Title: Immobilized lipid-bilayer materials

Abstract

A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.

Inventors:

Sasaki, Darryl Y ^[1]; Loy, Douglas A ^[1]; Yamanaka, Stacey A ^[2]

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+ Show Inventor Affiliations

1. Albuquerque, NM
2. Dallas, TX

Issue Date:

Sat Jan 01 00:00:00 EST 2000

Research Org.:

Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

OSTI Identifier:

872946

Patent Number(s):

6048546

Assignee:

Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K9/1272 - {with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
A61K9/5015 - {Organic compounds, e.g. fats, sugars}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T428/2984 - Microcapsule with fluid core [includes liposome]

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DOE Contract Number:  

AC04-94AL85000

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

immobilized; lipid-bilayer; materials; method; preparing; encapsulated; silica; matrix; comprising; sol; mixing; material; allowing; mixture; form; mild; processing; conditions; allow; quantitative; entrapment; pre-formed; modification; spectral; characteristics; allows; immobilization; lipid; membranes; surfaces; perform; sensitive; optical; sensors; detection; analytes; heavy; metal; drug; delivery; systems; separation; devices; comprising preparing; silica sol; optical sensors; heavy metal; drug delivery; optical sensor; method allows; separation devices; matrix comprising; spectral characteristics; separation device; sensitive optical; lipid-bilayer materials; layer material; spectral characteristic; delivery systems; lipid membranes; method allow; processing conditions; lipid-bilayer material; layer materials; /424/264/428/