Title: Polymeric assay film for direct colorimetric detection

Abstract

A lipid bilayer with affinity to an analyte, which directly signals binding by a changes in the light absorption spectra. This novel assay means and method has special applications in the drug development and medical testing fields. Using a spectrometer, the system is easily automated, and a multiple well embodiment allows inexpensive screening and sequential testing. This invention also has applications in industry for feedstock and effluent monitoring.

Inventors:

Charych, Deborah ^[1]; Nagy, Jon ^[2]; Spevak, Wayne ^[1]

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+ Show Inventor Affiliations

1. Albany, CA
2. Rodeo, CA

Issue Date:

1999-01-01

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

872752

Patent Number(s):

6001556

Assignee:

Regents of University of California (CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/54373 - {involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T428/31645 - Next to addition polymer from unsaturated monomers
Y10T428/31649 - Ester, halide or nitrile of addition polymer

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

polymeric; assay; film; direct; colorimetric; detection; lipid; bilayer; affinity; analyte; directly; signals; binding; changes; light; absorption; spectra; novel; means; method; special; applications; drug; medical; testing; fields; spectrometer; easily; automated; multiple; embodiment; allows; inexpensive; screening; sequential; industry; feedstock; effluent; monitoring; absorption spectra; light absorption; special applications; special application; colorimetric detection; direct colorimetric; /435/422/427/428/436/