Title: Three-dimensional colorimetric assay assemblies

Abstract

A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flue virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

Inventors:

Charych, Deborah ^[1]; Reichert, Anke ^[1]

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1. Albany, CA

Issue Date:

Mon Jan 01 00:00:00 EST 2001

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

873523

Patent Number(s):

6180135

Application Number:

08/944,323

Assignee:

The Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2333/11 - Orthomyxoviridae, e.g. influenza virus
G01N2333/924 - acting on glycosyl compounds
G01N33/5432 - {Liposomes or microcapsules}
G01N33/586 - {Liposomes, microcapsules or cells}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Y02A50/30 - Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S424/812 - Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
Y10S436/805 - Optical property
Y10S436/829 - Liposomes, e.g. encapsulation
Y10S977/80 - Nucleic acid, e.g. DNA or RNA
Y10S977/801 - Drug
Y10S977/897 - Polymerization
Y10S977/898 - Enzymatic
Y10S977/907 - Liposome
Y10S977/92 - Detection of biochemical
Y10S977/927 - Diagnostic contrast agent

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Resource Relation:

Patent File Date: 1997 Oct 06

Country of Publication:

United States

Language:

English

Subject:

three-dimensional; colorimetric; assay; assemblies; direct; described; novel; polymeric; change; blue; color; exposed; analyte; flue; virus; typically; form; liposomes; maintained; suspension; intensity; changes; method; production; color change; color changes; colorimetric assay; polymeric assemblies; novel three-dimensional; three-dimensional polymeric; assay assemblies; direct assay; /424/436/