Title: Polymeric assemblies for sensitive colorimetric assays

Abstract

The presently claimed invention relates to polymeric assemblies which visibly change color in the presence of analyte. In particular, the presently claimed invention relates to liposomes comprising a plurality of lipid monomers, which comprises a polymerizable group, a hydrophilic head group and a hydrophobic tail group, and one or more ligands. Overall carbon chain length, and polymerizable group positioning on the monomer influence color change sensitivity to analyte concentrations.

Inventors:

Charych, Deborah ^[1]

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1. Albany, CA

Issue Date:

Sat Jan 01 00:00:00 EST 2000

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

873157

Patent Number(s):

6103217

Assignee:

Regents of University of California (CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K9/1273 - {Polymersomes

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/586 - {Liposomes, microcapsules or cells}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Y02A50/30 - Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T428/31645 - Next to addition polymer from unsaturated monomers
Y10T428/31696 - Including polyene monomers [e.g., butadiene, etc.]

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

polymeric; assemblies; sensitive; colorimetric; assays; presently; claimed; relates; visibly; change; color; presence; analyte; particular; liposomes; comprising; plurality; lipid; monomers; comprises; polymerizable; hydrophilic; head; hydrophobic; tail; ligands; overall; carbon; chain; length; positioning; monomer; influence; sensitivity; concentrations; color change; chain length; colorimetric assays; colorimetric assay; polymeric assemblies; change color; presently claimed; carbon chain; /424/422/428/436/