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Title: Immobilized lipid-bilayer materials

Abstract

A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.

Inventors:
 [1];  [1];  [2]
  1. (Albuquerque, NM)
  2. (Dallas, TX)
Issue Date:
Research Org.:
SANDIA CORP
OSTI Identifier:
872946
Patent Number(s):
6048546
Assignee:
Sandia Corporation (Albuquerque, NM) SNL
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
immobilized; lipid-bilayer; materials; method; preparing; encapsulated; silica; matrix; comprising; sol; mixing; material; allowing; mixture; form; mild; processing; conditions; allow; quantitative; entrapment; pre-formed; modification; spectral; characteristics; allows; immobilization; lipid; membranes; surfaces; perform; sensitive; optical; sensors; detection; analytes; heavy; metal; drug; delivery; systems; separation; devices; comprising preparing; silica sol; optical sensors; heavy metal; drug delivery; optical sensor; method allows; separation devices; matrix comprising; spectral characteristics; separation device; sensitive optical; lipid-bilayer materials; layer material; spectral characteristic; delivery systems; lipid membranes; method allow; processing conditions; lipid-bilayer material; layer materials; /424/264/428/

Citation Formats

Sasaki, Darryl Y., Loy, Douglas A., and Yamanaka, Stacey A. Immobilized lipid-bilayer materials. United States: N. p., 2000. Web.
Sasaki, Darryl Y., Loy, Douglas A., & Yamanaka, Stacey A. Immobilized lipid-bilayer materials. United States.
Sasaki, Darryl Y., Loy, Douglas A., and Yamanaka, Stacey A. Sat . "Immobilized lipid-bilayer materials". United States. https://www.osti.gov/servlets/purl/872946.
@article{osti_872946,
title = {Immobilized lipid-bilayer materials},
author = {Sasaki, Darryl Y. and Loy, Douglas A. and Yamanaka, Stacey A.},
abstractNote = {A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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