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Title: Identification of cancer protein biomarkers using proteomic techniques

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1329309
Assignee:
Yale University (New Haven, CT CHO
Patent Number(s):
9,470,688
Application Number:
14/602,916
Contract Number:
FG02-ER63462
Resource Relation:
Patent File Date: 2015 Jul 22
Research Org:
Yale Univ., New Haven, CT (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Use of serum prolactin for monitoring the therapeutic response in ovarian malignancy
journal, September 1991
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  • International Journal of Gynecology & Obstetrics, Vol. 36, Issue 1, p. 33-38
  • DOI: 10.1016/0020-7292(91)90175-5

Circulating levels of insulin-like growth factor-II and IGF-binding protein 3 in cervical cancer
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Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma
journal, October 2004

Serum protein markers for early detection of ovarian cancer
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Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-α in mammary cells: a role in differentiated secretory epithelium
journal, September 2004

Serum tumor markers in colorectal cancer staging, grading, and follow-up
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journal, April 2002
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  • DOI: 10.1038/nbt0402-359

Cancer screening in a high risk population: a clinical trial
journal, April 2001

The role of Osteopontin in tumor metastasis
journal, October 2004

Differential Gene Expression in Chemically Induced Mouse Lung Adenomas
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Ovarian dysgerminoma showing high serum levels and positive immunostaining of placental alkaline phosphatase and neuron-specific enolase associated with elevation of serum prolactin level
journal, October 1998
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  • DOI: 10.1016/S0301-2115(98)00162-6

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