Human jagged polypeptide, encoding nucleic acids and methods of use
Abstract
The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
- Inventors:
-
- Seattle, WA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 873333
- Patent Number(s):
- 6136952
- Assignee:
- University of Washington (Seattle, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- human; jagged; polypeptide; encoding; nucleic; acids; methods; provides; isolated; exhibiting; substantially; amino; acid; sequence; active; fragment; provided; seq; molecule; containing; nucleotide; encode; method; inhibiting; differentiation; hematopoietic; progenitor; cells; contacting; additionally; diagnosing; alagille; syndrome; individual; consists; detecting; disease-associated; mutation; linked; locus; acid molecule; method consists; molecule containing; nucleotide sequence; acid sequence; amino acid; nucleic acid; nucleic acids; sequence encoding; isolated polypeptide; /530/435/999/
Citation Formats
Li, Linheng, and Hood, Leroy. Human jagged polypeptide, encoding nucleic acids and methods of use. United States: N. p., 2000.
Web.
Li, Linheng, & Hood, Leroy. Human jagged polypeptide, encoding nucleic acids and methods of use. United States.
Li, Linheng, and Hood, Leroy. Sat .
"Human jagged polypeptide, encoding nucleic acids and methods of use". United States. https://www.osti.gov/servlets/purl/873333.
@article{osti_873333,
title = {Human jagged polypeptide, encoding nucleic acids and methods of use},
author = {Li, Linheng and Hood, Leroy},
abstractNote = {The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}
Works referenced in this record:
Molecular and cytogenetic analysis of an interstitial 20p deletion associated with syndromic intrahepatic ductular hypoplasia (Alagille syndrome)
journal, October 1989
- Schnittger, Susanne; H�fers, Christiane; Heidemann, Peter
- Human Genetics, Vol. 83, Issue 3
Construction of a 3.7-Mb Physical Map within Human Chromosome 20p12 Ordering 18 Markers in the Alagille Syndrome Locus
journal, June 1995
- Pollet, Nicolas; Dhorne-Pollet, Sophie; Deleuze, Jean-François
- Genomics, Vol. 27, Issue 3
An Antisense Oligonucleotide to the Notch Ligand Jagged Enhances Fibroblast Growth Factor-induced Angiogenesis in Vitro
journal, December 1996
- Zimrin, Ann B.; Pepper, Michael S.; McMahon, Grainne A.
- Journal of Biological Chemistry, Vol. 271, Issue 51
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous
journal, December 1990
- Baker, N.; Mlodzik, M.; Rubin, G.
- Science, Vol. 250, Issue 4986
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages
journal, November 1996
- Robey, Ellen; Chang, David; Itano, Andrea
- Cell, Vol. 87, Issue 3
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
journal, August 1991
- Ellisen, Leif W.; Bird, Jeffrey; West, Daniel C.
- Cell, Vol. 66, Issue 4
Notch is required for wingless signaling in the epidermis of Drosophila
journal, October 1994
- Couso, J.
- Cell, Vol. 79, Issue 2
The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1
journal, January 1998
- Li, Linheng; Milner, Laurie A.; Deng, Yu
- Immunity, Vol. 8, Issue 1
Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis
journal, November 1996
- Shawber, Carrie; Boulter, Jim; Lindsell, Claire E.
- Developmental Biology, Vol. 180, Issue 1
A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
journal, April 1994
- Milner, La; Kopan, R.; Martin, Di
- Blood, Vol. 83, Issue 8
Mutations in the human Jagged1 gene are responsible for Alagille syndrome
journal, July 1997
- Oda, Takaya; Elkahloun, Abdel G.; Pike, Brian L.
- Nature Genetics, Vol. 16, Issue 3
A role for the Drosophila neurogenic genes in mesoderm differentiation
journal, October 1991
- Corbin, Victoria; Michelson, Alan M.; Abmayr, Susan M.
- Cell, Vol. 67, Issue 2
Jagged: A mammalian ligand that activates notch1
journal, March 1995
- Lindsell, Claire E.; Shawber, Carrie J.; Boulter, Jim
- Cell, Vol. 80, Issue 6
Inhibition of granulocytic differentiation by mNotch1
journal, November 1996
- Milner, L. A.; Bigas, A.; Kopan, R.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 23
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
journal, July 1997
- Li, Linheng; Krantz, Ian D.; Deng, Yu
- Nature Genetics, Vol. 16, Issue 3
Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes
journal, February 1995
- Roecklein, Ba; Torok-Storb, B.
- Blood, Vol. 85, Issue 4
Identification and Cloning of the Human Homolog (JAG1) of the RatJagged1Gene from the Alagille Syndrome Critical Region at 20p12
journal, August 1997
- Oda, Takaya; Elkahloun, Abdel G.; Meltzer, Paul S.
- Genomics, Vol. 43, Issue 3
Mapping of Microsatellite Markers
in the Alagille Region and
Screening of Microdeletions by
Genotyping 23 Patients
journal, January 1994
- Deleuze, Jean-François; Hazan, Jamilé; Dhorne, Sophie
- European Journal of Human Genetics, Vol. 2, Issue 3
Alagille syndrome.
journal, February 1997
- Krantz, I. D.; Piccoli, D. A.; Spinner, N. B.
- Journal of Medical Genetics, Vol. 34, Issue 2
Hematopoietic cell culture therapies (Part I): cell culture considerations
journal, September 1996
- McAdams, Todd A.; Miller, William M.; Terry Papoutsakis, E.
- Trends in Biotechnology, Vol. 14, Issue 9
Developmental Signalling: Vertebrate ligands for Notch
journal, September 1995
- Nye, Jeffrey S.; Kopan, Raphael
- Current Biology, Vol. 5, Issue 9
Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila
journal, March 1994
- Tax, Frans E.; Yeargers, Jon J.; Thomas, James H.
- Nature, Vol. 368, Issue 6467