluorometer and method for measuring fluorescence and photosynthetic parameters patent, June 1995

Fluorometric detection using visible light patent, March 2001

Bacterial spore detection and quantification methods patent, March 1999

Aqueous fluid purification monitoring and control system and process patent, July 1998

Long-Range AC Electroosmotic Trapping and Detection of Bioparticles journal, April 2005

Biosensor patent, February 2004

Tissue-based water quality biosensors for detecting chemical warfare agents patent, May 2003

Separation of a Liquid Containing Charged Particles or/and Polarizable Molecules patent, February 1974

Rolled electroactive polymers patent, May 2005

Electrochemical sensor patent, September 1997

Fast repetition rate (FRR) flasher patent, February 1997

Composite beads comprising magnetizable substance and electro-conductive substance patent, May 2007

An AC Electrokinetic Technique for Collection and Concentration of Particles and Cells on Patterned Electrodes journal, July 2005

Portable lead detector patent, August 1995

Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy patent, June 2003

Signal detection techniques for the detection of analytes patent, May 2004

Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures patent, March 2006

Acoustic immunosensor for real-time sensing of neurotransmitter GABA conference, January 2003

Method and apparatus for detection of sand formations in amplitude-versus-offset seismic surveys patent, August 1997

Automated analyzing apparatus for measuring water quality with a cylinder-shaped syringe unit patent, October 1998

Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate patent, August 2004

Measuring indigenous photosynthetic organisms to detect chemical warefare agents in water patent, November 2005

Optical biosensor system patent, May 1994

Microfluidic pumps and mixers driven by induced-charge electro-osmosis patent, July 2006

Development of infrared optical sensor for selective detection of tyrosine in biological fluids journal, September 2005

Particle detection by electrical impedance spectroscopy with asymmetric-polarization AC electroosmotic trapping journal, April 2005

Controlled natural purification system for advanced wastewater treatment and protein conversion and recovery patent, May 1981

Submicron and nano size particle encapsulation by electrochemical process and apparatus patent, September 2005

Magnetic resonance as a technique to magnetic biosensors characterization in Neocapritermes opacus termites journal, July 2005

Regenerable biosensor using total internal reflection fluorescence with electrochemical control patent, January 2003

Stand-off tissue-based biosensors for the detection of chemical warfare agents using photosynthetic fluorescence induction journal, September 2001

Development and evaluation of electrochemical glucose enzyme biosensors based on carbon film electrodes
journal, January 2005

Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control
patent, April 2000

Measurement chip for surface plasmon resonance biosensor
patent, April 2004

Water monitoring systems
patent, September 2006

Methods, systems, and software for identifying functional biomolecules
patent, June 2010

Biosensors for rapid monitoring of primary-source drinking water using naturally occurring photosynthesis
journal, October 2002

Method and apparatus for enhanced detection of toxic agents
patent, June 2012

Velocity modulated capillary electrophoresis analysis system
patent, March 1990

Acoustic biosensor for monitoring physiological conditions in a body implantation site
patent, November 2002

Ultrasensitive magnetic biosensor for homogeneous immunoassay
journal, December 2000

Fast repetition rate (FRR) fluorometer and method for measuring fluorescence and photosynthetic parameters
patent, June 1995

Fluorometric detection using visible light
patent, March 2001

Bacterial spore detection and quantification methods
patent, March 1999

Aqueous fluid purification monitoring and control system and process
patent, July 1998

Long-Range AC Electroosmotic Trapping and Detection of Bioparticles
journal, April 2005

Biosensor
patent, February 2004

Tissue-based water quality biosensors for detecting chemical warfare agents
patent, May 2003

Separation of a Liquid Containing Charged Particles or/and Polarizable Molecules
patent, February 1974

Rolled electroactive polymers
patent, May 2005

Electrochemical sensor
patent, September 1997

Fast repetition rate (FRR) flasher
patent, February 1997

Composite beads comprising magnetizable substance and electro-conductive substance
patent, May 2007

An AC Electrokinetic Technique for Collection and Concentration of Particles and Cells on Patterned Electrodes
journal, July 2005

Portable lead detector
patent, August 1995

Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy
patent, June 2003

Signal detection techniques for the detection of analytes
patent, May 2004

Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures
patent, March 2006

Acoustic immunosensor for real-time sensing of neurotransmitter GABA
conference, January 2003

Method and apparatus for detection of sand formations in amplitude-versus-offset seismic surveys
patent, August 1997

Automated analyzing apparatus for measuring water quality with a cylinder-shaped syringe unit
patent, October 1998

Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
patent, August 2004

Measuring indigenous photosynthetic organisms to detect chemical warefare agents in water
patent, November 2005

Optical biosensor system
patent, May 1994

Microfluidic pumps and mixers driven by induced-charge electro-osmosis
patent, July 2006

Development of infrared optical sensor for selective detection of tyrosine in biological fluids
journal, September 2005

Particle detection by electrical impedance spectroscopy with asymmetric-polarization AC electroosmotic trapping
journal, April 2005

Controlled natural purification system for advanced wastewater treatment and protein conversion and recovery
patent, May 1981

Submicron and nano size particle encapsulation by electrochemical process and apparatus
patent, September 2005

Magnetic resonance as a technique to magnetic biosensors characterization in Neocapritermes opacus termites
journal, July 2005

Regenerable biosensor using total internal reflection fluorescence with electrochemical control
patent, January 2003

Stand-off tissue-based biosensors for the detection of chemical warfare agents using photosynthetic fluorescence induction
journal, September 2001