Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer
Abstract
Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.
- Inventors:
-
- El Cerrito, CA
- San Ramon, CA
- San Mateo, CA
- San Francisco, CA
- Issue Date:
- Research Org.:
- University of California (Oakland, CA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1055690
- Patent Number(s):
- 8198254
- Application Number:
- 12/412,304
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, and Gray, Joe W. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer. United States: N. p., 2012.
Web.
Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, & Gray, Joe W. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer. United States.
Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, and Gray, Joe W. Tue .
"Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer". United States. https://www.osti.gov/servlets/purl/1055690.
@article{osti_1055690,
title = {Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer},
author = {Hu, Zhi and Kuo, Wen-Lin and Neve, Richard M and Gray, Joe W},
abstractNote = {Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 12 00:00:00 EDT 2012},
month = {Tue Jun 12 00:00:00 EDT 2012}
}
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