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Title: Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids

Abstract

Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.

Inventors:
 [1];  [2];  [3]
  1. (Setauket, NY)
  2. (Upton, NY)
  3. (Middle Island, NY)
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY
OSTI Identifier:
875137
Patent Number(s):
6541514
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
process; manufacture; 117sn; diethylenetriaminepentaacetic; acids; novel; methods; provided; sup117m; snsnsup4; dtpa; method; allows; toxic; chelating; agent; approximately; 11; ratio; via; aqueous; conditions; organic; solvents; methylene; chloride; pharmaceutical; composition; manufactured; treatment; bone; tumors; pain; associated; cancer; organic solvent; chelating agent; acetic acid; /514/424/999/600/

Citation Formats

Srivastava, Suresh C., Li, Zizhong, and Meinken, George. Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids. United States: N. p., 2003. Web.
Srivastava, Suresh C., Li, Zizhong, & Meinken, George. Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids. United States.
Srivastava, Suresh C., Li, Zizhong, and Meinken, George. Wed . "Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids". United States. https://www.osti.gov/servlets/purl/875137.
@article{osti_875137,
title = {Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids},
author = {Srivastava, Suresh C. and Li, Zizhong and Meinken, George},
abstractNote = {Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

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